Effect of Aerobic Physical Exercise in an Animal Model of Duchenne Muscular Dystrophy

Hoepers, Andreza; Alberti, Adriano; Freiberger, Viviane; Ventura, Luisa; Grigollo, Leoberto Ricardo; Andreu, Cristina Salar; Silva, Bruna Becker da; Martins, Daniel Fernandes; Júnior, Rudy José Nodari; Streck, Emílio L.; Comim, Clarissa M.

doi:10.1007/s12031-020-01565-0

Cited by 5 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10,11 Low-intensity aerobic exercises with an activity level of 1.5 equivalent metabolic tasks (METs) can help improve patients' performance. 12 However, there are limited studies on the role of aerobic exercises in DMD children. Therefore, a comparative study that focuses on the impact of lowintensity aerobic exercises compared with the effect of assisted bicycle training on quality of life and lung function in DMD children is essential.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Low-intensity Aerobic Exercise with Assisted Bicycle Exercise on Quality of Life and Lung Function in Duchenne Muscular Dystrophy

2023

CHCMJ

View full text Add to dashboard Cite

Background: Duchenne muscular dystrophy (DMD) is a genetic disorder that affects males worldwide. Low-intensity aerobic exercises have been proven effective for older populations and may offer potential benefits for individuals with DMD.Objectives: This study assessed low-intensity aerobic exercises and compared their effects with those of assisted bicycle exercises on the quality of life and lung functions of individuals with DMD.Methods: A quasi-experimental study was conducted which involved 38 DMD children divided into two groups. Group I consisted of 19 children who received low-intensity aerobic exercises, while Group II, underwent assisted bicycle exercises. Both groups received a 60-minute exercise regimen and performed deep diaphragmatic breathing exercises for 10 minutes. A home programme was provided to ensure the continuity of the exercises. The study duration was ten weeks. Results:The results showed significantly improved quality of life and lung function for both groups. The student t test values for DMD QoL, FEV1, FVC, and FEV1/VC were 8.22 (p < 0.001), 6.12 (p < 0.001), 11.28 (p < 0.001), and 9.12 (p < 0.001), respectively. Conclusion:This study demonstrated that low-intensity aerobic exercises and assisted bicycle training can improve the quality of life as well as lung functions in individuals with DMD. Moreover, low-intensity aerobic exercises showed greater improvements compared to assisted bicycle exercises.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparison of Low-intensity Aerobic Exercise with Assisted Bicycle Exercise on Quality of Life and Lung Function in Duchenne Muscular Dystrophy

2023

CHCMJ

View full text Add to dashboard Cite

show abstract

“…Physiotherapy works with family and parents and plays to improve the child's skills and QoL (13,14) . Low-intensity aerobic exercises focused on 1.5 metabolic equivalent tasks (METs), which help enhance the activity in the children (15) . There have yet to be studies done on the application of low-intensity aerobic exercises (16) .…”

mentioning

confidence: 99%

“…Low-intensity aerobic exercises were given in addition to the regular physiotherapy interventions. Low-intensity aerobic exercises include wand exercises to encourage the movements of the shoulder, arms circling, arm curls, triceps dips, wall angels, chest press, deltoid raise, leg circle, toe raise, hip movements, and half squats (15,16) .…”

mentioning

confidence: 99%

Effectiveness of low-intensity aerobic exercise with assisted bicycle exercises on quality of life and lung functions in du-chenne muscular dystrophy

et al. 2024

mtprehabjournal

View full text Add to dashboard Cite

Background: Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder caused by abnormalities in the dystrophin gene that affects one in every 3,500 males. In India, approximately 0.8 million were involved. Management is usually multidirectional and more focused on improving the quality of life (QOL), not mortality. Physiotherapy and exercise are an integral part of the management of DMD. Since there were no recommended exercises for DMD, there is a need to create an exercise protocol that improves the QOL. Low-intensity aerobic exercises are highly recommended for older people and are found effective. Objective: The study aimed to identify the effectiveness of low-intensity aerobic exercise with assisted bicycle exercises on QOL and lung functions in DMD. Methods: A randomized controlled trial was conducted at the Institute of Muscular Dystrophy and Research Centre, Jeevan Foundation, Veeravanalur, Tirunelveli Dist. Tamil Nadu, India. The institute has around 200 children with DMD. This study selected 34 children based on the criteria. I, the children, were provided with low-intensity aerobic exercise for seventeen children. Group II provided the children with assisted bicycle exercises for seventeen children. Both groups received exercises for 60 minutes and deep diaphragmatic breathing for 10 minutes. All are given a home program to the children. The total study duration is ten weeks. Results: Data were analysed following the assessment of Quality of life using DMD QoL and the Lung function using a spirometer (FVC, FEV1, FEV1/VC). All the data were collected on day 1, every two months. Parametric tests were used to compare the outcome measures. The student t value for the DMD QOL is 9.66 with p <0.001, the spirometry values of FEV1 are 7.67 with p< 0.001, and FVC is 14.78 with p < 0.001, respectively, and FEV1/VC is 10.81 with p < 0.001. Conclusion: This study concluded that low-intensity aerobic exercises and assisted bicycle training improve the QOL and lung functions. On comparing the interventions, it was found that low-intensity aerobic exercises are better improved than the assisted bicycle group.

show abstract

Swimming Improves Memory and Antioxidant Defense in an Animal Model of Duchenne Muscular Dystrophy

et al. 2021

Self Cite

View full text Add to dashboard Cite

Duchenne muscular dystrophy (DMD) is a genetic disease, which is associated to progressive skeletal muscle degeneration. In humans, DMD has early onset, causes developmental delays, and is a devastating disease that drastically diminishes the quality of life of the young individuals affected. The objective of this study was to evaluate the effects of a swimming protocol on memory and oxidative stress in an animal model of Duchenne muscular dystrophy. Male mdx and wild type mice within 28 days were used in this study. The animals were trained in a stepped swimming protocol for four consecutive weeks. It was veri ed that swimming was able to reduce signi cantly the levels of lipid peroxidation and protein carbonilation in gastrocnemius and hippocampus and striatum in exercised animals. Swimming has also prevented lipid peroxidation in diaphragm. Besides, this swimming protocol was able to increase free thiols in gastrocnemius, diaphragm and in all central nervous system structures. These results showed that a protocol of swimming as an aerobic exercise of low intensity, for four weeks, prevented aversive memory and habituation in mdx mice.

show abstract

Effect of Aerobic Physical Exercise in an Animal Model of Duchenne Muscular Dystrophy

Cited by 5 publications

References 32 publications

Comparison of Low-intensity Aerobic Exercise with Assisted Bicycle Exercise on Quality of Life and Lung Function in Duchenne Muscular Dystrophy

Comparison of Low-intensity Aerobic Exercise with Assisted Bicycle Exercise on Quality of Life and Lung Function in Duchenne Muscular Dystrophy

Effectiveness of low-intensity aerobic exercise with assisted bicycle exercises on quality of life and lung functions in du-chenne muscular dystrophy

Swimming Improves Memory and Antioxidant Defense in an Animal Model of Duchenne Muscular Dystrophy

Contact Info

Product

Resources

About