Eco-friendly synthesis of gold nanoparticles (AuNPs) using Inonotus obliquus and their antibacterial, antioxidant and cytotoxic activities

Lee, K.D.; Nagajyothi, P.C.; Sreekanth, T.V.M.; Park, Soonheum

doi:10.1016/j.jiec.2014.11.016

Cited by 91 publications

(28 citation statements)

References 40 publications

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“…neoformans was susceptible to both AgNPs and AuNPs. We believe this is a relevant finding, since mainly antibacterial features of AuNPs have been demonstrated so far, [32][33][34] while the scientific literature is short on investigations into the potential antifungal feature of AuNPs. 35,36 Importantly, apart from their capacity to inhibit Cr.…”

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confidence: 74%

Biosynthesized silver and gold nanoparticles are potent antimycotics against opportunistic pathogenic yeasts and dermatophytes

Rónavári¹,

Igaz²,

Gopisetty³

et al. 2018

IJN

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Background Epidemiologic observations indicate that the number of systemic fungal infections has increased significantly during the past decades, however in human mycosis, mainly cutaneous infections predominate, generating major public health concerns and providing much of the impetus for current attempts to develop novel and efficient agents against cutaneous mycosis causing species. Innovative, environmentally benign and economic nanotechnology-based approaches have recently emerged utilizing principally biological sources to produce nano-sized structures with unique antimicrobial properties. In line with this, our aim was to generate silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) by biological synthesis and to study the effect of the obtained nanoparticles on cutaneous mycosis causing fungi and on human keratinocytes. Methods Cell-free extract of the red yeast Phaffia rhodozyma proved to be suitable for nanoparticle preparation and the generated AgNPs and AuNPs were characterized by transmission electron microscopy, dynamic light scattering and X-ray powder diffraction. Results Antifungal studies demonstrated that the biosynthesized silver particles were able to inhibit the growth of several opportunistic Candida or Cryptococcus species and were highly potent against filamentous Microsporum and Trichophyton dermatophytes. Among the tested species only Cryptococcus neoformans was susceptible to both AgNPs and AuNPs. Neither AgNPs nor AuNPs exerted toxicity on human keratinocytes. Conclusion Our results emphasize the therapeutic potential of such biosynthesized nanoparticles, since their biocompatibility to skin cells and their outstanding antifungal performance can be exploited for topical treatment and prophylaxis of superficial cutaneous mycosis.

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confidence: 74%

Biosynthesized silver and gold nanoparticles are potent antimycotics against opportunistic pathogenic yeasts and dermatophytes

Rónavári¹,

Igaz²,

Gopisetty³

et al. 2018

IJN

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“…These particles have a broad range of applications, such as catalysis, biosensing, optoelectronics, chemical sensing, and medical diagnosis [1]. Out of various nano-structured materials under research, gold nanoparticles (AuNPs) are of particular interest to scientific community owing to their stability, inertness, and potential applications in biotechnology [2].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and Biomedical Applications of Gold Nanoparticles Using Eclipta prostrata Leaf Extract

Rajakumar

Gomathi²,

Rahuman³

et al. 2016

Applied Sciences

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This study reports the biological synthesis of gold nanoparticles (AuNPs) by the reduction of HAuCl 4 by using of Eclipta prostrata leaf extract as the reducing and stabilizing agent. AuNPs were characterized using Ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), Fourier Transform-Infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), High Resolution-Transmission Electron Microscopy (HRTEM), and Energy Dispersive X-ray analysis (EDAX). The UV-visible spectrum of the synthesized AuNPs showed surface plasmon resonance (SPR) around 534 nm. The face-centered cubic (FCC) structure of the AuNPs was confirmed by XRD peaks at 38.10˝, 44.13˝, 64.43˝, and 77.32˝, which correspond to (111), (200), (220), and (311) miller indices, respectively, with clear circular spots in the selected area electron diffraction (SAED). FTIR measurements showed the AuNPs having a coating of phenolic compounds, indicating a possible role of biomolecules responsible for capping and efficient stabilization of the AuNPs. The HRTEM images determined the particles are spherical, hexagonal, and triangular in shape, with an average size of 31˘1.6 nm. The synthesized AuNPs show good antibacterial, antioxidant, and cytotoxic activity. The outcomes of this study indicate that these nanoparticles could be effectively utilized in pharmaceutical, biotechnological, and biomedical applications.

