Effect and safety of paroxetine combined with zolpidem in treatment of primary insomnia

Yu, Zhenghe; Xu, Xiaoru; Wang, S D; Song, Meijuan; Liu, Y; Yin, You; Mao, Huiwu; Tang, Guangzheng

doi:10.1007/s11325-017-1462-0

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…The secondary outcomes will include: (I) sleep onset latency (in min) and sleep efficiency (%). Sleep efficiency is defined as the total sleep time, divided by the total recording time; (II) Insomnia Severity Index [37]; (III) Quality of Life Scale (SF-36) [38]; and (IV) adverse events measured by the Treatment Emergent Symptom Scale (TESS) [39] or the incidence of adverse events.…”

Section: Secondary Outcomesmentioning

confidence: 99%

Acupuncture methods for insomnia disorder in the elderly: protocol for a systematic review and network meta-analysis

Dong

Zhou

et al. 2023

Syst Rev

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Background Insomnia disorder remains one of the most common sleep disorders in the elderly, with high prevalence and substantial consequences for patients’ general health. Despite that increasing clinical trials have indicated that acupuncture seems to be effective for insomnia disorder in the elderly, comparative efficacy and safety of different acupuncture methods for elderly individuals with insomnia disorder has been unclear. Therefore, this protocol outlined a plan to evaluate and rank the efficacy and safety of various acupuncture approaches for insomnia disorder in the elderly. Methods A systematic search of 8 bibliographic databases will be conducted from their inception to 18 June 2023, including Cochrane Library, MEDLINE (via PubMed), Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database, and Chinese Biomedical Literature Database (CBM). Randomized controlled trials investigating acupuncture methods for insomnia disorder in the elderly, published in English or Chinese will be included. The primary outcome is sleep quality measured by the Pittsburgh Sleep Quality Index (PSQI). Two reviewers will independently perform study selection, data extraction and risk assessment of bias. The quality of included literatures will be appraised using Cochrane risk-of-bias tool (ROB 2.0). ADDIS (Aggregate Data Drug Information System) V.1.16.8 will be used to conduct Bayesian network meta-analysis. The quality of evidence will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation System (GRADE). Discussion In this study, the results will provide credible evidence to assess the efficacy and safety of acupuncture therapies for elderly patients with insomnia disorder, assisting patients, physicians and clinical research investigators to select the most appropriate acupuncture method. Systematic review registration The protocol has been registered at OSF (https://osf.io/3kjpq/) with a registration number https://doi.org/10.17605/OSF.IO/3KJPQ.

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Section: Secondary Outcomesmentioning

confidence: 99%

Acupuncture methods for insomnia disorder in the elderly: protocol for a systematic review and network meta-analysis

Dong

Zhou

et al. 2023

Syst Rev

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“…Insomnia is a well‐known risk factor for many of diseases, including diabetes (Macêdo, Neves, Poyares, & da Mota Gomes, ), cardiovascular diseases (Leach & Page, ), decreased function of the immune system (Ho et al, ), and a wide range of psychiatric disorders (Chu et al, ; Ji et al, ; Vincent, Walsh, & Chiang, ; Yu et al, ).…”

Section: Introductionmentioning

confidence: 99%

Aloysia citriodora Palau (lemon verbena) for insomnia patients: A randomized, double‐blind, placebo‐controlled clinical trial of efficacy and safety

Afrasiabian

Ardakani

Rahmani

et al. 2018

Phytotherapy Research

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Aloysia citriodora (A. citriodora) has a long history of traditional use for sedation and treatment of insomnia in different societies. This study was carried out to assess the efficacy of A. citriodora in patients with insomnia. One hundred patients were randomly divided into two groups of A. citriodora (total essential oil 1.66 mg/10 ml and total amount of flavonoid in terms of quercetin 3.22 mg/10 ml of the syrup) and placebo. They were advised to use 10 cc of the syrups; an hour before the bedtime for a period of 4 weeks. Participants were assessed using Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) questionnaires at the baseline and then 2 and 4 weeks after the enrollment. Mean scores of global PSQI and its four components including sleep latency, habitual sleep efficiency, daytime dysfunction, and subjective sleep quality and also ISI score in the A. citriodora group improved significantly after 4 weeks of treatment when compared with the placebo group (p < 0.001, for all of them). Also, improvement of global score of PSQI and ISI was observed in the intervention group as compared with the placebo group, 2 weeks after the enrollment (p < 0.001). The results of this study showed that oral intake of A. citriodora can be suggested as a complementary treatment for patients with insomnia.

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Pharmacologic Treatment of Insomnia in Children and Adolescents with Chronic Pain Conditions

González-Cárdenas

Constantin

Somaini

et al. 2019

Curr Anesthesiol Rep

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Effect and safety of paroxetine combined with zolpidem in treatment of primary insomnia

Abstract: Eight weeks of the zolpidem combined with paroxetine treatment to patients with primary insomnia is more effective than zolpidem treatment only in sleep maintenance and early morning awakenings.

Cited by 4 publications

References 16 publications

Acupuncture methods for insomnia disorder in the elderly: protocol for a systematic review and network meta-analysis

Acupuncture methods for insomnia disorder in the elderly: protocol for a systematic review and network meta-analysis

Aloysia citriodora Palau (lemon verbena) for insomnia patients: A randomized, double‐blind, placebo‐controlled clinical trial of efficacy and safety

Pharmacologic Treatment of Insomnia in Children and Adolescents with Chronic Pain Conditions

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