Early weight bearing of porous HA/TCP (60/40) ceramics in vivo: A longitudinal study in a segmental bone defect model of rabbit

Structure control of hydroxyapatite ceramics via an electric field assisted freeze casting method

“…The component of hydroxyapatite (HA) is close to mineralized bones of human tissues. Thus the hydroxyapatite is suitable for orthopedic and dental applications [4,5]. Porous HA scaffold is beneficial to cell adhesion and proliferation [6].…”

Comparison of Three Dissolution Apparatuses for Testing Calcium Phosphate Pellets used as Ibuprofen Delivery Systems

“…Indeed, these bioceramics are biocompatible, bioactive, osteoconductive, and resorbable (25,26,29,30). Moreover, they can offer great interest as drug delivery systems (31)(32)(33)(34), achieving a therapeutic drug concentration directly at the site to be treated, while maintaining a low systemic drug level (35)(36)(37)(38). In order to evaluate the drug-substance release as well as the biocompatibility and the osteoconductivity of such delivery systems, in vivo studies must be carried out.…”

Technologies Applied to Stimulate Bone Regeneration

“…Unlike beta-tricalcium phosphate, hydroxyapatite (Ca 10 (PO 4 ) 6 (OH)2) a bioceramic with a low resorption rate and greater mechanical resistance, is commonly used in association with beta-tricalcium phosphate, in the proportion of 60/40 to improve osseointegration of the graft substitute (Balcik et al, 2007). The porosity of the biomaterial is essential for its action, requiring pores of 100-200µm, at a density of 60 to 65% for cellular lodging and vascularization of the treated area, confirming the osteoconductive action of hydroxyapatite (Giannoudis et al, 2005).…”