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“…Good examples of tested plant species are Azadirachta indica (Nazeruddin et al 2014), Delonix elata (Sathiya and Akilandeswari 2014), Tephrosia purpurea (Ajitha et al 2014), Argyreia nervosa (Saratale et al 2017), and many others (see Benelli 2016a for a recent review). The utilization of plant extracts has several advantages over microorganisms including lower costs and biohazards (Lee et al 2015;Devanesan et al 2016;Nirmala et al 2016). The various biomolecules present in the plant extract such as enzymes, flavonoids, and terpenoids act as reducing and capping agents for nanosynthesis (Gurunathan et al 2013;Velmurugan et al 2014).…”

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confidence: 99%

Exploiting fruit byproducts for eco-friendly nanosynthesis: Citrus × clementina peel extract mediated fabrication of silver nanoparticles with high efficacy against microbial pathogens and rat glial tumor C6 cells

Saratale

Shin

Kumar

et al. 2017

Environ Sci Pollut Res

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Process byproducts from the fruit industry may represent a cheap and reliable source of green reducing agents to be used in current bio-nanosynthesis. This study reports the use of orange (Citrus × clementina) peel aqueous extract (OPE) for one-pot green synthesis of silver nanoparticles (AgNPs) with high effectiveness against various microbial pathogens as well as rat glial tumor C6 cells. The effects of various operational parameters on the synthesis of AgNPs were systematically investigated. The morphology, particle size, and properties of synthesized AgNPs were characterized using UV-visible spectroscopy, x-ray diffraction, x-ray photoelectron spectroscopy, field emission scanning electron microscopy, energy-dispersive x-ray spectroscopy, and Fourier transform infrared spectroscopy. High-resolution transmission electron microscopy shows that the nanoparticles are mostly spherical in shape and monodispersed, with an average particle size of 15-20 nm. Notably, the OPE-synthesized AgNPs were stable up to 6 months without change in their properties. Low doses of OPE-AgNPs inhibited the growth of human pathogens Escherichia coli, Bacillus cereus, and Staphylococcus aureus. The minimum inhibitory concentration and minimum bactericidal concentration of AgNPs against selected pathogenic bacteria were determined. OPE-AgNPs exhibited strong antioxidant activity in terms of ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging (IC 49.6 μg/mL) and DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging (IC 63.4 μg/mL). OPE-AgNPs showed dose-dependent response against rat glial tumor C6 cells (LD 60 μg/mL) showing a promising potential as anticancer agents. Overall, the current investigation highlighted a cheap green technology route to synthesize AgNPs using OPE byproducts and could potentially be utilized in biomedical, cosmetic, and pharmaceutical industry.

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Eco-friendly synthesis of gold nanoparticles (AuNPs) using Inonotus obliquus and their antibacterial, antioxidant and cytotoxic activities

Cited by 91 publications

References 40 publications

Biosynthesized silver and gold nanoparticles are potent antimycotics against opportunistic pathogenic yeasts and dermatophytes

Biosynthesized silver and gold nanoparticles are potent antimycotics against opportunistic pathogenic yeasts and dermatophytes

Biosynthesis and Biomedical Applications of Gold Nanoparticles Using Eclipta prostrata Leaf Extract

Exploiting fruit byproducts for eco-friendly nanosynthesis: Citrus × clementina peel extract mediated fabrication of silver nanoparticles with high efficacy against microbial pathogens and rat glial tumor C6 cells

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