Edaravone Protects against Pancreatic and Intestinal Injury after Acute Pancreatitis <i>via</i> Nuclear Factor-κB Signaling in Mice

Abstract

Acute pancreatitis (AP) is one kind of acute surgical abdominal disease in the world. It causes intestinal damage with subsequent bacterial migration, endotoxemia and secondary pancreatic infections. In this investigation, we determined that edaravone (EDA) reduces pancreatic and intestinal injury after AP in mice. This was demonstrated by a reduction in histological score, apoptosis, interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α, along with obstructing activation of Toll-like receptor 4 (TLR4) and nuclear factor-κB (NFκB). Our study results suggested that EDA exerts its protective effects against pancreatic and intestinal injury after AP via regulation of the TLR4/NFκB pathway. Our findings provide the basis for EDA to treat AP-induced pancreatic and intestinal injury, even might develop as a potential therapy for other inflammatory diseases.

Strategies for Biomaterial-Based Spinal Cord Injury Repair via the TLR4-NF-κB Signaling Pathway

“…Fan et al fabricated a nanocomposite hydrogel loaded with alginate and eudradit nanoparticles, which improved stability and solubility of contained edaravone and maximized ROS sequestration, facilitating wound healing in diabetic mice ( Fan et al, 2019 ). The alginate hydrogel promoted sustained release of edaravone, which could suppress the production of pro-inflammatory factors by inhibiting the activation of TLR4 and NF-κB ( Fan et al, 2019 ; Wang and Lin, 2020 ). Poly-lactide-co-glycolide (PLGA) has been popularlyutilized as nanoccarriers owing to its favorable biocompatibility and biodegradability.…”

Therapeutic Effects of Edaravone on Azoospermia: Free Radical Scavenging and Autophagy Modulation in Testicular Tissue of Mice

“…The antioxidant properties of edaravone work by inactivating hydroxyl radical (OH) and thus, inhibiting the OH-dependent and OH-independent lipid peroxidation by supplying individual free-radicals with one of its electrons. Several reports have shown that edaravone as a potent scavenger of hydroxyl radicals has anti-apoptotic, anti-necrotic, anti-cytokine, and anti-autophagy effects in various diseases in the brain ( 11 ), heart ( 12 ), lungs ( 13 ), liver ( 14 , 15 ), testis ( 15 ), kidneys ( 16 ), pancreas ( 17 ), and small intestine ( 18 ) in animal models. Furthermore, as demonstrated in a recent study, edaravone treatment significantly relieved morphological damage and increased lipid peroxidation and apoptosis in testicular tissue by suppressing increased oxidative stress in the diabetes-induced testicular dysfunction in the rat ( 15 ).…”