Dyslipoproteinaemia after Ileal Resection in Crohn’s Disease

Johansson, C.; Rössner, Stephan; Walldius, Göran; Kollberg, B.

doi:10.1159/000198327

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…The previously described alterations of the plasma lipoprotein composition after ileal resection in Crohn's disease [1] were con firmed in this study. The decreased total plasma cholesterol is mainly due to reduced LDL cholesterol levels.…”

Section: Discussionsupporting

confidence: 56%

“…Patients with Crohn's disease operated with ileal resection have low levels of choles terol in their circulating low-density lipopro teins (LDL) [1], Furthermore, significant negative correlations have been found be tween the length of the resection and the cholesterol concentrations in LDL and highdensity lipoproteins (HDL) fractions [1]. The low LDL cholesterol concentration mainly results from loss of biliary salts in the intestine which stimulates further hepatic catabolism of endogenously stored and syn thesized cholesterol [2,3].…”

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confidence: 99%

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Fatty Acid Composition in Serum Lipids and Adipose Tissue in Patients with Morbus Crohn after Heal Resection

Johansson

Walldius²,

Rössner³

1987

Digestion

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In 36 patients with Crohn’s disease who had been operated with ileal resection but were in a stable clinical condition, the fatty acid composition in the circulation and in adipose tissue was correlated to resection length. Fatty acid composition was also compared to data from a group of randomly selected healthy men and women of similar age. In plasma Crohn patients had reduced circulating levels of unsaturated fatty acids. On the other hand, increased proportions of these fatty acids were found in adipose tissue. It is unlikely that in this group of patients these data are unspecifíc reflections of disease activity. A more reasonable explanation seems to be an increased demand for precursors of local prostaglandin synthesis in the remainig bowel.

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Section: Discussionsupporting

confidence: 56%

mentioning

confidence: 99%

Fatty Acid Composition in Serum Lipids and Adipose Tissue in Patients with Morbus Crohn after Heal Resection

Johansson

Walldius²,

Rössner³

1987

Digestion

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Plasma Fatty Acid Composition in Patients with Ileal Dysfunction

Färkkilä

Tilvis

Miettinen

1987

Scandinavian Journal of Gastroenterology

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Chemical signs of essential fatty acid deficiency (EFD) were studied in 31 patients who has undergone an ileal resection on an average 7 years earlier by determining fatty acid composition in serum lipids. The subjects were divided into two groups in accordance with the presence (greater than 7 g/day) or absence (less than 7 g/day) of fat malabsorption. The two groups were matched for age, nutritional status, and essential fatty acid intake, but the patients with steatorrhea had higher levels of fecal bile acids and serum triglycerides and lower levels of serum cholesterol than those without steatorrhea. The contents of linoleic acid (LA; 18:2,n-6), the sum of n-6 polyunsaturated fatty acids, and eicosapentaenoic acid levels were lower, whereas those of the C 14-18 saturated and monoenoic fatty acids and eicosatrienoic fatty acid (ETA; 20:3,n-9), a characteristic fatty acid of EFD, were higher in the serum lipids of the patients with fat malabsorption. The LA of cholesterol esters, the ETA of phospholipids, and the ETA to arachidonic acid ratio of phospholipids were closely correlated with the amount of fecal fat, less significantly with the composition of dietary fat or the length of excluded intestine, and not at all with relative body weight or the amount of fecal bile acids. Changes in fatty acid patterns, considered characteristic of EFD, were found for almost a third of the patients with fat malabsorption; yet no clinical evidence of EFD was documented. Thus, the results demonstrate that chemical signs of EFD are common in patients with fat malabsorption after gut resections despite the good nutritional status. The findings suggest that, for preventive purposes, patients with gut resections should increase their dietary intake of polyunsaturated fatty acids in proportion to the amount of fecal fat.

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Association of serum lipids with inflammatory bowel disease: a systematic review and meta-analysis

Chen,

Li,

et al. 2023

Front. Med.

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BackgroundSerum lipid levels seem to be abnormal in Inflammatory bowel disease (IBD). However, the specific manifestation of abnormal serum lipid levels in IBD are heterogeneous among studies and have not been sufficiently determined yet.MethodsPubMed, EMBASE, and Cochrane Library databases were searched. Serum lipid levels were compared between IBD patients and Health individuals, Crohn’s (CD) and ulcerative colitis (UC), active and inactive, mild and non-mild patients, respectively. Meta-analyses were performed by using a random-effect model. Weight mean difference (WMD) with 95% confidence intervals (CIs) were calculated.ResultsOverall, 53 studies were included. Compared with healthy controls, IBD patients had significantly lower TC (WMD = −0.506, 95%CI = −0.674 to −0.338, p < 0.001), HDL-c (WMD = −0.122, 95%CI = −0.205 to −0.039, p = 0.004), and LDL-c (WMD = −0.371, 95%CI = −0.547 to −0.194, p < 0.001) levels. CD groups had a significantly lower TC (WMD = −0.349, 95%CI = −0.528 to −0.170, p < 0.0001) level as compared to UC groups. Active IBD and non-mild UC groups had significantly lower TC (WMD = −0.454, 95%CI = −0.722 to −0.187, p = 0.001) (WMD =0.462, 95%CI = 0.176 to 0.748, p = 0.002) and LDL-c (WMD = −0.225, 95%CI = −0.445 to −0.005, p = 0.045) (WMD =0.346, 95%CI = 0.084–0.609, p = 0.010) levels as compared to inactive IBD and mild UC groups, respectively.ConclusionThe overall level of serum lipids in IBD patients is lower than that of healthy individuals and is negatively associated with disease severity.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42022383885.

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Dyslipoproteinaemia after Ileal Resection in Crohn’s Disease

Cited by 3 publications

References 12 publications

Fatty Acid Composition in Serum Lipids and Adipose Tissue in Patients with Morbus Crohn after Heal Resection

Fatty Acid Composition in Serum Lipids and Adipose Tissue in Patients with Morbus Crohn after Heal Resection

Plasma Fatty Acid Composition in Patients with Ileal Dysfunction

Association of serum lipids with inflammatory bowel disease: a systematic review and meta-analysis

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