E-Cadherin and Syndecan-1 Expression in Patients With Advanced Non-small Cell Lung Cancer Treated With Chemoradiotherapy

Gkogkou, Pinelopi; Peponi, Evangelia; Ntaskagiannis, Dimitrios; Murray, Samuel; Demou, A; Sainis, Ioannis; Ioakeim, Elli; Briasoulis, Evangelos; Tsekeris, P.

doi:10.21873/invivo.11795

Cited by 9 publications

(6 citation statements)

References 29 publications

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“…Again, consistent with TCGA data, high protein staining of E-cad in kidney renal papillary cell carcinoma was associated with worse prognosis, and no association was detected for kidney renal clear cell carcinoma (96). Recent analysis of E-cad in the cohort of NSCLC with 66% cases representing squamous cell carcinoma identifies E-cad as a positive prognostic factor consistent with TCGA data (97).…”

Section: Expression Of Molecules Involved In the Ctc Cluster Formatio...supporting

confidence: 76%

Molecules promoting circulating clusters of cancer cells suggest novel therapeutic targets for treatment of metastatic cancers

Rozenberg

Buzdin²,

Mohammad³

et al. 2023

Front. Immunol.

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Treatment of metastatic disease remains among the most challenging tasks in oncology. One of the early events that predicts a poor prognosis and precedes the development of metastasis is the occurrence of clusters of cancer cells in the blood flow. Moreover, the presence of heterogeneous clusters of cancerous and noncancerous cells in the circulation is even more dangerous. Review of pathological mechanisms and biological molecules directly involved in the formation and pathogenesis of the heterotypic circulating tumor cell (CTC) clusters revealed their common properties, which include increased adhesiveness, combined epithelial-mesenchymal phenotype, CTC-white blood cell interaction, and polyploidy. Several molecules involved in the heterotypic CTC interactions and their metastatic properties, including IL6R, CXCR4 and EPCAM, are targets of approved or experimental anticancer drugs. Accordingly, analysis of patient survival data from the published literature and public datasets revealed that the expression of several molecules affecting the formation of CTC clusters predicts patient survival in multiple cancer types. Thus, targeting of molecules involved in CTC heterotypic interactions might be a valuable strategy for the treatment of metastatic cancers.

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Section: Expression Of Molecules Involved In the Ctc Cluster Formatio...supporting

confidence: 76%

Molecules promoting circulating clusters of cancer cells suggest novel therapeutic targets for treatment of metastatic cancers

Rozenberg

Buzdin²,

Mohammad³

et al. 2023

Front. Immunol.

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“…ICAM‐1 might be a target molecule for NIR‐PIT against other cancers that express it. Previous studies showed that ICAM‐1 expression was detected in 41%, 50%, and 44% of non‐small‐cell lung cancers, 33 gastric cancers, 34 and colorectal cancers 35 . Further research is necessary to evaluate the therapeutic efficacy of ICAM‐1‐targeted NIR‐PIT in mouse models of these cancers.…”

Section: Discussionmentioning

confidence: 99%

Intercellular adhesion molecule‐1‐targeted near‐infrared photoimmunotherapy of triple‐negative breast cancer

et al. 2022

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Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and conventional chemotherapy and molecular‐targeted therapies show limited efficacy. Near‐infrared photoimmunotherapy (NIR‐PIT) is a new anticancer treatment that selectively damages the cell membrane of cancer cells based on NIR light‐induced photochemical reactions of the antibody (Ab)‐photoabsorber (IRDye700Dx) conjugate and the cell membrane. TNBC is known to express several adhesion molecules on the cell surface providing a potential new target for therapy. Here, we investigated the therapeutic efficacy of intercellular adhesion molecule‐1 (ICAM‐1)‐targeted NIR‐PIT using xenograft mouse models subcutaneously inoculated with two human ICAM‐1‐expressing TNBC cell lines, MDAMB468‐luc and MDAMB231 cells. In vitro ICAM‐1‐targeted NIR‐PIT damaged both cell types in a NIR light dose‐dependent manner. In vivo ICAM‐1‐targeted NIR‐PIT in both models showed early histological signs of cancer cell damage, such as cytoplasmic vacuolation. Even among the cancer cells that appeared to be morphologically intact within 2 h post treatment, abnormal distribution of the actin cytoskeleton and a significant decrease in Ki‐67 positivity were observed, indicating widespread cellular injury reflected in cytoplasmic degeneration. Such damage to cancer cells by NIR‐PIT significantly inhibited subsequent tumor growth and improved survival. This study suggests that ICAM‐1‐targeted NIR‐PIT could have potential clinical application in the treatment of TNBC.

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“…The loss of expression of E-cadherin in the spindle and giant cell epithelial component in resection materials may explain the invasive potential and increase of their metastases of these Ts. TKI (Tyrosine Kinase Inhibitors) is frequently used in the treatment of NSCLC and EMT is believed to play an important role in resistance to these drugs (20,21). Some studies have shown that EMT is involved not only in determining the prognosis of patients with NSCLC, but also in response to specific treatments such as anti-EGFR treatments used for this type of T (22).…”

Section: Discussionmentioning

confidence: 99%

The Importance of Low E-cadherin Expression for Epithelial Mesenchymal Transition (EMT) in Pulmonary Pleomorphic Carcinoma

Ünver¹,

Büyükpınarbaşılı²

2021

hamidiyemedj

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Background: Epithelial-mesenchymal transition is an important step in the invasion and metastasis of cancer cells in various cancer types. The aim of this study is to evaluate immunohistochemical staining with E-cadherin in patients with pleomorphic carcinoma (PC), which is a group of advanced lung tumors, to decide the correlation between clinicopathological parameters and to determine the prognostic significance of the results. Materials and Methods:Materials and data of 56 cases diagnosed with PC between January 2011 and December 2018 were evaluated. Expressions of E-cadherin applied to tumor sections of resection materials were evaluated. Immunohistochemically, data were collected under two groups as low and high according to E-cadherin staining results. The results obtained were compared with clinicopathological findings and prognostic factors.Results: Forty-five of the fifty-six cases were male (80.36%) and 11 were female (19.64%), their age ranged from 44 to 83 years and the average age was 64.12 years. When expressions of E-cadherin were evaluated, loss of expression of E-cadherin (low expression) was observed in 47 (83.9%) cases. When the disease-free survival time was examined, it was found that the mean time (12 months) in 35 cases was below. No statistically significant correlation was found between the immunohistochemically E-cadherin expressions and other clinicopathological parameters. Our study showed that low E-cadherin expression or loss of E-cadherin expression in spindle and/or giant cell areas has a poor prognostic factor on disease-free survival (p=0.001).Conclusion: E-cadherin loss has been observed in cases of PC, especially in spindle and/or giant cell areas, and has been associated with shorter disease-free survival. Expression loss of E-cadherin was accepted as a poor prognostic factor. Expression of E-cadherin can be used to evaluate the prognostic potential in PCs with poorly progressive groups.

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E-Cadherin and Syndecan-1 Expression in Patients With Advanced Non-small Cell Lung Cancer Treated With Chemoradiotherapy

Cited by 9 publications

References 29 publications

Molecules promoting circulating clusters of cancer cells suggest novel therapeutic targets for treatment of metastatic cancers

Molecules promoting circulating clusters of cancer cells suggest novel therapeutic targets for treatment of metastatic cancers

Intercellular adhesion molecule‐1‐targeted near‐infrared photoimmunotherapy of triple‐negative breast cancer

The Importance of Low E-cadherin Expression for Epithelial Mesenchymal Transition (EMT) in Pulmonary Pleomorphic Carcinoma

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