Nowadays, system designers have adopted Networks-on-Chip as communication infrastructure of general-purpose tile-based Multi-Processor System-on-Chip (MPSoC). Such decision implies that a certain topology has to be selected to efficiently interconnect many cores on the chip. To ease such a choice, the networking literature offers a plethora of works about topology analysis and characterization for the off-chip domain. However, theoretical parameters and many intuitive assumptions of such off-chip networks do not necessarily hold when a topology is laid out on a 2D silicon surface. This is due to the distinctive features of silicon technology design pitfalls. This work is a first milestone to bridge this gap, in fact, we propose a comprehensive analysis framework to assess k-ary n-mesh and C-mesh topologies at different level of abstractions, from system to layout level, while capturing implications of system and layout parameters across design hierarchy. When a certain topology proves to be slow due to long links crossing the chip, pipeline stages have been inserted to cope with such slow-down. Furthermore, costs of such speed-up technique have been evaluated to draw a comprehensive performance/area figure.The gap between the constraints driving the design of onchip vs. off-chip interconnection networks (and hence the gap between the final network architectures selected for use in each domain) is increasingly widening even more as an effect of the relentless pace of technology scaling to the nanoscale regime. New physical effects come into play and may either degrade performance/power in an unpredictable way or even affect feasibility of the design at hand or of specific architecture design techniques.Examples concern the large buffering cost associated with techniques borrowed from the off-chip domain (e.g., for congestion management strategies or for deadlock-free and multicast friendly switching mechanisms) which are not affordable in the on-chip domain. Moreover, the interconnect reverse scaling is making designs for on-chip integration increasingly interconnect-dominated, due to the delay associated with the shrinking cross-section area of on-chip interconnects. This effect becomes increasingly severe at each technology node and tends to widen the gap between post-synthesis and postplace&route performance figures and even to move critical path delays from logic blocks to large global wires.Selection of the topology connectivity pattern in the early stages of network design is a decision which is extremely sensitive to both the effects illustrated above. In fact, topologies for on-chip networks must match the 2D silicon surface, while off-chip realizations are dictated by board/rack organization. The 2D mapping constraint raises implementation issues such as wire crossings, wires of uneven length or the decrease of switch operating frequency with the number of I/O ports. As an ultimate consequence, topologies borrowed from off-chip networks should be reassessed in the on-chip environment and validated against...