Early Histological Changes Following Obstruction of Pancreatic Ducts in Dogs: Correlation with Serum Amylase

Abstract

25178.1 mg, and 95.2, respectively. Three weeks after administration of glycine to these animals a mean fasting blood sugar of 101 mg was found. The same dose of insulin according to weight was then given and blood sugar determinations were made hourly. At the end of one hour the blood sugar was 39 mg. At the second, third, fourth, and fifth hours it was 37.4 ,mg, 48.5 mg, 63.5 mg, and 78.7 mg, respectively. This gives in rough figures a decrease of approximately 10 mg after the first hour and extending to the fif'th hour. In the case of animal No. 6 ( Fig. 2 ) the effect was somewhat more striking. Prior to the administration of glycine in this animal the fasting blood sugar was 110 mg. After administration of insulin the lowest blood sugar, 48 mg, as shown in the accompanying graph, occumed at the end of one hour. It rose gradually to 102 mg 5 hours after insulin. When retested 3 weeks after the administration of glycine, a fasting blood sugar of 113 mg was found. Following adsministration of insulin the lowest blood sugar level was 22 mg occurring 2 hours after insulin and rising to 89 mg 5 hours after insulin.There was considerable variation in the response of different animals. Rabbit No. 9, for m e reason not apparent had a consistently higher blood sugar following tYle administration of glycine than prior to it. If this animal is excluded, results are considerably more impressive.Why a normally occurring constituent of the body should have this effect or why it should have 'any effect when given in these relatively small a m n t s is not apparent. There are instances in which the body con-!trolling mechanism may be disrupted by the administration of excessive amounts of normally occurring substances.Summary. 1. The effect of parenteral administration of glycine in rabbits on the effect of insulin is reported. 2. Parenteral glycine under certain conditions renders rabbits more sensitive to insulin. ~ ~~

Concentration of Pancreozymin as a Determinant of the Exocrine-Endocrine Partition of Pancreatic Enzymes

“…BOCHMAN et al (1971) showed that retrograde infusions of ferritin with a pressure of 150 mmHg into the canine pancreatic duct revealed accumulation of ferritin in a periacinar space, although the injection pressure used exceeded by far the 'resting' pressure of the duct. GIBBS and IVY (1951) showed that serum amylase rose twice as fast in the dogs when the pancreatic duct system was subjected to a pressure of 30 cm H2O after ligation of the pancreatic duct.…”

A Model to Predict the Severity of Acute Pancreatitis Based on Serum Level of Amylase and Body Mass Index

“…In early animal studies the serum amylase levels was shown to correlate with the histological changes of AP (16). However, the serum amylase levels have not been shown to correlate with severity of disease in human subjects and severity scores were developed based on markers of inflammatory response and complications in other organ systems.…”

The Effects of Rhein and Honokiol on Metabolic Profiles in a Mouse Model of Acute Pancreatitis

“…Interestingly, serum amylase levels have long been used for AP diagnosis. Early animal studies showed that serum amylase levels were correlated with the histological changes of AP [ 23 ]. In the present study, we detected the level of serum amylase after rhein, honokiol, and rhein+honokiol treatment.…”