Early pospartum alexithymia and risk for depression: Relationship with serum thyrotropin, free thyroid hormones and thyroid autoantibodies

Donne, Maria Le; Salvatore, Silvia; Benvenga, Salvatore

doi:10.1016/j.psyneuen.2011.08.001

Cited by 32 publications

(26 citation statements)

References 72 publications

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“…In addition, these behavioral changes were accompanied by lower BDNF and 5-HT levels in the prefrontal cortex but no change in TT4 levels. These experiments provided further evidence for the association between TPOAb and PPD in an isolated TPOAb-positive mouse model, which was consistent with the clinical studies mentioned above (Kuijpens et al, 2001; Albacar et al, 2010; Le Donne et al, 2012). …”

Section: Discussionsupporting

confidence: 90%

“…A later, larger prospective follow-up study that enrolled 1,017 pregnant women from the general population indicated that TPOAb was related to major depression at 12 and 24 weeks of gestation but not at 36 weeks, when the downregulation of the immune system reached its maximum, and the occurrence of major depression declined with decreasing TPOAb titers throughout pregnancy (Pop et al, 2006). There was also evidence that the TPOAb titer was significantly higher in women at risk for PPD than those not at risk for PPD using three evaluation scales (Le Donne et al, 2012; Groer and Vaughan, 2013). However, in different study populations, other researchers found no association between TPOAb and depression (Engum et al, 2005; Albacar et al, 2010; Delitala et al, 2016), even during 1 week post-partum (Lambrinoudaki et al, 2010).…”

Section: Discussionmentioning

confidence: 97%

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Elevated Thyroid Peroxidase Antibody Increases Risk of Post-partum Depression by Decreasing Prefrontal Cortex BDNF and 5-HT Levels in Mice

Zhou

Wang²,

Zhao³

et al. 2017

Front. Cell. Neurosci.

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Post-partum depression (PPD) is a common mental disease in the perinatal period that profoundly affects mothers and their offspring. Some clinical studies have found that PPD is related to thyroid peroxidase antibodies (TPOAbs); however, the mechanism underlying this relationship is unclear. Female C57BL/6 mice immunized with adenovirus encoding the cDNA of the full-length mTPO (mTPO-Ad) were used to establish the isolated TPOAb-positive mouse model in the present study. Maternal depressive-like behaviors were assessed using the forced swimming test (FST), sucrose preference test (SPT), and tail suspension test (TST) post-partum. The serum TPOAb titer was measured by enzyme-linked immunosorbent assay (ELISA) before pregnancy and post-partum. Furthermore, in the prefrontal cortex, the mRNA and protein expression levels of brain-derived neurotrophic factor (BDNF) were measured, serotonin (5-HT) levels were measured by ultra-high-performance liquid chromatography–tandem mass-spectrometry (UHPLC–MS/MS), and total thyroxine (TT4) levels were determined by ELISA. Compared with the controls, the mice immunized with mTPO-Ad displayed depressive behaviors, with a significantly lower sucrose preference (SP) at the 12-h time point and a longer immobility time in the FST and TST, which were accompanied by a lower expression of BDNF and 5-HT but no change in the TT4 concentration in the prefrontal cortex. Together, these findings suggest that elevated TPOAb may increase the risk of subsequent PPD and decrease the concentration of BDNF and 5-HT in the prefrontal cortex.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Elevated Thyroid Peroxidase Antibody Increases Risk of Post-partum Depression by Decreasing Prefrontal Cortex BDNF and 5-HT Levels in Mice

Zhou

Wang²,

Zhao³

et al. 2017

Front. Cell. Neurosci.

