Educational Case: Burn Injury—Pathophysiology, Classification, and Treatment

Noorbakhsh, Seth; Bonar, Eric M.; Polinski, Rachel; Amin, Shahrier

doi:10.1177/23742895211057239

Cited by 17 publications

(10 citation statements)

References 22 publications

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“…Luka bakar dapat disebabkan oleh panas atau trauma akut lainnya, seperti listrik, bahan kimia, gesekan, atau radiasi [4]. Perbedaan penyebab luka bakar dapat dikaitkan dengan respon fisiologis dan patofisiologis serta menentukan pendekatan terapi pengobatan yang dilakukan.…”

Section: Hasil Dan Pembahasanunclassified

Flavonoid dalam Penyembuhan Luka Bakar pada Kulit

et al. 2023

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Burns can be caused by heat or other acute trauma, currently the number of cases is still high in Indonesia and the world. The advances of burns treatment are made through research on possible natural ingredients. Flavonoids are polyphenolic compounds that are most commonly found in plants and as well as possible in burn healing. The aims of this literature review are decribed burns, histological structure of skin, and the effectiveness of flavoinoids in burns healing. The method used in this literature review is by searching data through the Science Direct, PubMed, and Google chrome databases. The search results of 19 appropriate journals, it was found that the flavonoid compounds can heal burns through their ability to inhibit prostanoid biosynthesis, inhibition of phosphodiesterase, and various other important mechanisms.

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Section: Hasil Dan Pembahasanunclassified

Flavonoid dalam Penyembuhan Luka Bakar pada Kulit

et al. 2023

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“…Burns encompass a range of intensity of injury determined by the profundity of the maim and the quantity or percentage of the burn of the whole body [22]. Burn has been categorized as superficial (first degree), partial thickness (second degree), and total thickness (third degree), involving just the epidermal layer of the skin, damaging to deeper structures within the skin, and all layers of the skin, respectively [23][24][25]. It has been reported that burns have the possibility to damage structures beneath the skin and deeper tissues.…”

Section: Categories Of Burnmentioning

confidence: 99%

Pediatric First-Degree Burn Management With Honey and 1% Silver Sulfadiazine (Ag-SD): Comparison and Contrast

Moniruzzaman¹,

Khan²,

Haq³

et al. 2022

Cureus

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BackgroundThe cardinal area of managing fire wounds is guided by adequately evaluating the burn-induced lesion's profundity and size. Superficial second-degree burns are often treated through daily reinstating with fresh sterile bandaging with appropriate topical antimicrobials to allow rapid spontaneous epithelialization. Around the world, a wide variety of substances are used to treat these wounds, from honey to synthetic biological dressings. ObjectiveThis study intended to determine honey's therapeutic potential compared with 1% silver sulfadiazine (Ag-SD) in arsenal-caused contusion medicament fulfillment. MethodsA total of 70 cases were evaluated in this research work after fulfilling the required selection criteria during the study period of January 2014 to December 2014 and January 2017 to December 2017. Purposive selection criteria were adopted in the study to select research patients. The patients in Group-1 (n = 35) relied on honey as medication, while patients in Group-2 (n = 35) relied on 1% Ag-SD. ResultsIn Group-1, exudation (68.4%) and sloughing (82.9%) were substantially reduced by Days 3 and 5 of therapeutic intervention, respectively. However, in Group-2, a reduction of exudation (17.1%) and sloughing (22.9%) occurred after Days 3 and 5 of treatment, respectively. Completion of the epithelialization process was observed among Group-1 and Group-2 cases. It was detected after Days 7 and 10 of treatment at 36.3% and 77% (Group-1) and 27% and 67% (Group-2), respectively. Around 3 ml of 1% honey was required per body surface area per dressing in Group-1. On the other hand, in Group-2, 2 gm Ag-SD was needed per body surface area per dressing. ConclusionPatients treated with honey found better clinical outcomes in managing superficial partial-thickness burns.

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“…In the third-degree burns (full-thickness) as the most serious type, the injury will exceed beyond the dermis layer and reach into the hypodermis 2 . The wound healing process consists of several critical steps comprising hemostasis, inflammation, proliferation and wound remodeling 3 , 4 . The mechanisms underlying the mentioned steps are as follows: (i) growth factors and inflammatory mediators; (ii) cell–cell and cell–extracellular matrix interactions that govern cell migration, proliferation, and differentiation; (iii) events involved with epithelialization, fibroplasia and angiogenesis; (iv) wound contraction; and (v) remodeling 5 .…”

Section: Introductionmentioning

confidence: 99%

Preclinical evaluation of the polycaprolactone-polyethylene glycol electrospun nanofibers containing egg-yolk oil for acceleration of full thickness burns healing

Shadman-Manesh

Gholipour-Kanani

Najmoddin

et al. 2023

Sci Rep

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Considering the great potential of egg yolk oil (EYO) in management of burn wounds and superb biological properties of polycaprolactone (PCL) and polyethylene glycol (PEG), hereby, a PCL-PEG-EYO scaffold was developed by electrospinning method for burn healing. The physico-chemical characterizations were performed using SEM, FTIR and contact angle tests. The biological properties of the fabricated scaffolds were evaluated by antibacterial test, in vitro cell culturing, MTT assay and in vivo experiments. The SEM images of PCL-PEG-EYO nanofibers demonstrated a uniform bead-free morphology with 191 ± 61 nm diameter. The fabricated scaffold revealed hydrophilicity with the water contact angel of 77°. No cytotoxicity was observed up to 7 days after cell culturing onto the PCL-PEG-EYO nanofibrous surface. The presence of EYO in the PCL-PEG-EYO scaffold meaningfully improved the cell viability, proliferation and attachment compared to PCL-PEG scaffold. Moreover, the PCL-PEG-EYO scaffolds demonstrated antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa bacteria strain. Finally, a statistically significant enhancement in wound closure, re-epithelialization, angiogenesis and collagen synthesis was observed at the end of 21-day treatment period using PCL-PEG-EYO nanofibrous scaffold. Overall, the PCL-PEG-EYO nanofibrous scaffolds demonstrated a great potential in management of full thickness burn wounds in vivo.

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Educational Case: Burn Injury—Pathophysiology, Classification, and Treatment

Cited by 17 publications

References 22 publications

Flavonoid dalam Penyembuhan Luka Bakar pada Kulit

Flavonoid dalam Penyembuhan Luka Bakar pada Kulit

Pediatric First-Degree Burn Management With Honey and 1% Silver Sulfadiazine (Ag-SD): Comparison and Contrast

Preclinical evaluation of the polycaprolactone-polyethylene glycol electrospun nanofibers containing egg-yolk oil for acceleration of full thickness burns healing

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