2021
DOI: 10.1016/j.cdtm.2021.02.003
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Early chronic obstructive pulmonary disease: A new perspective

Abstract: Chronic obstructive pulmonary disease (COPD) is a respiratory disease with a high incidence, mortality, and disability rate. Because there are few symptoms in the early stages of COPD, diagnosis and treatment are seriously insufficient. It is necessary to find effective clues for early COPD diagnosis and provide appropriate interventions. Several studies suggest that small airway disease is the earliest stage of COPD because it is correlated with subsequent development of airflow obstruction. However, there ar… Show more

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Cited by 9 publications
(9 citation statements)
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References 96 publications
(194 reference statements)
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“…Emphysema progresses gradually with alveolar destruction causing the tiny air sacs to rupture, creating one large air pocket instead of many small ones (Lu et al, 2021). This causes a reduction in lung surface area and loss of elasticity.…”
Section: Copd Chronic Bronchitis and Emphysemamentioning
confidence: 99%
See 1 more Smart Citation
“…Emphysema progresses gradually with alveolar destruction causing the tiny air sacs to rupture, creating one large air pocket instead of many small ones (Lu et al, 2021). This causes a reduction in lung surface area and loss of elasticity.…”
Section: Copd Chronic Bronchitis and Emphysemamentioning
confidence: 99%
“…This causes a reduction in lung surface area and loss of elasticity. Air gets trapped in the damaged alveoli, preventing the movement of oxygen into the bloodstream and the removal of carbon dioxide (Lu et al, 2021). The lungs gradually overfill, making breathing difficult.…”
Section: Copd Chronic Bronchitis and Emphysemamentioning
confidence: 99%
“…Por lo tanto, consideramos que no solo es un problema de madurez y crecimiento pulmonar, si no que se trata de una enfermedad pulmonar crónica, que afectará al prematuro cuando esté expuesto a situaciones de mayor requerimiento de su reserva, como una infección viral, sobre todo durante el primer año de la vida, o durante el ejercicio en la edad escolar (23). Incluso estos niños tienen mayor posibilidad de presentar cuadros respiratorios semejantes al asma, sin buena respuesta a corticoides inhalados y mayor probabilidad de desarrollar EPOC en su etapa adulta (3,24).…”
Section: Espectro De La Fisiopatología Y Presentación Clínica De La Dbpunclassified
“… 5 FEV 1 and forced vital capacity (FVC) decline with age, and FEV 1 declines faster than FVC. 12 Since the international guidelines failed to correct for age, the elderly are over-diagnosed and the younger population is underdiagnosed. 13 Nonetheless, there are no clear diagnostic criteria for early COPD.…”
Section: The Definition Of Early Copdmentioning
confidence: 99%