Dysregulated inflammation may predispose patients with serious mental illnesses to severe COVID‑19 (Review)

Nadalin, Sergej; Jakovac, Hrvoje; Peitl, Vjekoslav; Karlović, Dalibor; Buretić‐Tomljanović, Alena

doi:10.3892/mmr.2021.12250

Cited by 7 publications

(7 citation statements)

References 142 publications

(183 reference statements)

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“…Dietary methyl-donors taking part in one-carbon metabolism affect several metabolic processes as well as age and metabolic state-specific DNA methylation, which is necessary for the healthy regulation of gene transcription and thus healthy metabolic regulation [ 1 , 3 , 22 , 32 , 33 , 34 ]. Reports and studies during on COVID-19 showed that both the very low and too high concentration of vitamins B and D, micronutrients and minerals make the human body vulnerable to chronic diseases or infections [ 35 , 36 , 37 , 38 ]. Indeed, we also found that the dietary intake of methyl-donors such as methionine, B6, B9 and the summative amounts of methyl-donor intakes (SUM MD) in terms of RDA levels significantly increased the overall survival of breast and colorectal cancer patients.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Dietary Methyl-Donor Intake and Other Lifestyle Factors on Cancer Patients in Hungary

Kiss

Hajdu²,

Forika³

et al. 2022

Cancers

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Background: Nutrition is essential to life and can have an indisputable influence on health and prevention of disease development including cancer. Methyl-donors are macronutrients that are important in achieving a healthy balance of metabolic processes. Their deficiency can lead to several symptoms and diseases—even to severe SARS-CoV-2 infection. We aimed to explore the potential protective effect of methyl-donor intake in breast, colorectal and pancreatic cancer by patient follow up. Methods: A food frequency questionnaire and a diet diary were used to evaluate methyl-donor intake and blood samples were taken to evaluate Il-6 and IL-8 cytokine levels as well as MTHFR (C677T) polymorphism in breast, colorectal and pancreatic cancer patients. Results: We found that levels around the recommended daily intake of B6 and B9 were effective in supporting the overall survival of breast and colorectal, and a relatively higher level of pancreatic adenocarcinoma, patients. The total intake of methyl-donors significantly and negatively correlated with smoking in pancreatic cancer, while folate as well as betaine intake significantly and positively correlated with IL-8 in colorectal cancer patients. Conclusions: Our results suggest that the appropriate intake of methyl-donor can be an adjunct of conventional oncotherapy to improve quality of life. Whether methyl-donor intake supports cancer prevention and patient survival needs further confirmation in large patient cohorts.

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Section: Discussionmentioning

confidence: 99%

The Effect of Dietary Methyl-Donor Intake and Other Lifestyle Factors on Cancer Patients in Hungary

Kiss

Hajdu²,

Forika³

et al. 2022

Cancers

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“…Initial investigations were primarily focused on the molecular pathology of SARS-CoV-2 infection; however, later investigations demonstrated the involvement of nutritional deficiencies and neuropsychiatric illnesses in worsening the COVID-19 pathological manifestations. Moreover, the impact of social measures to prevent spread of SARS-CoV-2 infection drive the psychological derailment; and is also suggested to be considered for effective management of the COVID-19 pandemic (Girdhar et al, 2020;Soni et al, 2020b,d;Kumar and Nayar, 2021;Mehta et al, 2021;Nadalin et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…The investigators hypothesized a link between ingesting foods with high anti-ACE activity and having a low COVID-19 mortality rate (Nadalin et al, 2021). Few of the countries with low mortality rates such as Bulgaria, Greece, and Turkey record for consumption of fermented milk, which is known to be an organic ACE inhibitor.…”

Section: Role Of Altered Immune Responsementioning

confidence: 99%

Interplay of Nutrition and Psychoneuroendocrineimmune Modulation: Relevance for COVID-19 in BRICS Nations

Mehta

Ratre

Sharma³

et al. 2021

Front. Microbiol.

