Ecology and Recognition in the Nematode—Nematophagous Fungus System

New Biologically Active Compounds from the Nematode-Trappmg Fungus Arthrobotrys oligospora Fresen

“…The coupling con stants between 3-H and 4-H in similar compounds with the same stereochemistry [for example isoepoxydon (5)] is in all reported cases close to 5.0 Hz [10], while the J3_4 in epoxydon (6 ) (in which the oxirane ring and the C-4 hydroxyl group are cis) is 2.5 Hz [11]. The J3_4 in oligosporon (1) is 4.8 Hz, suggesting that it has the same relative stereochemistry as isoepoxydon (5), and this is also in accordance with the NOESY correlation observed between 3-H and 4-H in oligosporon (1). The same J3_4 and NOESY correlations were also observed in the spectra of oligosporol A (2), and oligosporol B (3), as well as for triacetyloligosporol B (4), which suggests that the two reduced de rivatives exist in the same conformation as oligo sporon (1) and that they have the same relative C-4/C-5 stereochemistry (differing only at C-l).…”

“…Nematode-trapping fungi have been studied in great detail, due to their unique abilities to catch nematodes and other invertebrates by means of special trapping organs [1]. Trapped nematodes are never colonized by microorganisms other than the predators themselves [2].…”

Structures and Absolute Configurations of Antibiotics of the Oligosporon Group from the Nematode-trapping Fungus Arthrobotrys oligospora.

“…In parallel to the Germanwork, we have independently isolated oligosporon (1) and oligosporol B (3) from an Australian isolate of A. oligospora and established their Structures as (1) and (3).8) Furthermore, our strain yields a number of related antibiotics.…”

Structures of Flagranones A, B and C, Cyclohexenoxide Antibiotics from the Nematode-trapping Fungus Duddingtonia flagrans.

“…NMR data clearly establish the flagraiione nucleus as the corresponding 2-acetoxymethyl-5,6-epoxycyclohex-2-en-l,4-dione depicted in structure (2) ( Tables 2 and 3 Ac-CO b Assignments may be interchanged within groups. Flagranones A and B were tested for antimicrobial activity against a range of bacteria and fungi.…”