Early outcomes data for accelerated partial breast irradiation using balloon brachytherapy

Cuttino, L.W.; Vicini, Frank A.

doi:10.1586/era.11.113

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…Single-institution and registry studies reported to date with short follow-up show risks of local recurrence similar to those associated with wholebreast radiation. 24,25 Although the results of one population-based study in older women provides a cautionary note by showing that women treated with APBI have a higher rate of subsequent mastectomy than those treated with whole-breast radiation, this rate was still very low. 26 A national clinical trial comparing whole-breast radiation and APBI has enrolled thousands of women, but results will not be available for a few years.…”

Section: Radiation: More Of Lessmentioning

confidence: 99%

Advances in Breast Surgery, 2002-2012

Edge

2013

J Natl Compr Canc Netw

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The past 40 years have brought dramatic changes in breast cancer treatments, resulting in a 30% reduction in breast cancer mortality. This is largely the result of new concepts tested in a steady stream of large, well-designed, coordinated clinical trials. Early trials showed that extended surgery ("local therapy") does not improve mortality over less aggressive surgery. Trials conducted in the 1970s and 1980s clearly showed that radical surgery involving removal of the breast provides no outcome advantage over breast-conserving therapy (BCT). One concern with BCT has been a higher rate of local recurrence compared with mastectomy, with initial studies before the routine use of systemic therapy reporting rates of 10% to 20% with BCT. Modern series define a risk of local recurrence after BCT of 2% to 5%, about the same as with mastectomy. The improvement is partly due to improved standards in surgery, radiation oncology, and pathology. However, it is primarily due to the use of systemic endocrine and chemotherapy. BCT is appropriate for most women with breast cancer. This article explores the advancements in breast surgery over the past 10 years.

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Section: Radiation: More Of Lessmentioning

confidence: 99%

Advances in Breast Surgery, 2002-2012

Edge

2013

J Natl Compr Canc Netw

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“…This involves using fewer, larger-dose radiation or brachytherapy techniques to achieve the same effect. There are currently many trials which are assessing the effectiveness and safety of this procedure [17][18][19][20][21][22] . However, from preliminary data it seems reasonable to consider these methods as a valid alternative to omitting adjuvant radiotherapy in elderly patients with early stage breast cancer.…”

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confidence: 99%

Omission of adjuvant radiation therapy in elderly patients with low risk breast cancer undergoing breast-conserving surgery - two center experience

Vrána¹,

Gatěk²,

Lukešová³

et al. 2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Introduction. Breast cancer is, now often diagnosed in patients older than 70 years due to longer life expectancy. The usual treatment is mastectomy to obviate radiotherapy or breast-conserving surgery followed by radiotherapy. The aim of this study was to investigate the need for adjuvant radiotherapy in older patients and the consequences of omitting radiotherapy following conservative surgery.Methods. An extensive database search was made of patients who had been treated for breast cancer at the Department of Oncology, University Hospital Olomouc and the Atlas Hospital in Zlin (2004Zlin ( -2008. We identified 738 patients of whom 190 patients (25.7%) were older than 70 years of age. These were followed up for progression-free and overall survival. The cause of death was checked for breast cancer relapse. Results. In total only 9 patients undergoing breast saving surgery were ultimately identified. No patient had confirmed local recurrence during the follow up period: Two patients have died due to distant metastasis without local relapse and one patient has died for reasons other than breast cancer. Conclusion. Omitting radiotherapy after breast saving surgery provides an opportunity for women to undergo breast saving surgery and avoid 7 weeks of radiotherapy. This could significantly improve patient quality of life. In our of many years experience and from published randomized data, this procedure is safe for a select group of patients 70 years of age and older.

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