Effect of Additives on the Physicochemical and Drug Release Properties of Pioglitazone Hydrochloride Spherical Agglomerates

Patil, Sachinkumar; Pawar, Atmaram; Kumar, Sunit

doi:10.4314/tjpr.v11i1.3

Cited by 12 publications

(6 citation statements)

References 13 publications

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“…Mean particle size of linezolid was determined by randomly counting average diameter of 100 particles with an optical microscope (microscopy method). It was found that particle size of plane crystals and crystals with additives was increased than original crystals may be due to particle crystallisation is shown in table 4 [23]. The presence of DCM at the surface of the growing agglomerate, the agitation force, winter particulate attraction, and polymers (Talc, PEG and HPMC) influenced the size of agglomerates, as reported in earlier studies [16].…”

Section: Resultssupporting

confidence: 58%

Improvement of Micromeritic, Compressibility and Solubility Characteristics of Linezolid by Crystallo-Co-Agglomeration Technique

Kadam

Patil

2017

Int J App Pharm

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Objective: The purpose of current study was to improve physicochemical properties such as micrometric, compressibility and solubility of linezolid (LNZ) by preparing crystallo-co-agglomerates (CCA) in the presence of polymer for the enhancement of overall physicochemical performance. Methods:The process of agglomeration involves the use of dichloromethane (DCM) as a good solvent and chloroform as bridging liquid were used to prepare agglomerates. Agglomerates were characterised in the solid state using several techniques such as Scanning electronic microscopy(SEM), Fourier transformation infrared spectroscopy (FTIR), X-ray powder diffraction analysis (XRPD) The agglomerates obtained were evaluated for micrometric, mechanical, deformation, compressibility and drug release properties.Results: It was found that micrometric properties and dissolution characteristics of agglomerates were significantly improved than that of pure linezolid. Solubility was found to be increased than pure linezolid. The solubility of crystallo co-agglomerates was found an increase in 5 fold 3 fold and 3.7 fold for PVPK30 (0.5%), PVPK30 (0.25%) and PVPK30 (0.75%) respectively. The angle of repose for all batches was found between 22 ° to 30 °Carrs index was between 12.27±0.6 to 18.73±0.4 and Hausners ratio Near to 1, indicated good flow ability of agglomerates. The time required for drug release over a period of 60 min, is as LA1>LA2>LA3. LA3 shows fast drug release than LA1 and LA2, due to solubilization of drug due to more concentration of PVPK30 and less concentration of talc.Conclusion: Based on the above results, it was revealed that CCA of linezolid prepared with DCM and HPMC (Hydroxypropyl methyl cellulose)/PEG (Polyethylene glycol)/PVP (Polyvinylpyrrolidone) K30 exhibited improved micrometric properties, compressibility and in addition to improving solubility and dissolution rate.

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Section: Resultssupporting

confidence: 58%

Improvement of Micromeritic, Compressibility and Solubility Characteristics of Linezolid by Crystallo-Co-Agglomeration Technique

Kadam

Patil

2017

Int J App Pharm

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“…The multiple regression analysis for the EE as per the factorial designs revealed the good fit ( R 2 = 0.943) with the following equation:

As per the 3 2 factorial design response surface graph ( Figure 1(b) ) and polynomial equation ( 3 ), EE was mainly governed by concentration of calcium chloride ( X 1 ) which results in lower entrapment in the initial formulations due to weak gel strength and increased entrapment as the concentration of calcium chloride was increased [ 21 ]. The formulated DPI showed less entrapment due to “calcium saturation phenomenon” as compared to F8 and F9 [ 35 ]. The higher concentration of chitosan ( X 2 ) was also responsible for increasing the EE of drug as it has a film forming property encapsulating the inner core of the particle [ 33 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study

Mali

Pawar

Purohit

2014

Journal of Pharmaceutics

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The progress in the development of DPI technology has boosted the use of sensitive drug molecules for lung diseases. However, delivery of these molecules from conventional DPI to the active site still poses a challenge with respect to deposition efficiency in the lung. At same time, serious systemic side effects of drugs have become a cause for concern. The developed budesonide loaded biopolymer based controlled release DPI had shown maximum in vitro lung deposition with least toxicity. The subject of present study, lactose-free budesonide loaded biopolymer based DPI, further corroborates the great potential of antiasthmatic drugs. This technology is expected to revolutionize the approaches towards enhanced therapeutic delivery of prospective drugs.

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“…The compressibility was determined using the values obtained for the bulk and tapped densities using Eq. (1) [32]: % compressibility = tapped density − bulk density tapped density × 100 (1)…”

Section: Particle Propertiesmentioning

confidence: 99%

Hypolipidemic applications of microcrystalline cellulose composite synthesized from different agricultural residues

Adel

El-Shinnawy

2012

International Journal of Biological Macromolecules

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Effect of Additives on the Physicochemical and Drug Release Properties of Pioglitazone Hydrochloride Spherical Agglomerates

Cited by 12 publications

References 13 publications

Improvement of Micromeritic, Compressibility and Solubility Characteristics of Linezolid by Crystallo-Co-Agglomeration Technique

Improvement of Micromeritic, Compressibility and Solubility Characteristics of Linezolid by Crystallo-Co-Agglomeration Technique

Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study

Hypolipidemic applications of microcrystalline cellulose composite synthesized from different agricultural residues

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