The article describes agricultural technologies increasing nitrate nitrogen content in the soil, crop yield, protein content and its fractional composition in winter wheat grain in the Middle Volga region. An economic and energy assessment of the effectiveness of winter wheat cultivation is provided for various predecessors, methods of primary tillage and fertilizing. Long-term studies were carried out on the fields of the Department of Agriculture, the laboratory “Agroecology” of Samara State Agricultural Academy. When cultivating winter wheat using the black fallow method, without autumn mechanical tillage with double application of nitrogen fertilizing, the highest yield indicators (2.79 t/ha), protein content of 13.12 %, the maximum net income, profitability of 92 % and energy efficiency were achieved. The energy efficiency coefficient in crops was the largest with the lowest energy coefficient in proteins.