Echocardiographic Predictors of Exercise Capacity in Patients With Heart Failure and Systolic Dysfunction: Role of Mitral Regurgitation

Trivi, Marcelo; Thierer, Jorge; Kuschnir, Paola; Acosta, Adriana; Marino, Javier; Guglielmone, Ramiro; Ronderos, Ricardo

doi:10.1016/j.rec.2011.06.002

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…The ejection fraction was similar in both studied groups, but mitral regurgitation was more frequent in the group of patients with impaired exercise capacity which is similar to findings by Trivi (Trivi et al ., ), who also proved the influence of this valvular defect on physical capacity regardless of the LV function. Therefore, could the high percentage of patients with reduced physical capacity be the effect of frequent occurrence of MR during the acute phase of STEMI in the studied population.…”

Section: Discussionmentioning

confidence: 97%

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Factors determining exercise capacity evaluated during cardiopulmonary exercise testing in 6‐month follow‐up after ST elevation myocardial infarction

Turski

Kocierz-Woźnowska

Wybraniec

et al. 2019

Clin Physio Funct Imaging

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Summary Introduction ST elevation myocardial infarction (STEMI) is one of the main causes of congestive heart failure (CHF). The main symptom of CHF is exercise tolerance impairment. The aim of the study was to evaluate the prevalence and risk factors for impaired exercise tolerance in patients after STEMI. Methods and Results A total of 84 patients with STEMI were analysed in the study. Cardiopulmonary exercise test (CPET) was performed 6 months after STEMI. Impaired exercise tolerance defined as peak VO2 < 84% predicted for age and sex was present in 49 (58%) patients and was connected with lack of abciximab administration (91.4 versus 69%, P = 0·02) and the presence of mitral regurgitation (47 versus 23%, P = 0·02). In univariate analysis, the troponin I level at admission (OR 1·89, P = 0·047), the use of abciximab (OR 0·21, P = 0·03), the presence of mitral regurgitation (OR 2·98, P = 0·03) and NT‐proBNP concentration (OR 2·17, P = 0·021) were related to impaired exercise tolerance. The best multivariate model for predicting impaired exercise tolerance included mitral regurgitation and lack of abciximab administration. Conclusions Impaired exercise tolerance after STEMI is common. Mitral regurgitation and lack of abciximab administration are the best predicting factors of impaired exercise tolerance after STEMI.

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Section: Discussionmentioning

confidence: 97%

“…Therefore, could the high percentage of patients with reduced physical capacity be the effect of frequent occurrence of MR during the acute phase of STEMI in the studied population. This valvular defect has an influence on exercise tolerance regardless of LV function (Trivi et al ., ). MR is a frequent complication of myocardial infarction.…”

Section: Discussionmentioning

confidence: 97%

Factors determining exercise capacity evaluated during cardiopulmonary exercise testing in 6‐month follow‐up after ST elevation myocardial infarction

Turski

Kocierz-Woźnowska

Wybraniec

et al. 2019

Clin Physio Funct Imaging

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“…In this study, the median value of 6MWD at the time of hospital discharge was used to classify subjects into the two groups [19,20]. Because the median value of 6MWD at the time of discharge for the subjects of this study was 493 m, the subjects were classified into one group with a 6MWD of 493 m or more at the time of discharge (6MWD recovery group), and a second group with a 6MWD of 493 m or less (6MWD nonrecovery group).…”

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confidence: 99%

Evaluation of indices for predicting recovery of exercise tolerance in patients surviving allogenic hematopoietic stem cell transplantation

Hamada

Kondo

Harada

et al. 2022

Support Care Cancer

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“…In contrast, six-minute walking test (6-MWT) is an accurate, simple and reliable tool, which correlates closely with peak VO 2 . 15 A number of cardiac structure and function indexes have been shown as predictors of 6-MWT in HF including left ventricular (LV) systolic, 16,17 diastolic function, 18,19 mechanical dyssynchrony measurements, 20,21 RV function 22,23 and left atrial (LA) size. 24,25 However, the additional value of LA function disturbances particularly in patients with reduced RV function remains undetermined.…”

Section: Introductionmentioning

confidence: 99%

Left atrial compliance index predicts exercise capacity in patients with heart failure and preserved ejection fraction irrespective of right ventricular dysfunction

et al. 2019

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Background and Aim Predictors of exercise capacity in heart failure (HF) with preserved ejection fraction (HFpEF) remain of difficult determination. The aim of this study was to identify predictors of exercise capacity in a group of patients with HFpEF and right ventricle (RV) dysfunction Methods In 143 consecutive patients with HFpEF (age 62 ± 9 years, LV EF ≥45) and 41 controls, a complete echocardiographic study was performed. In addition to conventional measurements, LA compliance was calculated using the formula: [LAV max − LAV min/LAV min × 100]. Exercise capacity was assessed using the six‐minute walking test (6‐MWT). Tricuspid annular plane systolic excursion (TAPSE) < 1.7 cm was utilized to categorize patients with RV dysfunction (n = 40) from those with maintained RV function (n = 103). Results Patients with RV dysfunction were older (P = 0.002), had higher NYHA class (P = 0.001), higher LV mass index (P = 0.01), reduced septal and lateral MAPSE (all P < 0.001), enlarged LA (P = 0.001) impaired LA compliance index (P < 0.001) and exhibited a more compromised 6‐MWT (P = 0.001). LA compliance index correlated more closely with 6‐MWT (r = 0.51, P < 0.001) compared with the other LA indices (AP diameter, transverse diameter and volume indexed; r = −0.30, r = −0.35 and r = −0.38, respectively). In multivariate analysis, LA compliance index <60% was 88% sensitive and 61% specific (AUC 0.80, CI = 0.67–0.92 P = 0.001) in predicting exercise capacity. Conclusion An impairment in LA compliance was profound in patients with HFpEF and RV dysfunction and seems to be most powerful independent predictor of limited exercise capacity.

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Echocardiographic Predictors of Exercise Capacity in Patients With Heart Failure and Systolic Dysfunction: Role of Mitral Regurgitation

Cited by 6 publications

References 27 publications

Factors determining exercise capacity evaluated during cardiopulmonary exercise testing in 6‐month follow‐up after ST elevation myocardial infarction

Factors determining exercise capacity evaluated during cardiopulmonary exercise testing in 6‐month follow‐up after ST elevation myocardial infarction

Evaluation of indices for predicting recovery of exercise tolerance in patients surviving allogenic hematopoietic stem cell transplantation

Left atrial compliance index predicts exercise capacity in patients with heart failure and preserved ejection fraction irrespective of right ventricular dysfunction

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