Efek Sinergis Bahan Aktif Tanaman Obat Berbasiskan Jejaring Dengan Protein Target

Abstract

Medicinal plants contain inherently active ingredients. Such ingredients are beneficial to prevent and cure diseases, as well as to perform specific biological functions. In contrast to synthetic drugs, which is based on one single chemicals, medicinal plants exert their beneficial effects through the additive or synergistic action of several chemical compounds. Those chemical compound act on single or multiple targets (multicomponent therapeutic) associated with a physiological process. Active ingredients combinations show a synergistic effect. This means that the combinational effect of several active ingredients is greater than that of individual one acting separately. A network target can be used to identify synergistic effects of plants active ingredients. The method of NIMS (Network target-based Identification of Multicomponent Synergy) is a computational approach to identify the potential synergistics effect of active ingredients. It also assessess synergistic strength of any active ingradients at the molecular level by synergy scores. We investigate these synergistic on a Jamu formula for diabetes mellitus type 2. The Jamu formula is composed of four medicinal plants, namely Tinospora crispa , Zingiber officinale, Momordica charantia, and Blumea balsamivera. Our work succesfully demonstrates that the highest synergy scores on medicinal plants synergy can be seen in pairs of several active ingredients in Zingiber officinale. On the other hand, the synergy of pairs of active ingredients in Momordica charantia and Zingiber officinale posseses a relatively high score. The same occurs in Tinospora crispa and Zingiber officinale.

Antioxidant Capacity and α-Amilase Inhibition by Avocado (Persea americana Mill) Peel and Red Ginger (Zingiber officinale var. Rubrum) based Functional Drink

“…Apparently, because the two ingredients have the same high effect, a synergistic effect was observed when the two were combined. This is in line with research reported by Syahrir et al [37] which states that the combination between active ingredients can show a synergistic.…”

Gastroprotective effect of Canna edulis Ker. ethanolic extract in piroxicam-induced rats

“…This allegedly happened because of the saturation factor of the extract at specific doses. Several components of active compounds in plants are simultaneously involved in therapy, thus enabling these active compound components to have a synergistic or antagonistic effect (Syahrir et al, 2016). Thus, the synergistic effect that occurs can increase concentration to the saturation point.…”

Short communication: Effects of the various source areas of Indonesian bay leaves (Syzygium polyanthum) on chemical content and antidiabetic activity

“…It was predicted that the SEJ extract contains quercetin and coniferin compounds, the SCJ extract contains quercetin and juncusol compounds, and the SWJ extract, in addition to quercetin, contains retucine. Although all locations were predicted to contain quercetin compounds, which are known to have antidiabetic activity, the level of activity of extracts from each region is different because of the interaction of quersetin compounds with other compounds that can be antagonistic-decreasing activity-or synergistic-strengthening activity (Syahrir 2016).…”