The potential costs of road traffic accidents (RTAs) to society are immense. Yet, no study has attempted to examine the impact of climate change on RTAs in Saudi Arabia, though RTA-leading deaths are very high, and the occurrence of climatic events is very frequent. Therefore, this study aims to assess the impact of climate change on RTAs in Saudi Arabia and to recommend some climate change mitigation and adaptation policies to make roads safe for all. This study employed annual data from 13 regions of Saudi Arabia, from 2003 to 2013. The data were analyzed on the basis of panel regression models-fixed effect, random effect, and the pooled ordinary least square. The findings show that temperature, rainfall, sandstorms, and number of vehicles were statistically and significantly responsible for RTAs in Saudi Arabia in the study period. This study also found that RTAs both inside and outside cities significantly caused injuries, but only RTAs inside cities significantly caused death. Furthermore, the death from RTAs injuries was found to be statistically significant only for motor vehicle accidents. The findings will assist policymakers in taking the right courses of action to mitigate the negative impacts of climate change through understanding climate influence on RTAs.