Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women

Abstract

Background: Evidences have showed that the incidence of arterial hypertension is greater in postmenopausal women as compared to premenopausal. Physical inactivity has been implicated as a major contributor to weight gain and abdominal obesity in postmenopausal women and the incidence of cardiovascular disease increases dramatically after menopause. Additionally, more women than men die each year of coronary heart disease and are twice as likely as men to die within the first year after a heart attack. A healthy lifestyle has been strongly associated with the regular physical activity and evidences have shown that physically active subjects have more longevity with reduction of morbidity and mortality. Nitric oxide (NO) produced by endothelial cells has been implicated in this beneficial effect with improvement of vascular relaxing and reduction in blood pressure in both laboratory animals and human. Although the effect of exercise training in the human cardiovascular system has been largely studied, the majority of these studies were predominantly conducted in men or young volunteers. Therefore, the aim of this work was to investigate the effects of 6 months of dynamic exercise training (ET) on blood pressure and plasma nitrate/nitrite concentration (NOx -) in hypertensive postmenopausal women.

Influence of eNOS gene polymorphism on cardiometabolic parameters in response to physical training in postmenopausal women

“…However, the data for the three most studied eNOS polymorphisms, T-786C, G894T and Intron 4b/a, are not yet conclusive (12). Evidence has shown that physically active subjects have more longevity with less morbidity and mortality (23,24). Confirming previous studies, in the present investigation, we observed that a 8-week exercise training was effective in lowering both systolic and diastolic blood pressure in postmenopausal women.…”

Prevalência de síndrome metabólica e fatores associados em adolescentes de 11 a 17 anos

“…If on the one hand, a low level of physical activity is an important risk factor for body weight gain and the subsequent development of obesity, on the other hand physical exercise seems to affect MS components without necessarily reducing body fat 26 . Although high-intensity exercise programs can induce positive changes in HDL-c concentrations, the same does not appear to occur when the main purpose is to reduce body fat, since highintensity exercises cannot be sustained for prolonged periods.…”

Indicadores Indicadores cardiovasculares em repouso e durante um teste incremental em jovens. DOI: 10.5007/1980-0037.2012v14n1p32

“…Zaros et al, 15 after 24 weeks of aerobic training in hypertensive women, identified an increase in the values of circulating nitrite and nitrate (subproducts of the use of nitric oxide) 15 . The aforementioned mechanisms could help to explain the maximum greater consumption of oxygen observed for the normotensive subjects, as physical aptitude is a strong indicator of the practice of physical activities and many of the benefits of practicing physical activities are measured by the increments on physical aptitude.…”