Early Postoperative Use of Diuretics After Kidney Transplantation Showed Increase in Delayed Graft Function

Baar, Wolfgang; Kaufmann, Kai; Silbach, Kai; Jaenigen, Bernd; Pisarski, Przemyslaw; Goebel, Ulrich; Kalbhenn, Johannes; Heinrich, Sebastian; Knoerlein, Julian

doi:10.1177/1526924820913505

Cited by 3 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite some understanding about clinical factors promoting DGF, many issues remain poorly understood. Recently, in retrospective analyses similar to ours, early use of diuretics or large volumes of intravenous normal saline solution were reported to be associated with DGF [11,12]. In contrast, Chaumont et al [10] reported the absence of perioperative saline loading as predisposing to DGF.…”

Section: Discussionsupporting

confidence: 61%

Predictors of Delayed Graft Function in Renal Transplantation

et al. 2021

View full text Add to dashboard Cite

Purpose: This study aimed to analyze our data on delayed graft function (DGF) and to identify associated factors. Methods: This is a retrospective case-control study of all patients transplanted in our center over a period of 11 years (January 1, 2003, to December 31, 2014) comparing patients with immediate graft function (n = 332) to those with DGF (n = 165). DGF was defined as the need for hemodialysis within the first 7 days after transplantation. Donor and recipient characteristics as well as procedural factors were compared by univariate and multivariate logistic regression analyses. Results: Overall, 33% of patients had DGF. The rate of DGF declined from 2003 to 2011. In cases with DGF, donors and recipients were significantly older (p = 0.004 and p = 0.005, respectively), had longer cold ischemia times (p = 0.039), more revision surgeries (p < 0.001), and more HLA mismatches (p = 0.001), especially in the DR locus (p = 0.002). Neither donor nor recipient gender, waiting time, nor CMV status had any influence. In multivariable analysis, significant risk factors were ischemia time and mismatches at the HLA-DR loci. Conclusions: DGF is a common complication in renal transplantation which occurred in 33% of our cases. Important factors identified were donor and recipient age, ischemia time, HLA mismatching, and revision surgery.

show abstract

Section: Discussionsupporting

confidence: 61%

Predictors of Delayed Graft Function in Renal Transplantation

et al. 2021

View full text Add to dashboard Cite

show abstract

“…However, more recent studies, such as the study conducted by Baar et al, found a significant relationship between the use of diuretics during kidney transplantation and the incidence of DGF. Therefore, the use or non-use of diuretics in kidney transplantation remains a controversial issue (27,28). Studies that have attempted to predict GFR in transplanted kidneys by using the amount of diuresis have shown that only measuring the amount of diuresis is not enough to predict the one-year performance of the transplanted kidney (29).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Relationship between Diuresis and Kidney Function in Transplant Patients at Tabriz Imam Reza Hospital

2023

JMCCR

View full text Add to dashboard Cite

Introduction Kidney transplantation is the method of choice and a cost-effective treatment for ESRD patients, which has significantly reduced mortality and complications of the disease. In this study, we aim to investigate the effects of diuresis on renal function in transplant patients. The aim of this cross-sectional analysis is to find out the effects of diuresis on renal function in patients undergoing renal transplantation. Methods This cross-sectional study was conducted on kidney transplant patients at Tabriz Imam Reza Medical Education Center. During the study, patients were examined based on specific inclusion and exclusion criteria. Demographic information, including age, sex, morning weight the day before surgery, underlying disease, and duration of dialysis in years, was recorded. The study also included calculating the patients’ GFR using the CKD-EPI equation and determining its relationship with both recovery urinary output and 24-hour urinary output. Results This study included 49 patients who underwent kidney transplantation. The right and the left kidney was transplanted in 42 and 7 patients respectively. Present study showed that there was no significant relationship between the laboratory parameters of patients, including preoperative sodium, preoperative potassium, preoperative urea, preoperative creatinine, postoperative sodium, postoperative potassium, postoperative urea, postoperative creatinine, preoperative GFR, postoperative GFR, and diuresis of patients in the recovery room and 24 hours after surgery. Additionally, there was no significant relationship between indicators such as age and weight and the amount of diuresis of patients in the recovery room and 24 hours after the operation. Furthermore, this study did not find a significant difference in preoperative GFR, postoperative GFR, recovery output, and 24-hour output between patients with hypertension and the non-hypertensive group. Conclusion There was no significant relationship between demographic indicators and laboratory parameters and the amount of diuresis in patients. Additionally, the study found no significant difference in GFR and output between patients with hypertension and those without hypertension.

show abstract