Ectomesenchymal Chondromyxoid Tumor in the Anterior Tongue: Case Report of a Unique Tumor

Pak, Min Gyoung; Kim, Kyung Bin; Shin, Nari; Kim, Woo Kyung; Shin, Dong Hoon; Choi, Kyung Un; Sol, Mee Young

doi:10.4132/koreanjpathol.2012.46.2.192

Cited by 7 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ECT is an exceedingly rare tumor, with 60 cases published in the literature to our knowledge. 2-8,12-33 The tumor affects almost equally males and females, aged 7 to 78 years (median 37 years). 2 Although the vast majority of ECT occurs on the dorsal aspect of the anterior tongue, there were 6 cases arising in the posterior tongue and on the hard palate.…”

Section: Discussionmentioning

confidence: 99%

Cyclin D1 Expression in Ectomesenchymal Chondromyxoid Tumor of the Anterior Tongue

et al. 2016

View full text Add to dashboard Cite

Ectomesenchymal chondromyxoid tumor (ECT) is a rare benign tumor of uncertain lineage, which almost exclusively affects the anterior tongue. Herein, we report 2 cases of ECT occurring in 58- and 56-year-old males on the right and on the left side of the dorsum of the anterior tongue, measuring 18 mm and 10 mm, respectively. Despite positive resection margin in one case, none of the tumors recurred during follow-up of 6 and 5 years. Microscopically, both tumors had lobular architecture with a mixture of solid, microcystic, and chondromyxoid areas. The tumor cells were polygonal or elongated and showed mild atypia in one case. Immunohistochemically, both tumors showed diffuse expression of vimentin and focal positivity of CD10 and of smooth muscle actin. Regarding neural tissue-related markers, there was nearly diffuse expression of CD56 and neuron-specific enolase and focal positivity of PGP 9.5 in both cases and variable expression of CD57, synaptophysin, glial fibrillary acidic protein, and S-100 protein. Interestingly, we observed diffuse expression of SOX10 in one case. In both tumors, diffuse strong nuclear expression of cyclin D1 was present, without CCND1/IGH translocation or CCND1 amplification. The EWSR1 gene rearrangement was not detected. To the best of our knowledge, expression of SOX10, which may support neural crest origin of this peculiar lesion, has not been reported in ECT. The significance of strong cyclin D1 expression remains to be further investigated.

show abstract

Section: Discussionmentioning

confidence: 99%

Cyclin D1 Expression in Ectomesenchymal Chondromyxoid Tumor of the Anterior Tongue

et al. 2016

View full text Add to dashboard Cite

show abstract

“…1 – 3 , 5 – 31 Entrapment of the adjacent skeletal muscle was found in 44 lesions. 1 , 2 , 5 , 8 , 12 – 19 , 21 , 26 – 29 …”

Section: Review Of the Literaturementioning

confidence: 99%

Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report

et al. 2018

View full text Add to dashboard Cite

Prompted by a unique case of an ectomesenchymal chondromyxoid tumor (ECT) of the palate in a 54-year-old female, we reviewed the English and German literature on this entity until the end of 2016 using PubMed. The search produced 74 lingual cases with a nearly equal sex distribution and a mean age of 39.3 years, and two extra-lingual cases sharing histological and immunohistological features including nodular growth, round, fusiform or spindle-shaped cellular architecture, and chondromyxoid stroma. Immunophenotyping showed the majority of cases to be positive for glial fibrillary acidic protein (GFAP), S-100 protein, glycoprotein CD57, pancytokeratin (AE1/AE3), and smooth muscle actin (SMA); in isolated cases there was molecular-genetic rearrangement or gain of Ewing sarcoma breakpoint region 1 (EWSR1) but no rearrangement of pleomorphic adenoma gene 1 (PLAG1). At present, ectomesenchymal cells that migrate from the neural crest are considered to play a pivotal role in tumor origin. All cases had a benign course, although there were three recurrences. Because of the rarity of this tumor and the need for differential diagnostic differentiation from myoepithelioma and pleomorphic adenoma, both oral surgeons and pathologists should be aware of this entity.

show abstract

“…Ectomesenchymal chondromyxoid tumor is histopathologically characterized by the lobular proliferation of ovoid and fusiform cells with occasional foci of atypia in a chondromyxoid background and absence of these features eliminated this diagnosis. [ 41 ] Absence of microscopic features such as irregular nuclear morphology, aberrant intercellular matrix formation, increased cellularity, mitoses, and invasion into surrounding tissues ruled out the malignant Cartilaginous neoplasms. [ 24 ] Granular cell tumor was ruled out due to the absence of accumulation of plump cells with abundant granular cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

Chondroid choristoma of the tongue

Nezam

Nishat

Khan

et al. 2022

National Journal of Maxillofacial Surgery

View full text Add to dashboard Cite

Choristomas are tumor-like masses consisting of normal cells in an abnormal location. Choristomas of the oral cavity are rare lesions. We report a case of Cartilaginous choristoma on the ventral aspect of the tongue in a 25-year-old female. Clinical features, differential diagnosis, and tumoral origin theories are also discussed along with a meta-analysis of the reported cases in the PubMed database.

show abstract

Ectomesenchymal Chondromyxoid Tumor in the Anterior Tongue: Case Report of a Unique Tumor

Cited by 7 publications

References 13 publications

Cyclin D1 Expression in Ectomesenchymal Chondromyxoid Tumor of the Anterior Tongue

Cyclin D1 Expression in Ectomesenchymal Chondromyxoid Tumor of the Anterior Tongue

Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report

Chondroid choristoma of the tongue

Contact Info

Product

Resources

About