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The consequences of COVID-19 are not limited to physical health deterioration; the impact on neuropsychological well-being is also substantially reported. The inter-regulation of physical health and psychological well-being through the psychoneuroendocrineimmune (PNEI) axis has enduring consequences in susceptibility, treatment outcome as well as recuperation. The pandemic effects are upsetting the lifestyle, social interaction, and financial security; and also pose a threat through perceived fear. These consequences of COVID-19 also influence the PNEI system and wreck the prognosis. The nutritional status of individuals is also reported to have a determinative role in COVID-19 severity and convalescence. In addition to energetic demand, diet also provides precursor substances [amino acids (AAs), vitamins, etc.] for regulators of the PNEI axis such as neurotransmitters (NTs) and immunomodulators. Moreover, exaggerated immune response and recovery phase of COVID-19 demand additional nutrient intake; widening the gap of pre-existing undernourishment. Mushrooms, fresh fruits and vegetables, herbs and spices, and legumes are few of such readily available food ingredients which are rich in protein and also have medicinal benefits. BRICS nations have their influences on global development and are highly impacted by a large number of confirmed COVID-19 cases and deaths. The adequacy and access to healthcare are also low in BRICS nations as compared to the rest of the world. Attempt to combat the COVID-19 pandemic are praiseworthy in BRICS nations. However, large population sizes, high prevalence of undernourishment (PoU), and high incidence of mental health ailments in BRICS nations provide a suitable landscape for jeopardy of COVID-19. Therefore, appraising the interplay of nutrition and PNEI modulation especially in BRICS countries will provide better understanding; and will aid in combat COVID-19. It can be suggested that the monitoring will assist in designing adjunctive interventions through medical nutrition therapy and psychopsychiatric management.

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“…Given that psychiatric conditions have been found to be risk factors for severe COVID-19 (19) and that severe COVID-19 is associated with higher rates of long COVID (3,9), it is possible that any increased risk of long COVID associated with preexisting psychiatric conditions is due to increased severity of infection. A secondary analysis was conducted to control for severity of infection by controlling for hospitalization acutely after COVID-19 infection to examine only mild COVID-19 cases (queries and analysis found in Supplementary Materials, http://links.lww.com/ PSYMED/A995).…”

Section: Methodsmentioning

confidence: 99%

Preexisting Psychiatric Conditions as Risk Factors for Diagnosed Long COVID-19 Syndrome Within Aggregated Electronic Health Record Data

Bobak,

Dorney,

Kovacevich

et al. 2024

Psychosom Med

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Objective To investigate the frequency of long COVID diagnosis among patients infected with SARS-CoV-2 with pre-existing psychiatric conditions versus those without pre-existing psychiatric conditions. Methods The TriNetX Analytics platform, an aggregated Electronic Health Record (EHR) research network containing the de-identified EHR data of over 90 million patients, was queried for patients who were diagnosed with COVID-19 infection based on International Classifications of Disease, Tenth Revision (ICD-10) codes. Patients were stratified based on their pre-existing psychiatric conditions and new diagnoses of long COVID were recorded and reported as the primary outcome. Results Among 1,180,948 patients previously diagnosed with COVID-19, 17,990 (1.52%) patients were diagnosed with long COVID based on the newly implemented ICD-10 code “U09: Post COVID-19 condition”. After propensity score matching, patients with any pre-existing psychiatric diagnosis had a 1.52 (95% CI: 1.47,1.58) times greater prevalence of diagnosed long COVID within 180 days of infection than patients without pre-existing psychiatric diagnoses. Patients with diagnosed anxiety disorders (RR: 1.64, 95% CI: 1.57,1.71), mood disorders (RR:1.65, 95% CI: 1.57,1.72), bipolar disorder (RR:1.37, 95% CI: 1.21,1.54), major depressive disorder (RR:1.69, 95% CI: 1.56,1.83), psychotic disorders (RR:1.23, 95%: 1.06,1.44) and substance use disorders (RR:1.28, 95% CI: 1.22,1.36) had higher risks for long COVID diagnoses when compared with patients without pre-existing psychiatric illness at the time of diagnosis. Conclusion Multiple pre-existing psychiatric diagnoses are associated with an increased risk of being diagnosed with long COVID after COVID-19 infection.

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Dysregulated inflammation may predispose patients with serious mental illnesses to severe COVID‑19 (Review)

Cited by 7 publications

References 142 publications

The Effect of Dietary Methyl-Donor Intake and Other Lifestyle Factors on Cancer Patients in Hungary

The Effect of Dietary Methyl-Donor Intake and Other Lifestyle Factors on Cancer Patients in Hungary

Interplay of Nutrition and Psychoneuroendocrineimmune Modulation: Relevance for COVID-19 in BRICS Nations

Preexisting Psychiatric Conditions as Risk Factors for Diagnosed Long COVID-19 Syndrome Within Aggregated Electronic Health Record Data

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