Ectasia coronaria: prevalencia, características clínicas y angiográficas

Bermúdez, Eduardo Pinar; Palop, Ramón Lopéz; Martínez-Luengas, Íñigo Lozano; Sánchez, R. Cortés; Sáez, Pilar Carrillo; Carreras, Raúl Rodríguez; Aracil, Francisco Picó; Chávarri, Mariano Valdés

doi:10.1016/s0300-8932(03)76902-4

Cited by 78 publications

(33 citation statements)

References 21 publications

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“…This gender difference has been reported previously [ 38 , 81 ] and supposed due to the lower incidence of CAD in women, although the relation between CAE and CAD is not fully understood [ 32 ]. Moreover, the higher likelihood of males having CAE compared with women is generally consistent with a study in Spain in which male gender was demonstrated as an independent factor that increased the hazard of CAE [ 11 ]. Age has been shown to constitute a significant factor that is inversely associated with the presence of CAE [ 32 ].…”

Section: Cardiovascular Risk Factors and Coronary Artery Ectasiasupporting

confidence: 88%

“…Age has been shown to constitute a significant factor that is inversely associated with the presence of CAE [ 32 ]. A similar finding of significantly younger age among patients with CAE compared to those without CAE has previously been reported [ 11 , 21 , 82 ]. On the other hand, Markis et al [ 53 ] have reported comparable sex and mean age in patients with CAE and patients with CAD.…”

Section: Cardiovascular Risk Factors and Coronary Artery Ectasiasupporting

confidence: 87%

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Novel insights into an old controversy

Yetkın

Waltenberger

2007

Clin Res Cardiol

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Coronary artery ectasia (CAE) is defined as a localized or diffuse non-obstructive lesion of the epicardial coronary arteries with a luminal dilation exceeding 1.5-fold the diameter of the normal adjacent arterial segment. The incidence of CAE has been reported to range between 2% and 4%, which might be an overestimation of the true frequency. The coincidence of CAE with other systemic vascular dilatations has suggested that the mechanism underlying CAE is not only localized to coronary arteries, but also to other vascular compartments such as aorta or peripheral veins. Although the pathophysiology of CAE remains largely unknown, it was supposed to represent a variant of coronary atherosclerosis. This review focuses on this controversy of whether CAE and coronary artery disease (CAD) are two manifestations of the same underlying process. There are clear differences between CAD and CAE with respect to cardiovascular risk factors such as diabetes mellitus, and pathogenic steps in disease progress such as inflammation or extracellular matrix remodeling. As this review will underscore, the current knowledge of the field is insufficient to finally clarify the causative interrelation between CAE and CAD. The clinical course and treatment of CAE mainly depends on its coexistence with CAD. When coexisting with CAD, the prognosis and treatment of CAE are the same as for CAD alone. In isolated CAE, prognosis is better and anti-platelet drugs are the mainstay of treatment. Surgical treatment can be considered in selected patients. For clarifying the mechanism underlying CAE, additional clinical, histopathological and pathophysiological investigations are required. In fact, every patient with CAE should be evaluated systematically for pathological changes in other vascular territories, both in the arterial system as well as in the venous system, which might occur in the disease process.

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Section: Cardiovascular Risk Factors and Coronary Artery Ectasiasupporting

confidence: 88%

Section: Cardiovascular Risk Factors and Coronary Artery Ectasiasupporting

confidence: 87%

Novel insights into an old controversy

Yetkın

Waltenberger

2007

Clin Res Cardiol

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“…Consistent with those studies, we observed no relationship between isolated CAE and control group in terms of gender and presence of DM. On the other hand, another study by Pinar Bermúdez et al (25) found that CAE was more common in men and was negatively correlated with DM. However, unlike our patients, that study group was not limited to isolated CAE, but also included a substantial number of patients with severe angiographic stenosis.…”

Section: Discussionmentioning

confidence: 89%

Association with serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris

et al. 2019

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Association between serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris Objective: Dilation of one or more coronary artery segments to a diameter at least 1.5 times that of a normal adjacent segment is referred to as coronary artery ectasia (CAE). Adropin is a protein involved in endothelial function and is shown to have a protective effect on the regulation of cardiac functions. Atherosclerosis and endothelial dysfunction play an important role in the development of CAE. The aim of this study was to investigate the association between serum adropin levels and isolated CAE. Methods: Patients with stable angina pectoris who underwent coronary angiography (CAG) between August 2017 and July 2018 were evaluated prospectively. A total of 92 subjects were included in the study-40 patients over 18 years old and diagnosed with isolated CAE based on CAG findings and a control group of 52 patients. Results: Serum adropin level was found to be significantly lower in the isolated CAE group compared to the control group (1019.57 pg/mL and 1151.10 pg/mL, respectively, p=0.010). The isolated CAE group also exhibited a significantly higher mean platelet volume than that in the control group (10.75 fL and 10.17 fL, respectively, p=0.011). Conclusion: Our results show that there is an association between low serum adropin level and isolated CAE.

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“…CAE is a relatively rare abnormality of the coronary arterial tree and it is considered to be detected in 0.3-5.3% of consecutive angiographic series [2,3]. The etiopathogenesis of CAE is completely unclear and more than half of the cases have been reported to be associated with coronary atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Coronary Artery Stenoses, Markis Class, and Ectasia Ratio in Patients with Coronary Artery Ectasia

Zhang

Huang²,

Li³

et al. 2015

Cardiology

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Objectives: To assess the prognostic value of coexisting coronary artery disease (CAD), Markis class, and ectasia ratio for major adverse cardiovascular events in patients with coronary artery ectasia (CAE). Methods: A total of512consecutive patients with angiographically proven CAE were enrolled. Coronary ectasia extent was graded using the Markis class, and ectasia severity was assessed based on the ectasia ratio. Patients were followed up for a median of 34.6 months. Results: In the current study, 76 cases had isolated CAE, while the remaining 436 cases had coexisting CAD (mixture CAE). Males (84.4%) were predominantly affected, and the right coronary artery (55.1%) was most commonly involved. During follow-up, 86 overall major adverse cardiovascular events were diagnosed. Kaplan-Meier analysis failed to reveal any differences between isolated and mixture CAE in both cumulative and event-free survival analyses (p = 0.429 and p = 0.277, respectively). Moreover, when patients were divided into 4 groups according to Markis class (type I-IV) or 2 groups based on the ectasia ratio (1.5-2.0 and >2.0), there was no significant difference in survival outcomes among the groups (p > 0.05). Conclusions: In this follow-up study with a relatively large sample, the survival rate of patients with CAE appeared to be independent of coexisting CAD and ectasia extent and severity.

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Ectasia coronaria: prevalencia, características clínicas y angiográficas

Cited by 78 publications

References 21 publications

Novel insights into an old controversy

Novel insights into an old controversy

Association with serum adropin levels and isolated coronary artery ectasia in patients with stable angina pectoris

Prognostic Value of Coronary Artery Stenoses, Markis Class, and Ectasia Ratio in Patients with Coronary Artery Ectasia

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