E-cadherin (CDH1) gene promoter polymorphism and the risk of colorectal cancer

Wang, Yadong; Yang, Haiyan; Li, Li; Li, Ang; Zhang, Congke; Xia, Xiangqun

doi:10.1007/s00384-011-1320-7

Cited by 8 publications

(7 citation statements)

References 38 publications

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“…It has been shown that the −160A allele decreases the transcription efficiency of the CDH1 gene [15, 16]. Meta-analyses suggest that rs16260 may be associated with the risk of colorectal cancer (CRC) in Western populations and sporadic gastric carcinoma among Caucasians, but not among Asians [11, 17]. Interestingly, in the study of Zhan et al [18], genotypes of the CDH1 rs16260 variant contributed to the risk of diffuse gastric cancer in ethnic Han Chinese.…”

Section: Introductionmentioning

confidence: 99%

Nucleotide variants of the cancer predisposing gene CDH1 and the risk of non-syndromic cleft lip with or without cleft palate

et al. 2014

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The CDH1 gene plays an important role during carcinogenesis and craniofacial morphogenesis. Germline mutations in this gene have been described in families presenting syndromic diffuse gastric cancer and orofacial clefts. The aim of this study was to evaluate the association between nucleotide variants of CDH1 and the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P). Six single nucleotide polymorphisms (SNPs) of the CDH1 gene (rs16260, rs9929218, rs7186053, rs4783573, rs16958383, and rs1801552) were genotyped using the TaqMan SNP genotyping assays in 250 patients with NSCL/P and 540 controls from the Polish population. Comparison between patient and control groups showed that the CDH1 rs1801552 variant, under the assumption of recessive model, was associated with a two-fold decrease in the risk of NSCL/P (ORTT vs CT + CC = 0.481, 95 % CI 0.281–0.824, p = 0.007). This association remained statistically significant even after the multiple testing correction. No significant associations with NSCL/P risk were found for the other five tested SNPs. We found a strong association between the cancer predisposing gene CDH1 and the risk of NSCL/P in the Polish population. This result, together with previous observations of co-occurrence of orofacial clefts and a variety of cancer types, suggests the need for replication studies testing rs1801552 in NSCL/P cohorts with a known cancer history.

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Section: Introductionmentioning

confidence: 99%

Nucleotide variants of the cancer predisposing gene CDH1 and the risk of non-syndromic cleft lip with or without cleft palate

et al. 2014

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“…These results indicated that the -160 AA genotype increased breast cancer risk, which was consistent with results on other cancer types, such as prostate, urothelial, and bladder cancers [ 27 – 29 ]. However, the results were inconsistent with results on colorectal cancer (CRC) [ 12 , 30 ], which showed that CDH1 -160C/A polymorphisms could reduce CRC risk. These results revealed that the CDH1 -160C/A polymorphism might have different effects on distinct cancers, and this discrepancy may result from different carcinogenesis mechanisms, such as genetic background, environment exposure, dietary habit, race, or family history.…”

Section: Discussionmentioning

confidence: 91%

The CDH1 -160C/A polymorphism is associated with breast cancer: evidence from a meta-analysis

Liu

et al. 2016

World J Surg Onc

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BackgroundNumerous epidemiological studies have evaluated the association between the CDH1 -160C/A polymorphism and the risk of breast cancers. However, these studies have yielded conflicting results. To derive a more precise estimation of this association, this meta-analysis was conducted.MethodsA comprehensive search using the keywords “CDH1,” “E-Cadherin,” “polymorphism,” “SNP,” and “variant” combined with “breast,” “cancer,” “tumor,” or “carcinomas” was conducted. Pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were appropriately calculated using a fixed effect or random effect model. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 checklist was used for this meta-analysis.ResultsFour publications including five studies were identified. It was found that the CDH1 -160C/A polymorphism was significantly associated with breast cancer risk in the dominant model (CA + AA vs. CC: OR = 1.207, 95 % CI = 1.031–1.412, P = 0.019).ConclusionsOur meta-analysis demonstrated that the -160C/A polymorphism in the CDH1 gene might contribute to breast cancer susceptibility. Further investigations using a much larger sample including different ethnicities are still needed to verify this association.Electronic supplementary materialThe online version of this article (doi:10.1186/s12957-016-0927-0) contains supplementary material, which is available to authorized users.

