Effect of 0.25 ppm Ozone exposure on pulmonary damage induced by bleomycin

Oyarzún, M; Dussaubat, Nelson; González, Sergio

doi:10.4067/s0716-97602005000400007

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…Using an asthmatic phenotype modeled by allergic sensitization of the respiratory tract, effects of O 3 on pulmonary function have been found to be augmented by allergic sensitization in infant rhesus monkeys (Fanucchi et al 2006; Joad et al 2006; Schelegle et al 2003), mice (Funabashi et al 2004), and rats (Wagner et al 2007). In addition, in a bleomycin-induced pulmonary fibrosis rat model, exposure to O 3 increased pulmonary inflammation and fibrosis, along with the frequency of bronchopneumonia (Oyarzún et al 2005). Thus, short-term O 3 exposure may also enhance damage in a previously injured lung.…”

Section: Resultsmentioning

confidence: 99%

Evaluating Potential Response-Modifying Factors for Associations between Ozone and Health Outcomes: A Weight-of-Evidence Approach

Vinikoor-Imler

Owens

Nichols

et al. 2014

Environ Health Perspect

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Background: Epidemiologic and experimental studies have reported a variety of health effects in response to ozone (O3) exposure, and some have indicated that certain populations may be at increased or decreased risk of O3-related health effects.Objectives: We sought to identify potential response-modifying factors to determine whether specific groups of the population or life stages are at increased or decreased risk of O3-related health effects using a weight-of-evidence approach.Methods: Epidemiologic, experimental, and exposure science studies of potential factors that may modify the relationship between O3 and health effects were identified in U.S. Environmental Protection Agency’s 2013 Integrated Science Assessment for Ozone and Related Photochemical Oxidants. Scientific evidence from studies that examined factors that may influence risk were integrated across disciplines to evaluate consistency, coherence, and biological plausibility of effects. The factors identified were then classified using a weight-of-evidence approach to conclude whether a specific factor modified the response of a population or life stage, resulting in an increased or decreased risk of O3-related health effects.Discussion: We found “adequate” evidence that populations with certain genotypes, preexisting asthma, or reduced intake of certain nutrients, as well as different life stages or outdoor workers, are at increased risk of O3-related health effects. In addition, we identified other factors (i.e., sex, socioeconomic status, and obesity) for which there was “suggestive” evidence that they may increase the risk of O3-related health effects.Conclusions: Using a weight-of-evidence approach, we identified a diverse group of factors that should be considered when characterizing the overall risk of health effects associated with exposures to ambient O3.Citation: Vinikoor-Imler LC, Owens EO, Nichols JL, Ross M, Brown JS, Sacks JD. 2014. Evaluating potential response-modifying factors for associations between ozone and health outcomes: a weight-of-evidence approach. Environ Health Perspect 122:1166–1176; http://dx.doi.org/10.1289/ehp.1307541

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Section: Resultsmentioning

confidence: 99%

Evaluating Potential Response-Modifying Factors for Associations between Ozone and Health Outcomes: A Weight-of-Evidence Approach

Vinikoor-Imler

Owens

Nichols

et al. 2014

Environ Health Perspect

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“…Ozone has been also shown to have a strong killing effect on various bacteria and viruses and many other effects such as modulating Ca 2+ concentration in cells, enhancing the immune response, as well as the increase of oxygenation in the most poorly oxygenated tissue in patients with ischemic disorders. However, ozone was also previously reported to induce lung injury [25][26][27] . In our study, most observations were made within 2 h; it will remain to be explored whether or not the short-term use of ozone-containing HOS will further exaggerate lung injury induced by oleic acid with extended observation.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effect of Hyperoxygenated Solution on Acute Lung Injury Induced by Oleic Acid

Li²,

Feng³

et al. 2008

Eur Surg Res

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Background/Aims: Hyperoxygenated solution (HOS) has been shown to protect the myocardium, spinal cord and brain from ischemic injury. In this study, we evaluated the effect of HOS on acute lung injury (ALI) induced by oleic acid in rabbits. Methods: 24 rabbits were randomized into four groups: control (C), oleic acid (OA), inhaled oxygen (OX), and HOS treatment (HOS). The ALI model was produced by administrating oleic acid intravenously. Half an hour after oleic acid infusion, animals received inhaled oxygen at 30% FiO₂ or 20 ml/kg HOS intravenously. Various parameters were measured during the 2 h after oleic acid treatment. Results: After treatment with oleic acid, mean arterial pressure and PaO₂ decreased significantly compared to group C (p < 0.01), while lung/body ratio, lung water content, and the levels of myeloperoxidase (MPO) and TNF-α in the serum and BALF increased significantly (p < 0.01). Histologically, interstitial edema, alveoli exudation and massive inflammatory cell infiltration were observed in the lung. However, when treated with 20 ml/kg HOS, PaO₂ significantly increased compared to group OA (p < 0.05). The MPO and TNF-α levels in the serum and BALF were decreased (p < 0.01), pulmonary edema was reduced (p < 0.01). Improved pathological manifestations were observed. Conclusion: HOS at 20 ml/kg has therapeutic effects to ameliorate the biological and morphological changes to the lung induced by oleic acid. HOS is a safe, simple and effective measure to protect animals from ALI.

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“…El estudio fue realizado por el patólogo (SGB), sin conocer el tratamiento recibido por cada especimen. El grado de inflamación fue evaluado con puntaje de 0 a 4 (0: ausente, 1: leve, 2: moderada, 3: intensa y 4: muy intensa) 22 . La presencia de macrófagos se evaluó con puntaje de 0 a 3 (0: ausente, 1: escasa, 2: moderada y 3: abundante).…”

Section: Materials Y Métodosunclassified

“…La presencia de macrófagos se evaluó con puntaje de 0 a 3 (0: ausente, 1: escasa, 2: moderada y 3: abundante). El grado de fibrosis se evaluó con la tinción tricrómica de Masson utilizando un puntaje de 0 a 3 (0: ausente, 1: escasa, 2: moderada y 3: intensa) 22 .…”

Section: Materials Y Métodosunclassified

Efecto del sulfato de cobre en el daño pulmonar inducido por la exposición crónica intermitente a ozono

et al. 2017

Rev. méd. Chile

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Effect of copper sulphate on the lung damage induced by chronic intermittent exposure to ozone count, proteins, GGT and AP in BALF (p < 0.05). Foamy and pigmented alveolar macrophages were detected in all lungs of these animals (p < 0.001). Conclusions: Intratracheal instillation of a single dose of CuSO 4 in rats previously subjected to a chronic and intermittent exposure to ozone induces a neutrophil pulmonary inflammatory response and cytoplasmic damage in macrophages. (Rev Med Chile 2017; 145: 9-16)

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Effect of 0.25 ppm Ozone exposure on pulmonary damage induced by bleomycin

Cited by 5 publications

References 13 publications

Evaluating Potential Response-Modifying Factors for Associations between Ozone and Health Outcomes: A Weight-of-Evidence Approach

Evaluating Potential Response-Modifying Factors for Associations between Ozone and Health Outcomes: A Weight-of-Evidence Approach

Therapeutic Effect of Hyperoxygenated Solution on Acute Lung Injury Induced by Oleic Acid

Efecto del sulfato de cobre en el daño pulmonar inducido por la exposición crónica intermitente a ozono

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