ECG-Gated Three-dimensional Intravascular Ultrasound

Birgelen, C. von; Vrey, Evelyn A. de; Mintz, Gary S.; Nicosia, Antonino; Bruining, Nico; Li, W.; Slager, Cornelis J.; Roelandt, Jos R.T.C.; Serruys, Patrick W.; Feyter, Pim J. de

doi:10.1161/01.cir.96.9.2944

Cited by 172 publications

(48 citation statements)

References 47 publications

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“…12 Intraobserver and interobserver variabilities of this system have also been determined in clinical protocols. 9 Intraobserver variability assessed with analysis of the IVUS volumetric studies at intervals of Ն3 months has been reported: Ϫ0.4Ϯ1.1% in lumen volume, Ϫ0.4Ϯ0.6% in total vessel volume, and Ϫ0.3Ϯ1.0% in plaque volume with ECG-gated motorized pullback.…”

Section: Ivus Image Acquisition Analysis Systemmentioning

confidence: 99%

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Three-Dimensional Intravascular Ultrasound Assessment of Noninjured Edges of β-Irradiated Coronary Segments

et al. 2000

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Background-The "edge effect," late lumen loss at the margins of the treated segment, has become an important issue in the field of coronary brachytherapy. The aim of the present study was to assess the edge effect in noninjured margins adjacent to the irradiated segments after catheter-based intracoronary ␤-irradiation. Methods and Results-Fifty-three vessels were assessed by means of 3-dimensional intravascular ultrasound after the procedure and at 6-to 8-month follow-up. Fourteen vessels (placebo group) did not receive radiation (sham source), whereas 39 vessels were irradiated. In the irradiated group, 48 edges (5 mm in length) were identified as noninjured, whereas 18 noninjured edges were selected in the placebo group. We compared the volumetric intravascular ultrasound measurements of the noninjured edges of the irradiated vessels with the fully irradiated nonstented segments (IRS, nϭ27) (26-mm segments received the prescribed 100% isodose) and the noninjured edges of the vessels of the placebo patients. The lumen decreased (6 mm 3 ) in the noninjured edges of the irradiated vessels at follow-up (Pϭ0.001). We observed a similar increase in plaque volume in all segments: noninjured edges of the irradiated group (19.6%), noninjured edges of the placebo group (21.5%), and IRS (21.0%). The total vessel volume increased in the IRS in the 3 groups. No edge segment was subject to repeat revascularization. Conclusions-The edge effect occurs in the noninjured margins of radiation source train in both irradiated and placebo patients. Thus, low-dose radiation may not play an important role in this phenomenon, whereas nonmeasurable device injury may be considered a plausible alternative explanation.

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Section: Ivus Image Acquisition Analysis Systemmentioning

confidence: 99%

“…5,9 In brief, the segment subject to 3-D reconstruction was examined with a 30-MHz singleelement mechanical transducer IVUS system (ClearView, CVIS; Boston Scientific Corp). ECG-gated 3-D IVUS image acquisition and digitization were performed with a computerized workstation (EchoScan; TomTec).…”

Section: Ivus Image Acquisition Analysis Systemmentioning

confidence: 99%

Three-Dimensional Intravascular Ultrasound Assessment of Noninjured Edges of β-Irradiated Coronary Segments

et al. 2000

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“…Furthermore, individual patients were imaged with the same system at index and follow-up. 3D (ECG-gated) IVUS analysis 34 may be superior for the assessment of coronary dimensions and provides volumetric data. In addition, sophisticated computer-aided gray-scale IVUS analyses 15 or radiofrequency IVUS analyses 35 may be superior to visual IVUS analysis of plaque composition.…”

Section: Limitationsmentioning

confidence: 99%

Relation Between Progression and Regression of Atherosclerotic Left Main Coronary Artery Disease and Serum Cholesterol Levels as Assessed With Serial Long-Term (≥12 Months) Follow-Up Intravascular Ultrasound

et al. 2003

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“…As a tomographic imaging technique, intravascular ultrasound (IVUS) allows the visualization of atherosclerotic plaques in vivo. [2][3][4][5][6] In standard IVUS gray-scale images, calcified regions of plaque and dense fibrous components generally reflect ultrasound energy well and thus appear bright and homogeneous on IVUS images. Conversely, regions of low echo reflectance in IVUS images are usually labeled as "soft" or "mixed" plaque.…”

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confidence: 99%

Coronary Plaque Classification With Intravascular Ultrasound Radiofrequency Data Analysis

et al. 2002

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Background-Atherosclerotic plaque stability is related to histological composition. However, current diagnostic tools do not allow adequate in vivo identification and characterization of plaques. Spectral analysis of backscattered intravascular ultrasound (IVUS) data has potential for real-time in vivo plaque classification. Methods and Results-Eighty-eight plaques from 51 left anterior descending coronary arteries were imaged ex vivo at physiological pressure with the use of 30-MHz IVUS transducers. After IVUS imaging, the arteries were pressure-fixed and corresponding histology was collected in matched images. Regions of interest, selected from histology, were 101 fibrous, 56 fibrolipidic, 50 calcified, and 70 calcified-necrotic regions. Classification schemes for model building were computed for autoregressive and classic Fourier spectra by using 75% of the data. The remaining data were used for validation. Autoregressive classification schemes performed better than those from classic Fourier spectra with accuracies of 90.4% for fibrous, 92.8% for fibrolipidic, 90.9% for calcified, and 89.5% for calcified-necrotic regions in the training data set and 79.7%, 81.2%, 92.8%, and 85.5% in the test data, respectively. Tissue maps were reconstructed with the use of accurate predictions of plaque composition from the autoregressive classification scheme. Conclusions-Coronary plaque composition can be predicted through the use of IVUS radiofrequency data analysis.Autoregressive classification schemes performed better than classic Fourier methods. These techniques allow real-time analysis of IVUS data, enabling in vivo plaque characterization. (Circulation. 2002;106:2200-2206.)

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ECG-Gated Three-dimensional Intravascular Ultrasound

Abstract: ECG-gated acquisition of 3D IVUS image sets is feasible and permits the application of automated contour detection to provide reproducible measurements of the lumen and atherosclerotic plaque CSA and volume in a relatively short analysis time.

Cited by 172 publications

References 47 publications

Three-Dimensional Intravascular Ultrasound Assessment of Noninjured Edges of β-Irradiated Coronary Segments

Three-Dimensional Intravascular Ultrasound Assessment of Noninjured Edges of β-Irradiated Coronary Segments

Relation Between Progression and Regression of Atherosclerotic Left Main Coronary Artery Disease and Serum Cholesterol Levels as Assessed With Serial Long-Term (≥12 Months) Follow-Up Intravascular Ultrasound

Coronary Plaque Classification With Intravascular Ultrasound Radiofrequency Data Analysis

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