Edaravone attenuates lung injury in a hind limb ischemia-reperfusion rat model: A histological, immunohistochemical and biochemical study

Kassab, Amira Adly; Aboregela, Adel Mohamed; Shalaby, Abdalla

doi:10.1016/j.aanat.2019.151433

Cited by 22 publications

(15 citation statements)

References 44 publications

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“…[60,82] This may be due to oxidative stress, which could provoke activation of NF-κB that is a major inducer for classically activated proinflammatory macrophages, and COX-2 which regulates proinflammatory eicosanoids formation by promoting lung inflammation. [25] These results were consistent with previously published articles. [29,77,78] In the present study, a significant decline in both XO and LDH activities, as well as PC levels, was detected when EDA was administered to VPA-given rats.…”

Section: Discussionsupporting

confidence: 93%

The effects of edaravone, a free‐radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters

Bayrak

Yılmaz

Cakmak

et al. 2021

J Biochem & Molecular Tox

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In this study, we aimed to evaluate whether edaravone (EDA) has a protective role against valproic acid (VPA)-induced lung damage via its antioxidative activity. Male Sprague-Dawley rats were split into four groups. Control (n = 8) rats; rats given EDA (30 mg kg −1 day −1 ; n = 10); rats given only (VPA, 500 mg kg −1 day −1 ; n = 10); rats given VPA + EDA (in the same dose and time) for 7 days. EDA and VPA were applied intraperitoneally. After 8 days, lung tissues were immediately taken from the rats. In lung homogenates, reduced glutathione, total antioxidant status levels, and superoxide dismutase, glutathione peroxidase, sodium/potassium ATPase, paraoxonase1, and carbonic anhydrase activities significantly abated, whereas catalase, glutathione reductase, glutathione-S-transferase activities insignificantly decreased in the VPA-treated group. In contrast, lipid peroxidation, reactive oxygen species, and total oxidant status levels, glycoprotein and protein carbonyl contents, nitric oxide, hydroxyproline levels, and xanthine oxidase, lactate dehydrogenase, arginase, and prolidase activities significantly increased in the VPA-given group. Administration of EDA caused the reverse effects. As a consequence, EDA prevented oxidative stress-mediated lung injury via its robust antioxidant effects.

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Section: Discussionsupporting

confidence: 93%

The effects of edaravone, a free‐radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters

Bayrak

Yılmaz

Cakmak

et al. 2021

J Biochem & Molecular Tox

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“…A previous study showed that there were many signalling pathways participating in the progression of lung injuries induced by limb ischaemia-reperfusion. 13 Curcumin is a chemical constituent extracted from the rhizomes of some plants of the Zingiberaceae and Araceae families. 14 Studies have shown that curcumin is the effective substance found in turmeric and it possesses various pharmacological effects, including antioxidant, antitumour and antiinflammatory.…”

Section: Discussionmentioning

confidence: 99%

The mechanism of curcumin post-treatment relieving lung injuries by regulating miR-21/TLR4/NF-κB signalling pathway

Zou

Sun

2020

J Int Med Res

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Objective To investigate the mechanism by which curcumin prevents lung injury in a rat model of limb ischaemia-reperfusion injury. Methods Rats were randomized into four groups ( n = 20): control group (sham group); ischaemia-reperfusion group (I/R group); curcumin group (I/R+Cur group); and inhibitor of agomir-21 group (I/R+Cur+antagomir-21 group). At 3 h after reperfusion, lung tissues were collected for histopathology and immunohistochemistry to determine the apoptosis index (AI). Lung injury score (LIS) and lung wet/dry (W/D) ratio were determined. Lung microRNA-21 (miR-21) mRNA levels were measured using reverse transcription–polymerase chain reaction. Toll-like receptor 4 (TLR4) and nuclear factor kappa-B p65 (NF-κB p65) protein levels were measured by Western blot analysis. Tumour necrosis factor (TNF)-α and interleukin (IL)-1β levels were determined by enzyme-linked immunosorbent assays. Results In the I/R group, the W/D, LIS, AI, miR-21 mRNA, TLR4, NF-κB p65, TNF-α and IL-1β were significantly increased and the PaO2 was decreased compared with the sham group. Evidence of lung injury was observed in the I/R group and this was alleviated in the I/R+Cur group. An inhibitor of miR-21 (antagomir-21) reversed the protective effects of curcumin. Conclusion Curcumin post-treatment can alleviate the lung injuries induced by limb ischaemia-reperfusion via downregulating the levels of miR-21 mRNA.

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“…First, previous studies have showed that reactive oxygen species (ROS) and the inflammatory cytokines play an important role in the pathogenesis of ischemia-reperfusion induced lung injury [27,28], and several protective agents have been introduced to target these. In a hind limb I/R model in rats, edaravone exert a potent protective effect against lung injury induced through its antioxidant and anti-inflammatory activities [29]. Another animal study has also shown that Lazaroid U-74389G (an anti-lipid peroxidation drug) can reduce lung ischemia-reperfusion injury once the thoracoabdominal aortic occlusion has been relieved [10], and remains an avenue of future research.…”

Section: Discussionmentioning

confidence: 99%

Accumulative occlusion time correlates with postoperative pulmonary complications in patients undergoing pelvic and sacrum tumor resection assisted by abdominal aortic balloon occlusion: a retrospective cohort study

Zhao

Zhang

et al. 2020

BMC Musculoskelet Disord

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Background: Postoperative pulmonary complications (PPCs) seems to be high in patients undergoing pelvic and sacrum tumor resection assisted by abdominal aortic balloon occlusion. We hypothesized that the accumulative occlusion time (AOT) of the abdominal aortic balloon may be predictive of PPCs. The objective of the study was to identify the influence of AOT on PPCs. Methods: Retrospectively analyzed perioperative factors of 584 patients who underwent pelvic and sacrum tumor resection assisted by abdominal aortic balloon occlusion in our hospital from January 1, 2016 to December 31, 2018. PPCs including suspected pulmonary infection, atelectasis, pulmonary edema, pleural effusion, respiratory failure were clinically diagnosed. Perioperative parameters among patients with and without PPCs were compared. A receiver operating characteristic (ROC) analysis was conducted to evaluate the discriminative power of AOT with regard to PPCs. A multivariate logistic-regression model was finally established to identify independent risk factors for PPCs. Results: The incidence of PPCs was 15.6% (91 patients). The median AOT in PPCs group was significantly higher than that in non-PPCs group (P < 0.001). The hospital stay was significantly prolonged in PPCs group (P < 0.001). The ROC analysis showed an AOT of 119 min as the threshold value at which the joint sensitivity (88.60%) and specificity (31.87%) was maximal. Finally, AOT ≥ 119 min (P = 0.046; odds ratio (OR) = 2.074), age (P < 0.001; OR = 1.032), ASA grade III (P = 0.015; OR = 3.264), and estimated blood loss (P = 0.022; OR = 1.235) were independent risk factors of PPCs by multivariate logistic regression analysis.

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Edaravone attenuates lung injury in a hind limb ischemia-reperfusion rat model: A histological, immunohistochemical and biochemical study

Cited by 22 publications

References 44 publications

The effects of edaravone, a free‐radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters

The effects of edaravone, a free‐radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters

The mechanism of curcumin post-treatment relieving lung injuries by regulating miR-21/TLR4/NF-κB signalling pathway

Accumulative occlusion time correlates with postoperative pulmonary complications in patients undergoing pelvic and sacrum tumor resection assisted by abdominal aortic balloon occlusion: a retrospective cohort study

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