Economic burden of periodontitis in the United States and Europe: An updated estimation

Botelho, João; Machado, Vanessa; Leira, Yago; Proença, Luís; Chambrone, Leandro; Mendes, José João

doi:10.1002/jper.21-0111

Cited by 120 publications

(100 citation statements)

References 20 publications

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“…The global prevalence of severe periodontitis has been estimated at 11.2%, and the disease is ranked the sixth most prevalent disease worldwide (Tonetti et al 2017). The economic burden of periodontitis in the United States and Europe has been estimated as US$342 billion (Botelho et al 2021). Over the past 15 y, evidence has accumulated that periodontitis is linked with a range of systemic diseases such as diabetes, cardiovascular diseases, certain cancers, and dementia, suggesting that periodontal health is vital for good general health (Hajishengallis and Chavakis 2021).The identification of bacterial species that characterize a subgingival plaque dysbiotic signature started with the seminal cross-sectional study by Socransky et al (1998).…”

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confidence: 99%

The Type IX Secretion System and Its Role in Bacterial Function and Pathogenesis

et al. 2021

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Porphyromonas, Tannerella, and Prevotella species found in severe periodontitis use the Type IX Secretion System (T9SS) to load their outer membrane surface with an array of virulence factors. These virulence factors are then released on outer membrane vesicles (OMVs), which penetrate the host to dysregulate the immune response to establish a positive feedback loop of chronic, inflammatory destruction of the tooth’s supporting tissues. In this review, we present the latest information on the molecular architecture of the T9SS and provide mechanistic insight into its role in secretion and attachment of cargo proteins to produce a virulence coat on cells and OMVs. The recent molecular structures of the T9SS motor comprising PorL and PorM as well as the secretion pore Sov, together with advances in the overall interactome, have provided insight into the possible mechanisms of secretion. We propose the presence of PorL/M motors arranged in a circle at the inner membrane with bent periplasmic rotors interacting with the PorN protein. At the outer membrane, we envisage a slide carousel model where the PorN protein is driven around a circular track composed of PorK. Cargo proteins are transported by PorN to PorW and the Sov translocon just as slides are rotated to the projection window. Secreted proteins are proposed to then be shuttled along highways consisting of the PorV shuttle protein to an array of attachment complexes distributed around the cell. The cell surface attachment of cargo is a hallmark of the T9SS, and in Porphyromonas gingivalis and Tannerella forsythia, this attachment is achieved via covalent bonding to a linking sugar synthesized by the Wbp/Vim pathway. The cell-surface attached cargo are enriched on OMVs, which are then released from the cell.

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confidence: 99%

The Type IX Secretion System and Its Role in Bacterial Function and Pathogenesis

et al. 2021

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“…1 In 2018, the aggregate direct cost of periodontal diseases in the USA amounted to $3.49 billion, while the indirect costs caused by the disease were estimated to reach $154 billion. 2 These costs are likely to increase, as an aging population coupled with the longer retention of teeth will result in more patients affected by periodontal destruction.…”

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confidence: 99%

Viruses, periodontitis, and comorbidities

Teles

Collman

Mominkhan

et al. 2022

Periodontology 2000

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Seminal studies published in the 1990s and 2000s explored connections between periodontal diseases and systemic conditions, revealing potential contributions of periodontal diseases in the initiation or worsening of systemic conditions. The resulting field of periodontal medicine led to the publication of studies indicating that periodontal diseases can influence the risk of systemic conditions, including adverse pregnancy outcomes, cardiovascular and respiratory diseases, as well as Alzheimer disease and cancers. In general, these studies hypothesized that the periodontal bacterial insult and/or the associated proinflammatory cascade could contribute to the pathogenesis of these systemic diseases. While investigations of the biological basis of the connections between periodontal diseases and systemic conditions generally emphasized the bacteriome, it is also biologically plausible, under an analogous hypothesis, that other types of organisms may have a similar role. Human viruses would be logical “suspects” in this role, given their ubiquity in the oral cavity, association with periodontal diseases, and ability to elicit strong inflammatory response, compromise immune responses, and synergize with bacteria in favor of a more pathogenic microbial consortium. In this review, the current knowledge of the role of viruses in connecting periodontal diseases and systemic conditions is examined. We will also delve into the mechanistic basis for such connections and highlight the importance of those relationships in the management and treatment of patients.

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“…In 2018, the economic cost of periodontal disease was $154.06 billion in the U.S. and €158.64 billion in Europe [ 3 ]. Therefore, prevention and management of periodontal diseases associated with a large economic burden are necessary.…”

Section: Introductionmentioning

confidence: 99%

Association between Healthy Lifestyle (Diet Quality, Physical Activity, Normal Body Weight) and Periodontal Diseases in Korean Adults

Hwang

Jang

Park

2022

IJERPH

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This study aimed to investigate the association between healthy lifestyle (HLS; i.e., diet quality, physical activity, normal weight) and periodontal diseases in Korean adults. Studying this association may help inform future intervention programs aimed at preventing the development of periodontal diseases. Raw data of the Korea National Health and Nutrition Examination Survey (KNHANES) VII (2016–2018) were used. Data from 12,689 adults aged 19 years and over who had a periodontal examination were analyzed. The associations between HLS and periodontal diseases were analyzed using multivariate logistic regression after adjusting for demographic and health factors as covariates. We found that each of the HLS (diet quality, physical activity, normal body weight) practices was significantly associated with periodontal diseases (OR: 1.32, 95% CI: 1.13–1.55; OR: 1.16, 95% CI: 1.04–1.30; OR: 1.26, 95% CI: 1.14–1.40, respectively). In particular, having poor HLS practices was identified as a risk factor for periodontal diseases (OR: 1.54, 95% CI: 1.10–2.15). HLS was associated with periodontal diseases. Thus, in addition to improving oral hygiene—the primary focus in the past—improving HLS should be emphasized for patients with periodontal diseases.

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Economic burden of periodontitis in the United States and Europe: An updated estimation

Cited by 120 publications

References 20 publications

The Type IX Secretion System and Its Role in Bacterial Function and Pathogenesis

The Type IX Secretion System and Its Role in Bacterial Function and Pathogenesis

Viruses, periodontitis, and comorbidities

Association between Healthy Lifestyle (Diet Quality, Physical Activity, Normal Body Weight) and Periodontal Diseases in Korean Adults

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