Efek Pemberian Virgin Coconut Oil (Cocos nucifera) terhadap Dislipidemia pada Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diberi Diet Tinggi Kolesterol

Venty, Augus; Aman, I Gusti Made; Pangkahila, Wimpie

doi:10.22225/wmj.1.2.28.58-65

Cited by 5 publications

(10 citation statements)

References 15 publications

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“…This is because a high-cholesterol diet can increase cholesterol synthesis in the liver through increasing the activity of the HMG-CoA enzyme, which is the catalyst of the first step in cholesterol biosynthesis, causing an increase in LDL cholesterol levels in the blood (Dean, 2013). This study is in line with research conducted by Venty (2017) where the result of his research stated that administration of 0.8 Ml OF vco/day to male white Wistar rats fed a high-cholesterol diet was able to reduce lipid profile.…”

Section: Discussionsupporting

confidence: 91%

Effect of Virgin Coconut Oil Administration to Increase HDL, Decrease LDL and IL-6 in Hypercholesterol Male Wistar Rats

Maulidia

Wibowo²,

Sumarawati³

2022

INDONES J MED

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Background: Hypercholesterol is a change in blood lipid profile levels, from rising cholesterol levels that can be triggered by frequent consumption of fatty foods. Hypercholeerol causes adipose tissue and macrophages to release inflammatory cytokines, then adipose cells release IL-6 and spur the formation of CRP. This study in aimed to determine the effect of Virgin coconut oil (VCO) on changes in HDL, LDL, and IL-6 levels in hypercholesterol mice. Subjects and Method: This was randomized controlled trial was carried out at the PSPG UGM Nutrition Laboratory in August 2021. The sample total number of samples used was 20 tails and 4 spare tails, namely 24 samples male wistar strain rats. Sampling using simple random sampling. The independent variables in this study were the dose of VCO 0.9 ml/200g BW/day, and 0.45 ml/200g BW/day. The dependent variables in this study were HDL, LDL, and IL-6 cholesterol levels in male Wistar rats. The data in the analysis used a normality test with the Shapiro Wilk test and a data homogeneity test with the Levane test. HDL dan LDL levels were measured using a dyasis reagent, while IL-6 was measured using ELISA method. Results: Average LDL and HDL levels are highest in the P1 group compared to the P2, K0, and K1 groups. The One Way Anova test on HDL levels showed a significant difference between groups with a value of p<0.001. One Way Anova test results on LDL and IL-6 levels showed significant differences between the groups (p<0.001) and (p= 0.004). Conclusion:Administering VCO at a dose of 0.9 mL/ 200 g BB/day 0.45 mL/200 g BB/day, and 86.4 mg/200 g can increase HDL and IL-6 levels in male rats wistar strain with hypercholesterol and lowered LDL levels by the same dose in male mice with hypercholesterol.

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Section: Discussionsupporting

confidence: 91%

Effect of Virgin Coconut Oil Administration to Increase HDL, Decrease LDL and IL-6 in Hypercholesterol Male Wistar Rats

Maulidia

Wibowo²,

Sumarawati³

2022

INDONES J MED

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“…The time range of VCO administration which is 1 week is assumed to be less significant in reducing TG levels. 1,8,13 The simvastatin-only group when compared to the positive control group showed an insignificant difference in the TG levels. The dose of simvastatin used in mice has also been converted using the Laurence and Bacharach conversion table, which is 0.2 mg/day.…”

Section: Discussionmentioning

confidence: 93%

The Effect of Simvastatin and Virgin Coconut Oil (VCO) Combination Therapy as Triglyceride Plasma Lowering Agent in White Dyslipidemic Male Rat (Rattus norvegicus)