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“…A growing appreciation of the mind-body connection in health and disease has led to an increased focus on biological processes that may underlie or contribute to the disorder (Albacar et al, 2010; Binder et al, 2010; Bloch et al, 2000; Corwin et al, 2003; Costas et al, 2010; Figueira et al, 2010; Goshtasebi et al, 2013; Guintivano et al, 2013; Kimmel et al, 2013; Le Donne et al, 2012; Maes et al, 2002; O'Keane et al, 2011). In the current study, our primary finding, that variability in the functioning of the bi-directional interactions between the immune-inflammatory response and the HPA axis within the first weeks after childbirth influences a woman's risk of PPD, further emphasizes the importance of an integrated PNI response in the postpartum mental health continuum.…”

Section: Discussionmentioning

confidence: 99%

Bidirectional psychoneuroimmune interactions in the early postpartum period influence risk of postpartum depression

Corwin

Pajer

Paul

et al. 2015

Brain, Behavior, and Immunity

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More than 500,000 U.S. women develop postpartum depression (PPD) annually. Although psychosocial risks are known, the underlying biology remains unclear. Dysregulation of the immune inflammatory response and the hypothalamic-pituitary-adrenal (HPA) axis are associated with depression in other populations. While significant research on the contribution of these systems to the development of PPD has been conducted, results have been inconclusive. This is partly because few studies have focused on whether disruption in the bidirectional and dynamic interaction between the inflammatory response and the HPA axis together influence PPD. In this study, we tested the hypothesis that disruption in the inflammatory-HPA axis bidirectional relationship would increase the risk of PPD. Plasma pro- and anti-inflammatory cytokines were measured in women during the 3rd trimester of pregnancy and on Days 7 and 14, and Months 1, 2, 3, and 6 after childbirth. Saliva was collected 5 times the day preceding blood draws for determination of cortisol area under the curve (AUC) and depressive symptoms were measured using the Edinburgh Postpartum Depression Survey (EPDS). Of the 152 women who completed the EPDS, 18% were depressed according to EDPS criteria within the 6 months postpartum. Cortisol AUC was higher in symptomatic women on Day 14 (p=.017). To consider the combined effects of cytokines and cortisol on predicting symptoms of PPD, a multiple logistic regression model was developed that included predictors identified in bivariate analyses to have an effect on depressive symptoms. Results indicated that family history of depression, day 14 cortisol AUC, and the day 14 IL8/IL10 ratio were significant predictors of PPD symptoms. One unit increase each in the IL8/IL10 ratio and cortisol AUC resulted in 1.50 (P=0.06) and 2.16 (P=0.02) fold increases respectively in the development of PPD. Overall, this model correctly classified 84.2% of individuals in their respective groups. Findings suggest that variability in the complex interaction between the inflammatory response and the HPA axis influence the risk of PPD.

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“…No association was found between thyroid autoantibodies and postpartum mood disorders by Lambrinoudaki et al (59). In another study, lower levels of serum FT3 were associated with increased incidence of mood disorders in the first postpartum week; only TPOAb and TgAb were significantly higher in women at risk for postpartum depression compared to women not at risk, using EPDS cutoff values of ≥13 or ≥14 (3). The presence of thyroid autoantibodies or higher TSH levels during the postpartum period may be related to depressive symptoms or dysphoric mood (56).…”

Section: Postpartum Mood Disorders and Thyroid Autoimmunitymentioning

confidence: 97%

“…Risk for postpartum depression and alexithymia showed a direct borderline statistically significant correlation with serum TPOAb, suggesting that these mood disorders could be neurobehavioral consequences of an autoimmune attack (because of the TPOAb circulation in the CSF and of their possible cross-reaction with cerebral autoantigens) (3). …”

Section: Postpartum Mood Disorders and Thyroid Autoimmunitymentioning

confidence: 99%

Postpartum Mood Disorders and Thyroid Autoimmunity

et al. 2017

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Early pospartum alexithymia and risk for depression: Relationship with serum thyrotropin, free thyroid hormones and thyroid autoantibodies

Cited by 32 publications

References 72 publications

Elevated Thyroid Peroxidase Antibody Increases Risk of Post-partum Depression by Decreasing Prefrontal Cortex BDNF and 5-HT Levels in Mice

Elevated Thyroid Peroxidase Antibody Increases Risk of Post-partum Depression by Decreasing Prefrontal Cortex BDNF and 5-HT Levels in Mice

Bidirectional psychoneuroimmune interactions in the early postpartum period influence risk of postpartum depression

Postpartum Mood Disorders and Thyroid Autoimmunity

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