Early menarche in normal-weight girls and its association with excess weight, abdominal obesity and metabolic changes at the end of sexual maturation

Araújo, Maria Lúcia Diniz; Cabral, Poliana Coelho; Arruda, Ilma Kruze Grande de; Diniz, Alcides S.; Lemos, Manoel; Morais, Glaucia Queiroz

doi:10.1038/ejcn.2016.103

Cited by 4 publications

(5 citation statements)

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“…In a five-year longitudinal study with girls in the ideal weight range at the time of menarche, Araújo et al 3 found no statistically significant differences between girls with and without EM in terms of excess weight, abdominal obesity or abnormal serum lipid levels at the end of sexual maturity. Likewise, Must et al 28 conducted a longitudinal study and found that nutritional status in childhood exerted a greater influence on the occurrence of excess weight in adulthood than EM.…”

Section: Discussionmentioning

confidence: 97%

“…Depending on the study, EM is defined from 9 to less than 12 years of age 3,4,5 . According to Gaudineau et al 6 , this variability can be explained by the age of menarche found in different populations.…”

Section: Introductionmentioning

confidence: 99%

“…Most studies conducted in Brazil that have explored the relationship between menarche and nutritional status are limited to the investigation of its effect during the period of adolescence 3,8 . A study involving adult women in the southern region of the country found a protective effect of late menarche for obesity8.…”

Section: Introductionmentioning

confidence: 99%

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Early menarche and its association with anthropometric and body composition variables in young university students

et al. 2020

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Objective: Evaluate the association between early menarche and anthropometric/body composition variables in young female university students. Methods: Cross-sectional study involving female university students at a public university in northeastern Brazil. Anthropometric and body composition data were collected, along with a self-report of age at menarche. The conceptual model considered demographic, socioeconomic and lifestyle variables as well as the perception of weight in childhood and at menarche. Results: Among the 162 students analyzed, 62.3% were less than 20 years of age. The frequency of underweight and overweight was 8.6% and 22.3%, respectively. The frequency of above-average body fat and obesity was 32.1% and 14.8%, respectively. Early menarche was reported in 35.2%. The frequency of self-reported excess weight in childhood and at menarche was 31.3% and 25.9%, respectively. A statistically significant association was found between early menarche and height < 1st tertile (< 1.62 m). A tendency toward an association was found between early menarche and both weight, circumference in the risk range and the perception of excess weight in childhood and at menarche. Conclusion: Current excess weight was more associated with excess weight in childhood and at menarche than the occurrence of early menarche.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Early menarche and its association with anthropometric and body composition variables in young university students

et al. 2020

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“…Among the various reasons for these inconsistent findings in the studies of the literature, there are different methods to collect (status quo and recall) and report (mean or median values) the AAM data. Moreover, the age limits used to define early menarche vary depending on the research, even extending to include all those below the median age [ 54 ]. Finally, the cross-sectional design generally applied in these studies may have led to additional difficulties in interpreting the phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Age at Menarche, Growth Velocity, and Adiposity Indices in Italian Girls Aged 10 to 14

et al. 2022

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Age at menarche (AAM) is an effective marker of puberty timing but its onset could be influenced by several intrinsic and extrinsic factors. This study aimed to assess the AAM in a sample of Italian adolescents and to investigate its association with anthropometric variables. Considering the rise in overweight/obesity worldwide, special attention was paid to a possible decrease in AAM as adiposity indices increase. A longitudinal study was carried out on 117 middle school girls in Northern Italy. Data concerning menarche and anthropometric traits (standing and sitting height, weight, waist circumference, and skinfold thicknesses) were directly collected. Lower limb length and indices of adiposity and growth were calculated. The median AAM was 11.66 (95% IC: 11.31–11.68). Age-adjusted ANCOVA between mature and non-mature girls showed significant differences in growth-related traits and WHtR. No preponderance of overweight/obesity among mature participants was found. AAM was not significantly associated with weight or the growth velocity of adiposity indices in a subsample of maturers. Moreover, the median AAM of our sample was similar to that found in women born about 60 years ago in the same region. In conclusion, in addition to a stabilization of AAM since the 1960s, our results suggest that there is no significant correlation between increased adiposity and early AAM.

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“…Moreover, several studies have reported controversial results on the association between age at menarche and various cardiometabolic risk factors (6,(9)(10)(11). However, these relationships can be significantly affected by many factors such as ethnicity, geographical region, and socioeconomic status (12).…”

Section: Introductionmentioning

confidence: 99%

The association between early menarche and higher-risk cardiometabolic profile: a dose–response analysis of the Tabari cohort at enrollment phase

Kheradmand,

Hamzehgardeshi,

Shahhosseini

et al. 2023

Front. Cardiovasc. Med.

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ObjectivesThe association between age at menarche and higher-risk cardiometabolic factors is controversial and more strands of evidence are required. Therefore, in this study, we aimed to investigate the effect of early menarche on cardiometabolic profile in a large-scale cohort population.Study designData collected in the enrollment phase of the Tabari cohort study were utilized for the present study. We analyzed data from 6,103 women aged 35–70 years. Logistic regression and dose–response (trend) analyses were used to investigate the effect of early menarche on prevalence of diabetes, dyslipidemia, obesity, high waist circumference (WC), high waist-to-hip ratio (WHR), and high waist-to-height ratio (WHtR).ResultsThe results of the adjusted logistic regression analysis showed that women who experienced early menarche had significantly higher odds of obesity (odds ratio: 1.64, 95% CI: 1.36–1.99, P for trend <0.001), high WC (odds ratio: 1.34, 95% CI: 1.07–1.67, P for trend = 0.035), high WHR (odds ratio: 1.32, 95% CI: 1.05–1.66, P for trend = 0.057), and high WHtR (odds ratio: 1.83, 95% CI: 1.22–2.74, P for trend = 0.006) compared to those aged ≥14 at menarche. The prevalence of dyslipidemia was also higher among women who experienced early menarche than in women aged ≥14 at menarche (79.9% vs. 76.6%), but the difference was not statistically significant (P = 0.098). Additionally, each year of earlier menarche was significantly associated with an increase in the chance of diabetes (by 5%), obesity (10%), high WC (5%), and high WHtR (13%).ConclusionThe present study showed that early menarche is a strong predictor for later development of obesity and diabetes, and for high WC, WHR, and WHtR. Among all factors examined, age at menarche had the greatest predictive power for WHtR. As an age-dependent anthropometric index for central obesity, WHtR is more suitable as an index for identification of individuals with increased cardiometabolic risk.

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Early menarche in normal-weight girls and its association with excess weight, abdominal obesity and metabolic changes at the end of sexual maturation

Abstract: These findings suggest that early menarche did not influence weight, abdominal obesity and serum lipids in the final stage of sexual maturation.

Cited by 4 publications

References 36 publications

Early menarche and its association with anthropometric and body composition variables in young university students

Early menarche and its association with anthropometric and body composition variables in young university students

Age at Menarche, Growth Velocity, and Adiposity Indices in Italian Girls Aged 10 to 14

The association between early menarche and higher-risk cardiometabolic profile: a dose–response analysis of the Tabari cohort at enrollment phase

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