Caesario

Soelistijo

Qurnianingsih

2021

BHSJ

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Introduction: Dyslipidemia is a major health problem in Indonesia which leads to other diseases. Triglycerides (TG) is one of the increased lipid fractions which is related to dyslipidemia. Simvastatin is the main therapy in Indonesia to lower TG levels. The use of virgin coconut oil (VCO) becomes popular as a blood cholesterol-lowering agent even though the effects on TG level remains elusive. Since there is no empirical evidence VCO as a complementary therapy of simvastatin on TG levels, this experimental trial is conducted to determine the effect of simvastatin and VCO combination therapy on blood TG levels in dyslipidemic male white rats.Methods: 42 white rats (Rattus norvegicus) divided into 5 treatment groups and preliminary test of dyslipidemia. The blood was collected intracardially and TG level was measured by using spectrophotometric methods. Independent variables are simvastatin and VCO and combination therapy while the dependent variable is TG levels of white rats. The data was afterwards analyzed using Mann-Whitney U test.Results: The control group’s triglyceride plasma level, receiving standard diet, is 59±13,4 mg/dl. The VCO-only group shows 72±35,4 mg/dl while simvastatin-only group shows 61,9±22,6 mg/dl triglyceride level. Combination therapy of simvastatin and VCO shows 62,3±31,3 mg/dl (p>0,05).Conclusion: There were no significant differences between groups with control. However,the use of VCO with particular dose and duration of therapy, will significantly decrease triglyceride level in the blood as effective as simvastatin. VCO has no efficacy while used as combination therapy of simvastatin.

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“…Based on research by Augus Venty et al Provides the result that administration of Virgin coconut oil (VCO) from the species Cocos nucifera is known to be effective in preventing dyslipidemia in Rattus norvegicus in reducing CT, TG, and LDL levels and increasing HDL levels (p=0.05) compared to the control group with intervention for 28 days. The dose of VCO was 0.8 ml/200 gBB 15 . Based on another study conducted by Feti Fatimah and Barlina Rindengan, it has also been studied that administration of VCO emulsion diets can effectively improve lipid profile levels (p=0.05) compared to the study control and the pure VCO intervention group after seven days of intervention 16 .…”

confidence: 99%

Potensi Jus Kombinasi Daging Kelapa (Cocos nucifera) dan Daging Putih Semangka (Citrullus lanatus) sebagai Modalitas Preventif Dislipidemia

Afifudin,

Fajar,

Budiyanto

et al. 2023

AMNT

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Latar Belakang: Dislipidemia merupakan keadaan dimana kadar biokimia lipid didalam tubuh berada dalam rentang abnormal. Dislipidemia dapat berpotensi untuk menimbulkan penyakit seperti aterosklerosis dan penyakit jantung koroner. Daging buah kelapa serta daging putih buah semangka diketahui memiliki senyawa antioksidan yang dapat mencegah dislipidemia. Tujuan: Penelitian ini bertujuan untuk membuktikan potensi pemberian kombinasi daging buah kelapa dan daging buah semangka dapat menginhibisi parameter metabolik pada kondisi dislipidemia. Metode: Penelitian ini adalah penelitian eksperimental berdesain post-test only with control group design yang melibatkan 5 kelompok dengan 25 ekor tikus Wistar perlakuan dengan induksi dislipidemia dengan menggunakan kuning telur puyuh. Perlakuan dilanjutkan dengan intervensi jus daging kelapa atau jus daging putih semangka atau kombinasi keduanya; dan 1 kelompok kontrol dengan induksi dislipidemia dengan kuning telur puyuh yang dilanjutkan dengan intervensi akuades. Durasi intervensi dilakukan selama 28 hari dengan pengambilan darah dilakukan di hari ke-29. Uji kadar profil lipid dilakukan dengan menggunakan plasma darah. Analisis data diawali dengan uji shapiro-wilk yang dilanjutkan dengan uji one-way ANOVA. Hasil: Tidak ada perbedaan yang signifikan pada hasil LDL, trigliserida, dan kolesterol total antar kelompok (p>0,05) dan perbedaan HDL yang signifikan antar kelompok (p<0,05). Kesimpulan: Intervensi jus daging putih semangka dan daging kelapa secara signifikan mempengaruhi kadar HDL tetapi tidak secara signifikan mempengaruhi tingkat LDL, trigliserida, dan kolesterol total tikus dislipidemia.

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Efek Pemberian Virgin Coconut Oil (Cocos nucifera) terhadap Dislipidemia pada Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diberi Diet Tinggi Kolesterol

Cited by 5 publications

References 15 publications

Effect of Virgin Coconut Oil Administration to Increase HDL, Decrease LDL and IL-6 in Hypercholesterol Male Wistar Rats

Effect of Virgin Coconut Oil Administration to Increase HDL, Decrease LDL and IL-6 in Hypercholesterol Male Wistar Rats

The Effect of Simvastatin and Virgin Coconut Oil (VCO) Combination Therapy as Triglyceride Plasma Lowering Agent in White Dyslipidemic Male Rat (Rattus norvegicus)

Potensi Jus Kombinasi Daging Kelapa (Cocos nucifera) dan Daging Putih Semangka (Citrullus lanatus) sebagai Modalitas Preventif Dislipidemia

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