Effect of Acute Aerobic Exercise on Vaccine Efficacy in Older Adults

Ranadive, Sushant M.; Cook, Marc D.; Kappus, Rebecca M.; Yan, Huimin; Lane, Abbi D.; Woods, Jeffery A.; Wilund, Kenneth R.; Iwamoto, Gary A.; Vanar, Vishwas; Tandon, R; Fernhall, Bo

doi:10.1249/mss.0b013e3182a75ff2

Cited by 41 publications

(43 citation statements)

References 24 publications

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“…Long et al [15] examined whether acute moderate exercise can improve immune responses to pneumonia and half dose influenza immunization and found no enhanced responses to either of the vaccines. Ranadive et al [14] also reported no difference in antibody responses in older men. However, results were not uniform in men and women.…”

Section: Moderate Aerobic Exercisementioning

confidence: 93%

“…However, contrary findings to this also exist. Ranadive et al [14] studied the effects of acute moderate exercise on influenza vaccine effectiveness, suggesting that acute moderate exercise does not enhance the vaccine efficacy in older men. Similarly, Long et al [15] also reported that moderate intensity brisk walking has no effect on antibody responses to both influenza and pneumonia immunization.…”

Section: Introductionmentioning

confidence: 99%

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Benefits of Exercise on Influenza or Pneumonia in Older Adults: A Systematic Review

Song

Ren

Sun

et al. 2020

IJERPH

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A coronavirus pandemic has recently become one of the greatest threats the world is facing. Older adults are under a high risk of infection because of weaker immune systems. Therefore, the purpose of this review is to summarize the recent scientific evidence that outlines the effects of exercise on influenza or pneumonia in older adults. An electronic literature search was conducted using the WEB OF SCIENCE, SCIENCEDIRECT and GOOGLE SCHOLAR databases using the following keywords, "Exercise," "Older adult," "Influenza," and "Pneumonia." Any randomized control trials, cross-sectional and observational studies that related to this topic were all included. Twenty studies met the eligibility criteria for this review. Thirteen randomized control trials investigated the effects of exercise on the immune responses to influenza or pneumonia vaccination: seven trials employed moderate aerobic exercise, three employed resistance exercise, and the remaining three used Asian martial arts or special home-based exercises. Five cross-sectional and two observational studies examined the associations between exercise/physical condition and influenza/pneumonia. Most of the current studies suggested that prolonged moderate aerobic exercise may help to reduce the risk of influenza-related infection and improve the immune responses to influenza or pneumonia vaccination in older adults. In addition, training in traditional Asian martial arts was also found to be beneficial. Future research should focus on the different effects of moderate and vigorous exercise on influenza-related diseases.

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Section: Moderate Aerobic Exercisementioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Benefits of Exercise on Influenza or Pneumonia in Older Adults: A Systematic Review

Song

Ren

Sun

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…The acute effects of various types of exercise has also been investigated in a number of studies (Edwards et al, 2006(Edwards et al, , 2008Campbell et al, 2010;Edwards et al, 2010Edwards et al, , 2012Long et al, 2012;Ranadive et al, 2014). Generally, these studies have been conducted with younger rather than older subjects and in most of these cases no benefits are observed.…”

Section: Moderate Exercisementioning

confidence: 99%

Exercise, Immunity, and Illness

Jones

Davison

2019

Muscle and Exercise Physiology

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“…However, it has been shown that influenza vaccination did not lead to decreased titers when conducted immediately after physical activity and that acute exercise even increased antibody responses in pneumococcal vaccination [138–141]. In another study in elite athletes, titers after hepatitis B vaccination were identical to the general population [142].…”

Section: Timing Of Vaccinationsmentioning

confidence: 99%

“…influenza), there is no major medical problem with vaccinating shortly after a competition to make the period of time to the next competition as long as possible. Acute exercise might even act as a weak adjuvant, increasing antibody responses slightly in some individuals [138, 139, 141, 143]. In contrast, the pain reaction following the vaccination was clearly diminished when vaccinating 6 h after activity compared with vaccination immediately or 24–48 h after activity [143].…”

Section: Timing Of Vaccinationsmentioning

confidence: 99%

Vaccination in Elite Athletes

Гартнер

Meyer

2014

Sports Med

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Public health vaccination guidelines cannot be easily transferred to elite athletes. An enhanced benefit from preventing even mild diseases is obvious but stronger interference from otherwise minor side effects has to be considered as well. Thus, special vaccination guidelines for adult elite athletes are required. In most of them, protection should be strived for against tetanus, diphtheria, pertussis, influenza, hepatitis A, hepatitis B, measles, mumps and varicella. When living or traveling to endemic areas, the athletes should be immune against tick-borne encephalitis, yellow fever, Japanese encephalitis, poliomyelitis, typhoid fever, and meningococcal disease. Vaccination against pneumococci and Haemophilus influenzae type b is only relevant in athletes with certain underlying disorders. Rubella and papillomavirus vaccination might be considered after an individual risk–benefit analysis. Other vaccinations such as cholera, rabies, herpes zoster, and Bacille Calmette–Guérin (BCG) cannot be universally recommended for athletes at present. Only for a very few diseases, a determination of antibody titers is reasonable to avoid unnecessary vaccinations or to control efficacy of an individual’s vaccination (especially for measles, mumps, rubella, varicella, hepatitis B and, partly, hepatitis A). Vaccinations should be scheduled in a way that possible side effects are least likely to occur in periods of competition. Typically, vaccinations are well tolerated by elite athletes, and resulting antibody titers are not different from the general population. Side effects might be reduced by an optimal selection of vaccines and an appropriate technique of administration. Very few discipline-specific considerations apply to an athlete’s vaccination schedule mainly from the competition and training pattern as well as from the typical geographical distribution of competitive sites.

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Effect of Acute Aerobic Exercise on Vaccine Efficacy in Older Adults

Abstract: Acute moderate aerobic exercise was not immunostimulatory in healthy older men but may serve as a vaccine adjuvant in older women.

Cited by 41 publications

References 24 publications

Benefits of Exercise on Influenza or Pneumonia in Older Adults: A Systematic Review

Benefits of Exercise on Influenza or Pneumonia in Older Adults: A Systematic Review

Exercise, Immunity, and Illness

Vaccination in Elite Athletes

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