Efek Antidiabetes Kombinasi Ekstrak Bawang Putih (Allium sativum Linn.) dan Rimpang Kunyit (Curcumma domestica Val.) dengan Pembanding Glibenklamid pada Penderita Diabetes Melitus Tipe 2

Setiawan, Ame Suciati; Yulinah, Elin; Adnyana, I Ketut; Permana, Hikmat; Sudjana, Primal

doi:10.15395/mkb.v43n1.41

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…Curcumin sebagai antidiabetes menurunkan kadar glukosa darah yang diinduksi aloksan. Curcumin pada dosis rendah dapat mencegah terjadinya katarak yang disebabkan galaktosa dan menurunkan glikasi berat pada penderita diabetes mellitus (Setiawan, 2011).…”

Section: Ganguan Kesehatan Yang Dapat Terjadi Padaunclassified

Pengaruh Pemberian Jahe, Kunyit dan Salam Terhadap Kadar Asam Urat dan Glukosa Darah pada Bebek

Sulistyoningsih

Rakhmawati

Septiyanto

2018

JPI

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Penelitian ini bertujuan untuk mengetahui pengaruh pemberian tambahan herbal jahe, kunyit dan salam untuk menurunkan kadar asam urat dan glukosa darah pada bebek. DOD bebek subyek unsex 100 ekor. Perlakuan pada penelitian ini adalah P0 (pakan kontrol), P1 (pakan + jahe 2%), P2 (pakan + daun salam 3%) dan P3 (pakan + kunyit 0,2%) dengan empat ulangan. Penelitian ini menggunakan rancangan percobaan Rancangan Acak Lengkap (RAL). Data dianalisis dengan ANOVA dilanjutkan dengan uji Duncan jika berbeda nyata antar perlakuan. Hasil penelitian pemberian tambahan herbal jahe, kunyit dan salam tidak memberikan pengaruh (P> 0,05) terhadap kadar asam urat dan glukosa darah.

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Section: Ganguan Kesehatan Yang Dapat Terjadi Padaunclassified

Pengaruh Pemberian Jahe, Kunyit dan Salam Terhadap Kadar Asam Urat dan Glukosa Darah pada Bebek

Sulistyoningsih

Rakhmawati

Septiyanto

2018

JPI

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“…Pemeriksaan organoleptis meliputi bentuk, warna, PENDAHULUAN PEMANFAATAN tanaman sebagai bahan pengobatan telah menjadi kebudayaan hampir setiap negara di dunia. Salah satu tanaman yang mempunyai khasiat obat adalah bawang putih (Allium sativum L.) yang mengandung allicin (diallyl tiosulfonate atau diallyl disulfi de) (1) . Penelitian yang dilakukan oleh Rana et al (2) menunjukkan pemberian ekstrak metanol bawang putih pada konsentrasi 400 mg/ kgBB mempunyai efek menurunkan kadar glukosa darah mencit.…”

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Peningkatan Laju Difusi Allisin dalam Sistem Fitosom Ekstrak Bawang Putih

Amalia¹,

Elfiyani²,

Chenia³

2021

jifi

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Garlic (Allium sativum L.) contains allicin, which has the biological activity of reducing blood sugar levels. The results of previous studies stated that the methanol extract of garlic was able to reduce blood sugar levels in mice with a dose of 400 mg/kg BW. Allicin permeability of extract can be increased by formulating it into the phytosome system. The objective of this study is to determine the eff ect of allicin loaded phytosome on the diff usion rate of allicin. Garlic extract phytosome was made using a thin layer hydration method which was then evaluated for its physicochemical properties which included testing of entrapment effi ciency, density, particle size, index polydispersion, and the zeta potential. Determination of the value of the diff usion rate of allicin in the extract and the phytosome system was carried out using a modifi ed diff usion cell for 420 minutes. The phytosome system formed has an entrapment effi ciency value of 64.8789 % with a density of 1.0051 g/mL, a particle size of 270 nm, the zeta potential of -32.55 mV, and a polydispersion index of 0.571. Diff usion rate testing indicates the phytosome system can increase the diff usion rate of allicin when compared to the diff usion rate of allicin in garlic extract.

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Allicin Chemical Stability Test in the Phytosome of Garlic Extract (Allium sativum L)

Elfiyani

Amalia

Chenia

2021

IOP Conf. Ser.: Earth Environ. Sci.

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Allicin contained in garlic extract is unstable at high temperatures. Meanwhile, this compound has the potential to be widely used as an antidiabetic. One way to optimize the use of allicin is by using a phytosome delivery system that can protect allicin so that it does not degradation easily. The purpose of this study was to determine the storage temperature which indicates the slow rate of degradation of allicin in the phytosomes of garlic extract (PGE). PGE were stored for 8 weeks at 4°C, 25°C and 40°C. Allicin content were measured every 2 weeks using a UV-Vis spectrophotometer. The results of the degradation rate of allicin in PGE at temperatures of 40C; 250C; 400C were 0.0191; 0.0185; 0.0212, respectively. Based on these results, it can be concluded that the storage temperature of 250C showed the degradation rate of allicin in the PGE is slower than the other storage temperatures.

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Efek Antidiabetes Kombinasi Ekstrak Bawang Putih (Allium sativum Linn.) dan Rimpang Kunyit (Curcumma domestica Val.) dengan Pembanding Glibenklamid pada Penderita Diabetes Melitus Tipe 2

Cited by 5 publications

References 9 publications

Pengaruh Pemberian Jahe, Kunyit dan Salam Terhadap Kadar Asam Urat dan Glukosa Darah pada Bebek

Pengaruh Pemberian Jahe, Kunyit dan Salam Terhadap Kadar Asam Urat dan Glukosa Darah pada Bebek

Peningkatan Laju Difusi Allisin dalam Sistem Fitosom Ekstrak Bawang Putih

Allicin Chemical Stability Test in the Phytosome of Garlic Extract (Allium sativum L)

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