Effect of 10% dietary protein intake on whole body protein kinetics in type 2 diabetic adults

Integrated Remodeling of Gut–Liver Metabolism Induced by Moderate Protein Restriction Contributes to Improvement of Insulin Sensitivity

“…PR has been well shown to extend lifespan and ameliorate age‐related metabolic diseases, in particular, insulin resistance . Recently, accumulating evidences demonstrated that the restriction of specific individual EAA, such as leucine, methionine, and tryptophan, exerts the beneficial effect of PR to affect the onset of insulin resistance, obesity and other age‐related diseases .…”

“…Dietary protein restriction (PR), as a feasible dietary intervention, has been shown to extend lifespan, improve human health, especially insulin sensitivity through nutrient sensing pathways to fine tune the metabolic responses in a conserved manner . Dietary protein is digested into small peptides and free amino acids (AA), and undergoes a critical metabolism in enterocytes, which reconstitutes absorbed AA profile .…”

The Effects of Different Quantities and Qualities of Protein Intake in People with Diabetes Mellitus

“…The usual and general recommendation of a minimum intake of 0.8 g/kg bodyweight per day or about 10% of E% is based on studies of nitrogen balance in healthy subjects [35,36]. The analysis of currently available studies shows that there are very limited data on protein intakes of less than 15% of E%, corresponding to about 1 g/kg body weight per day and a short study with 10% of E% as protein indicated that there can be an increased risk of sarcopenia in older subjects with T2D [37]. There is only one study which investigated a higher protein intake over two years in 419 people with T2D [38].…”

“…There is also a lack of randomized studies with regard to lower protein intake. Geriatric experts of the PROT-AGE group recommend higher protein intakes to reduce the risk of frailty and sarcopenia in the older population which often applies to people with T2D [27,37]. Therefore, a range of 15% to 20% of E% as protein intake appears to be reasonable during the long term.…”

Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus

“…Eiweiß wird als Lieferant der Aminosäuren in einer Mindestmenge von etwa 0,8 g/kg Körpergewicht oder 10 E% benötigt, um eine Mangelernährung und Sarkopenie zu vermeiden. Die untere Grenze von 0,8 g/kg/Tag kann für ältere Menschen unzurei-chend sein wegen einer abnehmenden Effizienz der Proteinsynthese [143], weshalb eine höhere Eiweißzufuhr von mindestens 1 g/kg KG/Tag empfohlen wird [144].…”