Military actions on the territory of Ukraine, the occupation of entire regions of our country, the displacement of the population and the loss of logistical connections and segments of the internal markets for goods and services have become a source of catastrophic threats for a large number of domestic economic entities. The possibilities of influencing the state of economic security of the enterprise during the formation and functioning of the organizational and economic management mechanism of the business entity, in the process of developing and optimizing organizational culture, etc., have been established. It is substantiated that the management of economic security is one of the areas of general management, it involves planning, organization, implementation and control of security-oriented solutions, i.e. it is closely combined by common goals with organizational activities and tools for their achievement. The coincidence of the goals of the enterprise's organizational and economic mechanism and its economic security system, which consist in achieving a high level of efficiency, profitability, and competitiveness of the enterprise in an environment full of risks, has been revealed. War risks for the state of economic security of enterprises, such as the destruction of non-current assets of the enterprise, occupation of markets, loss of customers in the occupied territories, destruction of infrastructure and logistics routes, displacement of persons who held important positions in the organizational structure of the enterprise, staff turnover due to increased migration processes, temporary work stoppages during air alarms or power outages, violation of partnership relations with enterprises from uncontrolled territories are generalized. Such areas of improvement of operational activities of enterprises such as optimization of personnel placement, restructuring of the organizational structure in the direction of highlighting the segment of online customer service, studying the possibility of moving business, opening branches and representative offices in new regions, revising the personnel policy and organizational culture of the enterprise, creating customer support departments, formation of temporary teams to work on and finding new partners, are proposed.