Early Effects of Gamma Radiation on the Developing Rat Cerebellum: Induction of cell pyknosis

Cerda, Humberto

doi:10.3109/02841868309134356

Cited by 6 publications

(1 citation statement)

References 13 publications

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“…Neuroblasts and stem cells present in mouse brain foetuses are highly radiosensitive and are killed due to exposure. Cell death induction by low HTO doses in the developing cerebellar cortex reported in the present study confirmed earlier findings of Cerda [12]. Apart from it, cell necrosis and pycnosis have also been observed in the present study.…”

Section: Discussionsupporting

confidence: 82%

Tritium in the environment and its impact assessment against the existing radiation protection framework revisited

Jain¹,

Bhatia

2011

Radioprotection

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Abstract. With the development of nuclear power programme, an additional consideration outside the existing radiation protection framework appeared: the need to assess not only the level of exposure, but also to take into consideration the accidents which could release large inventories of radioactivity. With the expansion of nuclear commitments, the inventories of Tritium are bound to increase. The possible use of tritium as the fuel for fusion reactors in the near future may result in an additional source of tritium. Swiss albino mice of 1, 2, 3, 4 & 6 weeks of age were injected with tritiated water (HTO) at the dose 111 kBq/gram body weight and the animals from each age group autopsied on 1, 7 and 30 days post-injection. The mouse show radiovulnerability with a capability to repair and recover from the rendered damage during the first half (1 week to 3 week) of postnatal development, whereas during the second half (4 week to 6 week of age) a tendency towards radioresistance is achieved. The presentation is an attempt to revisit the behaviour of tritium with its possible implications on the environment in accordance with the presently projected radiation protection framework.

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Section: Discussionsupporting

confidence: 82%

Tritium in the environment and its impact assessment against the existing radiation protection framework revisited

Jain¹,

Bhatia

2011

Radioprotection

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Prenatal exposure to gamma/neutron irradiation: Sensorimotor alterations and paradoxical effects on learning

1991

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The effects of prenatal exposure on gamma/neutron radiations (0.5 Gy at about the 18th day of fetal life) were studied in a hybrid strain of mice (DBA/Cne males x C57BL/Cne females). During ontogeny, measurements of sensorimotor reflexes revealed in prenatally irradiated mice 1) a delay in sensorial development, 2) deficits in tests involving body motor control, and 3) a reduction of both motility and locomotor activity scores. In adulthood, the behaviour of prenatally irradiated and control mice was examined in the open field test and in reactivity to novelty. Moreover, their learning performance was compared in several situations. The results show that, in the open field test, only rearings were more frequent in irradiated mice. In the presence of a novel object, significant sex x treatment interactions were observed since ambulation and leaning against the novel object increased in irradiated females but decreased in irradiated males. Finally, when submitted to different learning tasks, irradiated mice were impaired in the radial maze, but paradoxically exhibited higher avoidance scores than control mice, possibly because of their low pain thresholds. Taken together, these observations indicate that late prenatal gamma/neutron irradiation induces long lasting alterations at the sensorimotor level which, in turn, can influence learning abilities of adult mice.

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Kinetics of Radiation-induced Apoptosis in the Cerebellum of 14-day-old Rats after Acute or during Continuous Exposure

Fritsch

Naour

Denis

et al. 1994

International Journal of Radiation Biology

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We have studied, by histological methods, cytological progression, frequency and distribution of apoptosis in the external granular layer of the cerebellum after whole-body irradiation of 14-day-old rats by gamma-rays from 60 Co. After acute exposure to 0.25, 0.5, 1.5 and 3 Gy (18 cGy/min), the duration of the apoptotic process gradually increased with dose from 6-9 h after 0.25 Gy, to > 24 h after 3 Gy. Up to 1 Gy, maximal frequency was found 6 h after exposures, and at this postirradiation time a linear increase in apoptosis with dose was observed. No effect of dose-rate on apoptosis induction could be demonstrated 6 h after delivering 1 Gy at dose-rates from 2.2 to 18 cGy/min. Continuous irradiation at 1.8 cGy/h induced a gradual increase of apoptosis that remained at a plateau value of about 3% from 15 to 29 h (controls 0.12%, SD = 0.07) and then gradually decreased to 1% at 53 h. At this time the mitotic index was similar to that measured in controls. Apoptosis occurring 3 h after acute irradiation, confined to proliferative cells, was only observed for doses of 1.5 and 3 Gy.

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Early Effects of Gamma Radiation on the Developing Rat Cerebellum: Induction of cell pyknosis

Cited by 6 publications

References 13 publications

Tritium in the environment and its impact assessment against the existing radiation protection framework revisited

Tritium in the environment and its impact assessment against the existing radiation protection framework revisited

Prenatal exposure to gamma/neutron irradiation: Sensorimotor alterations and paradoxical effects on learning

Kinetics of Radiation-induced Apoptosis in the Cerebellum of 14-day-old Rats after Acute or during Continuous Exposure

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