Effect of a Novel Stent on Re-Endothelialization, Platelet Adhesion, and Neointimal Formation

Tang, Hanfei; Wang, Qi; Wang, Xiaobo; Zhou, Jianping; Zhu, Ming; Qiao, Tiankui; Liu, Changjian; Mao, Chun; Zhou, Min

doi:10.5551/jat.31062

Cited by 15 publications

(6 citation statements)

References 35 publications

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“…This computer simulation finding is in good agreement with these previous biological, experimental findings. Detailed clinical observations with the use of OCT in patients with very late stent thrombosis revealed the presence of in-stent neointimal rupture in approximately 70% of patients [ 46 ]. The rate of neointimal rupture was higher than the prevalence of stent malapposition of 42% [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…Detailed clinical observations with the use of OCT in patients with very late stent thrombosis revealed the presence of in-stent neointimal rupture in approximately 70% of patients [ 46 ]. The rate of neointimal rupture was higher than the prevalence of stent malapposition of 42% [ 46 ]. The contributing role of platelets in neointimal plaque formation remains to be elucidated [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

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Computer Simulation of Platelet Adhesion around Stent Struts in the Presence and Absence of Tissue Defects around Them

Kawamura

Tamura

Goto

et al. 2021

Journal of Interventional Cardiology

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Aim. To predict platelet accumulation around stent struts in the presence or absence of tissue defects around them. Methods. Computer simulations were performed using virtual platelets implementing the function of the three membrane proteins: glycoprotein (GP) Ibα, GPIIb/IIIa, and GPVI. These platelets were perfused around the stent struts implanted into the vessel wall in the presence or absence of tissue defects around them using within the simulation platform. The number of platelets that adhered around stent struts was calculated by solving the blood flow using Navier–Stokes equation along with the adhesion of membrane protein modeled within the platform. Results. Platelet accumulation around stent struts occurred mostly at the downstream region of the stent strut array. The majority of platelets adhered at the downstream of the first bend regardless of the tissue defect status. Platelet adhesion around stent struts occurred more rapidly in the presence of tissue defects. Conclusion. Computer simulation using virtual platelets suggested a higher rate of platelet adhesion in the presence of tissue defects around stent struts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Computer Simulation of Platelet Adhesion around Stent Struts in the Presence and Absence of Tissue Defects around Them

Kawamura

Tamura

Goto

et al. 2021

Journal of Interventional Cardiology

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“…For all regenerative purposes and translational intents, current and future endeavors utilizing cell-capture mechanism may continue in three directions: 1) combining cell-capture molecules with other prohealing/proregenerative molecules; ( Chen et al, 2015 ; Zhang et al, 2015 ; Wang et al, 2020a ; Yang et al, 2020a ) 2) using more selective or specific molecules to recognize a subset of EPCs; ( Hirase, 2016 ; Tang et al, 2016 ) 3) exploiting EPC-derived secretomes such as those in the form of exosomes ( Zeng et al, 2021 ).…”

Section: Novel Developments and Challenges In Stentsmentioning

confidence: 99%

Applying Principles of Regenerative Medicine to Vascular Stent Development

Parthiban

Rafuse

Johnson

et al. 2022

Front. Bioeng. Biotechnol.

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Stents are a widely-used device to treat a variety of cardiovascular diseases. The purpose of this review is to explore the application of regenerative medicine principles into current and future stent designs. This review will cover regeneration-relevant approaches emerging in the current research landscape of stent technology. Regenerative stent technologies include surface engineering of stents with cell secretomes, cell-capture coatings, mimics of endothelial products, surface topography, endothelial growth factors or cell-adhesive peptides, as well as design of bioresorable materials for temporary stent support. These technologies are comparatively analyzed in terms of their regenerative effects, therapeutic effects and challenges faced; their benefits and risks are weighed up for suggestions about future stent developments. This review highlights two unique regenerative features of stent technologies: selective regeneration, which is to selectively grow endothelial cells on a stent but inhibit the proliferation and migration of smooth muscle cells, and stent-assisted regeneration of ischemic tissue injury.

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“…Among EPC subsets, outgrowth endothelial cells (OECs) preferentially express VE‐cadherin, and exhibit greater vasculogenic activity with more rapid proliferation and more active migration . Therefore capturing OECs more selectively with anti‐VE‐cadherin antibody could be responsible for a more efficient re‐endothelialization and anti‐thrombogenicity of anti‐VE‐cadherin antibody‐coated stents in animal models …”

Section: Strategies To Promote Re‐endothelialization After Stent Implmentioning

confidence: 99%

The effects of stenting on coronary endothelium from a molecular biological view: Time for improvement?

Cornelissen

Vogt

2018

J Cellular Molecular Medi

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Coronary artery stenting following balloon angioplasty represents the gold standard in revascularization of coronary artery stenoses. However, stent deployment as well as percutaneous transluminal coronary angioplasty (PTCA) alone causes severe injury of vascular endothelium. The damaged endothelium is intrinsically repaired by locally derived endothelial cells and by circulating endothelial progenitor cells from the blood, leading to re‐population of the denuded regions within several weeks to months. However, the process of re‐endothelialization is often incomplete or dysfunctional, promoting in‐stent thrombosis and restenosis. The molecular and biomechanical mechanisms that influence the process of re‐endothelialization in stented segments are incompletely understood. Once the endothelium is restored, endothelial function might still be impaired. Several strategies have been followed to improve endothelial function after coronary stenting. In this review, the effects of stenting on coronary endothelium are outlined and current and future strategies to improve endothelial function after stent deployment are discussed.

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Effect of a Novel Stent on Re-Endothelialization, Platelet Adhesion, and Neointimal Formation

Cited by 15 publications

References 35 publications

Computer Simulation of Platelet Adhesion around Stent Struts in the Presence and Absence of Tissue Defects around Them

Computer Simulation of Platelet Adhesion around Stent Struts in the Presence and Absence of Tissue Defects around Them

Applying Principles of Regenerative Medicine to Vascular Stent Development

The effects of stenting on coronary endothelium from a molecular biological view: Time for improvement?

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