2006
DOI: 10.1378/chest.130.5.1579
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Early Goal-Directed Therapy in Severe Sepsis and Septic Shock Revisited

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Cited by 266 publications
(195 citation statements)
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References 112 publications
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“…(13,14,(25)(26)(27)(28) There is evidence that therapeutic intervention with hemodynamic resuscitation and antibiotic therapy are associated to lower mortality rates. (7)(8)(9)(10)(11)(12)15) As such, agile and adequate treatment is the "mainstay" for a successful approach to severe sepsis. (18)(19)(20) Goal directed early therapy proposed by Rivers et al (13) , an early hemodynamic resuscitation protocol, provided an evident decrease of mortality in patients with severe sepsis and septic shock.…”
Section: Discussionmentioning
confidence: 99%
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“…(13,14,(25)(26)(27)(28) There is evidence that therapeutic intervention with hemodynamic resuscitation and antibiotic therapy are associated to lower mortality rates. (7)(8)(9)(10)(11)(12)15) As such, agile and adequate treatment is the "mainstay" for a successful approach to severe sepsis. (18)(19)(20) Goal directed early therapy proposed by Rivers et al (13) , an early hemodynamic resuscitation protocol, provided an evident decrease of mortality in patients with severe sepsis and septic shock.…”
Section: Discussionmentioning
confidence: 99%
“…(7,8,(11)(12)(13)(14)(15)(16) At the second stage, even if there had not been a greater compliance to the bundles, mortality decreased considerably, showing that prognosis does not rely on compliance to the therapeutic bundles, but also on the earlier diagnosis.…”
Section: Discussionmentioning
confidence: 99%
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“…[7][8][9][10][11][12][13] There have also been questions concerning costs, pharmaceutical involvement and a one size fits all approach. [14][15][16][17] As part of the campaign, guidelines were developed by evaluating this research with a GRADE approach, a structured system for rating quality of evidence that also takes into account an assessment of the balance between benefits versus risks, burden, and cost. 18 …”
Section: Surviving Sepsis Campaign Backgroundmentioning
confidence: 99%
“…Despite intensive treatment with aggressive resuscitation, blood pressure control and adequate supply of oxygen, patients with sepsis often persist showing signs of tissue hypoperfusion, which can lead to acidosis and eventually multiple organ failure [2][3][4] . Researchers have shown that sepsis is characterized by decreased velocity of microcirculatory flow, increased flow heterogeneity, increasing vascular stasis and decreasing perfused capillaries 5,6 .…”
Section: Introductionmentioning
confidence: 99%