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“…6 Recently, three previous meta-analyses evaluated the association between the CDH1 polymorphism and the risk of CRC based on nine, eight and eight studies, respectively. [36][37][38] Howerer, the combined results were also inconclusive. Wang et al 36 reported a protective effect of the CDH1-160 CA + AA polymorphisms for CRC in population-based control in stratified analysis, whereas a meta-analysis conducted by Geng et al 37 found that the CDH1-C160A polymorphism provides a possible protection against CRC, which is especially evident in Caucasian and hospital populations.…”

Section: Discussionmentioning

confidence: 96%

E‐cadherin (CDH1) gene –160C/A polymorphism and the risk of colorectal cancer: A meta‐analysis involving 17,291 subjects

Wang

2021

The Journal of Gene Medicine

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Background: The E-cadherin (CDH1) polymorphism has been implicated in the susceptibility to colorectal cancer (CRC). However, the results remain inconclusive.The present meta-analysis aimed to investigate the association between the CDH1-160C/A polymorphism and CRC risk.Methods: Relevant studies were retrieved by searching PubMed, Web of Science, Google Scholar, the Cochrane Library, Embase, CNKI and Wanfang databases up to 11 March 2021. Pooled odds ratio and 95% confidence interval were calculated using either the fixed-or random-effects model. Quality evaluation was carried out using Newcastle-Ottawa Scale (NOS). A trial sequential analysis (TSA) was conducted to reduce the risk of type I error.Results: In total, 16 studies from 14 articles with 8699 patients and 8592 controls were included. In general, all studies were of high quality (NOS score higher than 6).Overall, no significant associations between the CDH1 -160C/A polymorphism and CRC risk were detected. In subgroup analysis by ethnicity, source of control, genotyping method and location, significant associations were found between the CDH1-160C/A polymorphism and the risk of CRC in the Caucasians and the hospital-based subgroup. Furthermore, 10 studies with 8019 subjects reported the association between the polymorphism and clinical characteristics in CRC patients, and we found that the CDH1-160C/A polymorphism might show a protective role in the distal CRC subgroup. By TSA, the findings in the present study were based on sufficient evidence in Caucasians, but not in Asians.Conclusions: This meta-analysis suggests that the CDH1-160C/A polymorphism may be an important protective factor for CRC in Caucasians and a hospital-based subgroup. Moreover, the polymorphism show a protective role in the distal CRC group. However, large and well-designed studies are warranted to validate our findings, especially for Asians. K E Y W O R D S CDH1, colorectal cancer, meta-analysis, polymorphism 1 | INTRODUCTION Colorectal cancer (CRC) is one of the most common gastrointestinal tumors worldwide. CRC ranks third in terms of incidence and second in terms of mortality based on the GLOBOCAN 2018. 1 The exact etiology and pathogenesis of CRC remain unclear. Epidemiological studies have demonstrated that some risk factors and interactions between genetic and environmental factors may play important roles

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E-cadherin (CDH1) gene promoter polymorphism and the risk of colorectal cancer

Cited by 8 publications

References 38 publications

Nucleotide variants of the cancer predisposing gene CDH1 and the risk of non-syndromic cleft lip with or without cleft palate

Nucleotide variants of the cancer predisposing gene CDH1 and the risk of non-syndromic cleft lip with or without cleft palate

The CDH1 -160C/A polymorphism is associated with breast cancer: evidence from a meta-analysis

E‐cadherin (CDH1) gene –160C/A polymorphism and the risk of colorectal cancer: A meta‐analysis involving 17,291 subjects

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