Ectopic Production of an Alkaline Phosphatase Isoenzyme in Patients with Cancer

Immunohistochemical and biochemical study of alkaline phosphatase in bone tumors and tumorous conditions - With special notes on giant cells.

“…The isoenzymes of ALPase found in tumor tissues were of the bone-type (ALPS) in all patients, and no cancer specific placenta-like ALPase such as Regan isoenzyme (28) in malignant tumors. This is probably because the properties of the cells of origin are preserved to a greater extent in bone malignancies than in other undifferentiated carcinomas.…”

Biochemical Monitoring of Cancer: A Review

“…More recent studies, however, with different methodologies have failed to confirm such a significant number of elevated isoenzyme levels (Jacoby and Bagshawe, 1972;Usategui-Gomez et al, 1973;Cadeau et al, 1974), so that the general and wide applicability once considered appropriate is now less certain. In addition early studies considered that the elevated levels were directly related to the tumour mass (Stolbach et al, 1969) but this is now open to doubt. Nathanson and Fishman (1971) noted that it could serve as a useful agent to judge the efficacy of surgery and/or chemotherapy in some cases of carcinomas of the ovary, breast, colon, and pancreas while also reflecting, by rising titres in other patients, disease progression and therapeutic refractoriness.…”

Inappropriate production of collagen and prolyl hydroxylase by human breast cancer cells in vivo

“…CEA and a-foetoprotein (Laurence and Neville, 1972) and enzymes, e.g. alkaline phosphatase (Stolbach, Krant and Fishman, 1969), all of which have been detected in the tumour and blood of patients with a variety of neoplasms. Some tumours also produce inappropriate proteins which are not secreted into the blood but are found only in the tumour itself (Yachi et al, 1968).…”