Effect of Acute L-Tryptophan Exposure on the Brain Serotonergic System and Behavior in the Male Medaka

Koutoku, Tomoyuki; Zhang, Rong; Tachibana, Tetsuya; Oshima, Yuji; Furuse, Mitsuhiro

doi:10.2108/zsj.20.121

Cited by 11 publications

(1 citation statement)

References 12 publications

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“…The monoamine 5-HT suppresses aggressive behavior (Adams et al, 1996), whereas DA stimulates it (Munro, 1986;Tiersch and Griffith, 1988). In addition, exposure to tryptophan, a precursor of 5-HT, stimulates serotonergic neurons and increases locomotor activity in medaka (Koutoku et al, 2003). In our previous studies, TBT affected sexual and nonsexual behavior of male medaka (Nakayama et al, 2004a,b), and these behavioral abnormalities might be associated with alterations of monoamine concentrations in the brain.…”

Section: Discussionmentioning

confidence: 78%

Alteration of monoamine concentrations in the brain of medaka, Oryzias latipes, exposed to tributyltin

Nakayama¹,

Oshima²,

Tachibana³

et al. 2007

Environmental Toxicology

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ABSTRACT:We measured the concentrations of monoamines in the brain of Japanese medaka, Oryzias latipes, exposed to tributyltin (TBT). Fish were exposed to 0, 1, 5, 25, or 125 g g À1 of TBT via the diet for 21 days. After the administration period, six males and six females in each treatment group were dissected and their brains were collected. The following monoamines were analyzed: dopamine (DA), norepinephrine (NE), epinephrine (E), and 5-hydroxytryptamine (5-HT). The metabolites of DA, 3,4-dihydroxyphenylacetic acid and homovanilic acid, and the metabolite of 5-HT, 5-hydroxyindolacetic acid were also analyzed. The concentration of DA in the brain of male medaka and the concentrations of 5-HT and NE in the female brains were significantly decreased by exposure to 125 g TBT g À1. The concentrations of 5-HT and NE in males and of DA in females were slightly decreased by 125 g g À1 of TBT, although the differences were not statistically significant. The present study demonstrates that TBT alters monoamine concentrations in the brain of medaka. # 2007 Wiley Periodicals, Inc. Environ Toxicol 22: 53-57, 2007.

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Section: Discussionmentioning

confidence: 78%

Alteration of monoamine concentrations in the brain of medaka, Oryzias latipes, exposed to tributyltin

Nakayama¹,

Oshima²,

Tachibana³

et al. 2007

Environmental Toxicology

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Zebrafish Biogenic Amine Transporters and Behavior in Novel Environments: Targets of Reuptake Inhibitors and Pesticide Action as Tools for Neurotoxicology Research

Gould

2010

Neuromethods

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Comparison of Toxicities of Metal Pyrithiones Including Their Degradation Compounds and Organotin Antifouling Biocides to the Japanese Killifish Oryzias latipes

Ohji

Harino

2017

Arch Environ Contam Toxicol

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Japanese killifish Oryzias latipes were exposed to three levels (0, 1, and 10 µg l) of copper pyrithione (CuPT), zinc pyrithione (ZnPT), six of their degradation products, and the organotin compounds tributyltin (TBT) and triphenyltin (TPT) for 48 h at 20 °C. All individual fish exposed to 1 and 10 µg l of CuPT or 10 µg l of ZnPT were dead within 12 h, respectively, and at 24 h the survival rate of the fish exposed to 1 µg l of ZnPT was 50%. All fish exposed to 10 µg l of ZnPT showed morphological abnormalities in the form of vertebral deformity. None of the fish exposed to six of the degradation products of PTs, TBT, and TPT died during a 48-h exposure period, but various biological effects were observed in the fish exposed to these chemicals: abnormalities of respiration and swimming behavior, and decreased hatchability. Our findings suggest that O. latipes has a higher ecological risk of CuPT and ZnPT exposure than of TBT and TPT exposure during their life history. Because these antifouling biocides have been used in both freshwater and marine environments, our results highlight these biocides' deleterious effects on the freshwater fish as well as marine fish, and they indicate freshwater and marine pollution.

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Effect of Acute L-Tryptophan Exposure on the Brain Serotonergic System and Behavior in the Male Medaka

Cited by 11 publications

References 12 publications

Alteration of monoamine concentrations in the brain of medaka, Oryzias latipes, exposed to tributyltin

Alteration of monoamine concentrations in the brain of medaka, Oryzias latipes, exposed to tributyltin

Zebrafish Biogenic Amine Transporters and Behavior in Novel Environments: Targets of Reuptake Inhibitors and Pesticide Action as Tools for Neurotoxicology Research

Comparison of Toxicities of Metal Pyrithiones Including Their Degradation Compounds and Organotin Antifouling Biocides to the Japanese Killifish Oryzias latipes

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