Ectopic expression of gastrokine 1 in gastric cancer cells up-regulates tight and adherens junction proteins network

Rippa, Emilia; Altieri, Filomena; Stadio, Chiara Stella Di; Miselli, Giuseppina; Lamberti, Annalisa; Federico, Antonella; Quagliariello, Vincenzo; Papale, Ferdinando; Guerra, Germano; Arcari, Paolo

doi:10.1016/j.prp.2015.04.008

Cited by 12 publications

(8 citation statements)

References 29 publications

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“…It is clearly demonstrated and previously described that VEGF, as well as many other growth factors, utilize are able to activate neoangiogenesis utilizing Ca2+ signaling toolkit which regulates EPCs biological properties like differentiation, proliferative rate, migration and vessel tube formation. Intracellular Ca2+ signals toolkit could be manipulate to repair damaged tissue using genetically transformed cells or represent the target site of cell based therapy through the impairment of EPC-dependent vasculogenesis and adverse tumour neovascularization [ 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 ]. Also MSC are useful to reduce a lesion because they could be able to stop the process of fibrosis, apoptosis, and could be responsible to induce mitosis in intrinsic cellular progenitors [ 193 ].…”

Section: Mscs Application In Cardiovascular Regenerative Therapymentioning

confidence: 99%

Cell based therapeutic approach in vascular surgery: application and review

et al. 2017

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AbstractMultipotent stem cells - such as mesenchymal stem/stromal cells and stem cells derived from different sources like vascular wall are intensely studied to try to rapidly translate their discovered features from bench to bedside. Vascular wall resident stem cells recruitment, differentiation, survival, proliferation, growth factor production, and signaling pathways transduced were analyzed. We studied biological properties of vascular resident stem cells and explored the relationship from several factors as Matrix Metalloproteinases (MMPs) and regulations of biological, translational and clinical features of these cells. In this review we described a translational and clinical approach to Adult Vascular Wall Resident Multipotent Vascular Stem Cells (VW-SCs) and reported their involvement in alternative clinical approach as cells based therapy in vascular disease like arterial aneurysms or peripheral arterial obstructive disease.

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Section: Mscs Application In Cardiovascular Regenerative Therapymentioning

confidence: 99%

Cell based therapeutic approach in vascular surgery: application and review

et al. 2017

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“…Beside the important role in gastric mucosal protection 1,4,5 , the biological reason for the antiamyloidogenic properties of human GKN1 and for its role in APP processing in gastric tissues is unclear. One explanation might be assigned to the BRICHOS domain acting in general as a chaperon toward peptides with a tendency to asssume β-strand structure.…”

Section: Gkn1 and Its Role In App Processingmentioning

confidence: 99%

“…GKN1 plays a central role in maintaining the integrity of the gastric mucosa and to facilitate its repair after damage 4,5 . The protein is localized mainly within the granules just under the apical plasma membrane.…”

Section: Introductionmentioning

confidence: 99%

Human Gastrokine 1 and its anti-amyloidogenic properties

Stadio¹,

Altieri²,

Minopoli³

et al. 2017

J Neurol Neuromedicine

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Gastrokine 1 (GKN1) is a 18 kDa stomach protein highly expressed in normal gastric tissue but absent in gastric cancer. GKN1 plays its major role in maintaining gastric mucosal integrity. Because of the presence in its central region of a BRICHOS domain, GKN1 is characterized by multifunctional properties since it interacts and regulates the activity of several proteins. The BRICHOS domain consists of about 100 amino acids and has been found in protein families often associated with major human diseases like familial British and Danish dementia (BRI2) or respiratory distress syndrome (surfactant protein C) (SP-C), both associated with amyloid formation. It has been shown that BRICHOS is a chaperon domain that has the property of binding precursor protein regions with high β-sheet tendencies, thereby preventing them from amyloid formation. Like the BRICHOS domains from BRI2 and SP-C precursor (proSP-C), also GKN1 is able to prevent fibrils formation of amyloidbeta peptide (Aβ) and to interact with the C-terminal region of APP thus hindering the γ-secretase proteolytic sites. Indeed, amyloid is of great medical importance since it originates in several major fatal diseases such as Alzheimer, Parkinson and diabetes mellitus. The results collected until now on the BRICHOS properties of GKN1 and those from other BRICHOS suggest that the different amyloids recognized by BRICHOS should contain similar structural elements therefore, the BRICHOS domain represents a potential powerfull tool for therapeutic approaches against amyloid associated diseases.

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“…GKN1 is a protein secreted by SMCs of the gastric antrum and fundus (6), which contributes to maintaining gastric homeostasis, inhibits inflammation and acts as a tumor suppressor (7)(8)(9)(10)(11)(12)(13)(14)(15)(16). The expression of GKN1 decreases due to H. pylori infection, inflammation or atrophy, and is absent in gastric cancer (17)(18)(19)(20)(21)(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Regulation of GKN1 expression in gastric carcinogenesis: A problem to resolve (Review)

et al. 2019

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Gastrokine 1 (GKN1) is a protein expressed on the surface mucosa cells of the gastric antrum and fundus, which contributes to maintaining gastric homeostasis, inhibits inflammation and is a tumor suppressor. The expression of GKN1 decreases in mucosa that are either inflamed or infected by Helicobacter pylori, and is absent in gastric cancer. The measurement of circulating GKN1 concentration, the protein itself, or the mRNA in gastric tissue may be of use for the early diagnosis of cancer. The mechanisms that modulate the deregulation or silencing of GKN1 expression have not been completely described. The modification of histones, methylation of the GKN1 promoter, or proteasomal degradation of the protein have been detected in some patients; however, these mechanisms do not completely explain the absence of GKN1 or the reduction in GKN1 levels. Only NKX6.3 transcription factor has been shown to be a positive modulator of GKN1 transcription, although others also have an affinity with sequences in the promoter of this gene. While microRNAs (miRNAs) are able to directly or indirectly regulate the expression of genes at the post-transcriptional level, the involvement of miRNAs in the regulation of GKN1 has not been reported. The present review analyzes the information reported on the determination of GKN1 expression and the regulation of its expression at the transcriptional, post-transcriptional and post-translational levels; it proposes an integrated model that incorporates the regulation of GKN1 expression via transcription factors and miRNAs in H. pylori infection.

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Ectopic expression of gastrokine 1 in gastric cancer cells up-regulates tight and adherens junction proteins network

Cited by 12 publications

References 29 publications

Cell based therapeutic approach in vascular surgery: application and review

Cell based therapeutic approach in vascular surgery: application and review

Human Gastrokine 1 and its anti-amyloidogenic properties

Regulation of GKN1 expression in gastric carcinogenesis: A problem to resolve (Review)

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