Effect A Glycosidic Flavonol Isolated from Green Grass Jelly (Cyclea Barbata Miers) Leaves

Kusmardiyani, Siti; Insanu, Muhamad; Asyhar, Ma'sum Al

doi:10.1016/j.proche.2014.12.026

Cited by 11 publications

(11 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…revealed that flavonoids contained in the leaves of green grass jelly are a flavonol 3-oglikosida [17]. A previous study by Chen et al revealed that flavonoids in Lonicera japonica could reduce pro-inflammatory cytokines in the wound excision in day 1 and 9 post-creation of the wound [32].…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Effects of Ethanol Cincau (Cyclea Barbata Miers) Leaves Extract on Macrophage Migration on Burn Wound

Riawan

Rini

et al. 2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Macrophages are essential cells in burn wound healing. The primary function of macrophages is phagocytosis of microbes and necrosis tissue. Migration of macrophages into the wound area is affected by interleukin-1 (IL-1). Ethanol extract of Cincau or green grass jelly leaves or Cyclea barbata Miers contains pectin, flavonoids, and alkaloids. These compounds influence the inflammatory process. The purpose of this study was to reveal the effect of ethanol Cincau leaves extract on the expression of IL-1 and the number of macrophages in second degree burn wounds tissue. Methods: This study used 30 rats divided into six groups based on different treatments: NaCl 0.9% (K), silver sulfadiazine/(SSD) (P1), hydrogels (P2), Cincau extract 40% (P3), Cincau extract 50% (P4), and Cincau extract 60% (P5). Treatment was conducted over 4 days. On the 5th day, burn wounds tissues were taken, then immunohistochemistry staining was applied. Results: One-way ANOVA test on the expression of IL-1 showed a difference among groups (p<0.05) and on the number of macrophages (p<0.05). Post hoc tests on the expression of IL-1 showed Cincau extracts 40% and 50% treated-groups significantly differ with the NaCl 0.9% group but not with hydrogel treated group. The similar result showed Cincau extracts 40% and 50% treated-groups significantly differ from the control group but not with SSD and hydrogel groups. Conclusions: It can be concluded that ethanol extract of Cincau leaves can decrease IL-1 expression and increase the number of macrophages which have an important role in inflammation resolution of burn wounds.

show abstract

Section: Discussionmentioning

confidence: 98%

“…This plant is easily cultivated and grows wild [16]. Substances contained in the Cincau are alkaloids, flavonoids, and polysaccharide pectin [15][16][17][18][19]. Alkaloids and flavonoids are antioxidants compounds that function as an immune stimulant to macrophages and scavenger of the free radicals in burns [18,19].…”

Section: Dewi Et Almentioning

confidence: 99%

Effects of Ethanol Cincau (Cyclea Barbata Miers) Leaves Extract on Macrophage Migration on Burn Wound

Riawan

Rini

et al. 2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…One herb that has been shown empirically to have anti-inflammatory properties is Cyclea barbata Miers. C. barbata leaves are often used to treat diarrhea, abdominal pain, fever, inflammation, hypertension, and oral ulceration [4,5].…”

Section: Introductionmentioning

confidence: 99%

Cyclea Barbata Leaf Extract: Lipoxygenase Inhibitory Activity and Phytochemical Screening

2018

View full text Add to dashboard Cite

Objective: The aim of this study was to test the anti-inflammatory activity of methanol, ethyl acetate, and n-hexane Cyclea barbata Miers. leaf extracts using a lipoxygenase inhibition method.Methods: Enzyme activity assay was performed using colorimetric method with lipoxygenase from soybean and linoleic acid as a substrate. Absorbance was measured at 234 nm. The total flavonoid content of the most active extract was determined using a colorimetric method with AlCl 3 and phytochemical screening. Results:The ethyl acetate extract had the highest lipoxygenase inhibiting activity, with an IC 50 value of 0.267 mg/mL. In addition, this extract had a total flavonoid content of 21.62 mgQE/g and contained flavonoids, glycosides, and terpenoids.Conclusion: This finding indicated that C. barbata provides a possible anti-inflammatory effect through the inhibition of lipoxygenase. However, further research is still needed to strengthen this result.

show abstract

“…In Indonesia, grass jelly is known as a traditional functional drink which has specific health benefit [1], [2]. Both Cyclea Barbata Miers and Mesona Palustris Bl, varieties of grass jelly, were commonly used as raw material to make grass jelly [3], [4]. Fig.…”

Section: Introductionmentioning

confidence: 99%

Designing and Experimenting Semi-automatic Green Grass Jelly Squeezer

Iqbal¹,

Ciptaningtyas²

2018

International Journal on Advanced Science, Engineering and Information Technology

View full text Add to dashboard Cite

In Indonesia, green grass jelly is widely known as traditional drink obtained from soaking grass jelly leaves in the water. Nowadays, the production process of grass jelly was conducted manually, which consumes lots of time and energy. Therefore, this research aimed to design a semi-automatic green grass jelly squeezer to accelerate and simplify the production process. Moreover, the squeezer performance and several quality parameters of the jelly produced by the squeezer were examined. The designing process of green grass jelly squeezer was conducted through several stages. Those were concept design, manufacture and assembled stage, performance test, modification, and examination. The result shows that the most efficient production process was at 6000 RPM and the digital value of 540. The measurements of Soluble Solid (SS) and gel strength show that jelly produced by the squeezer has higher SS and F max than the control. The sensory evaluation shows jelly with the digital value of 520 get the best consumer acceptance, which means the consumer prefer neither too dense nor too solid green grass jelly. The result shows that no effect of digital value and RPM on syneresis examination.

show abstract

Effect A Glycosidic Flavonol Isolated from Green Grass Jelly (Cyclea Barbata Miers) Leaves

Cited by 11 publications

References 1 publication

Effects of Ethanol Cincau (Cyclea Barbata Miers) Leaves Extract on Macrophage Migration on Burn Wound

Effects of Ethanol Cincau (Cyclea Barbata Miers) Leaves Extract on Macrophage Migration on Burn Wound

Cyclea Barbata Leaf Extract: Lipoxygenase Inhibitory Activity and Phytochemical Screening

Designing and Experimenting Semi-automatic Green Grass Jelly Squeezer

Contact Info

Product

Resources

About