Effect of Afghan Senjed (Elaeagnus Angustifolia L.) Leaves Aqueous alcoholic Extract on Blood Glucose Level of Diabetic Rats

Sadat, Hamida; Alami, Kawsar; Mousavi, Sayed Yousof

doi:10.5530/pj.2020.12.170

Cited by 7 publications

(7 citation statements)

References 23 publications

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“…Researchers all over the world are also focused on the effect of medicinal plants and their constituents on diabetes, because of their fewer side effects than synthetic drugs. [12][13][14] In traditional medicine, it is recommended to use herbs combinations, because there are some reports that multiple herbs combinations have more effects than individual herbs. [15] Many researchers consider the combination therapy as a new and effective therapeutic strategy for controlling hyperglycemia.…”

Section: Introductionmentioning

confidence: 99%

Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Hussaini¹,

Askndari²,

Alami³

et al. 2021

Int j pharm phytopharm res

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The prevalence of type 2 diabetes is increasing and considered a major cause of mortality in the world. Medicinal plants are a part of complementary and alternative medicine, which have wide use in the treatment of diabetes. Besides, combination therapy as an effective therapeutic strategy is highly recommended for controlling hyperglycemia. The present study aimed to determine the hypoglycemic effect of Afghan Rheum Ribes L. and Urtica Dioica L. extracts either alone or in combination on blood glucose level in type 2 diabetic rats. Diabetes was induced by single-dose administration of Streptozotocin (50 mg/kg) in rats. Diabetic rats were received intraperitoneal administration of R. Ribes aqueous extract (40 and 60 mg/kg), U. Dioica aqueous-alcoholic extract (100 and 200 mg/kg), and their combination for 21 days. The fasting blood glucose and body weight of rats were determined on 0, 7 th , 14 th , and 21 st days. The results showed that R. Ribes extract (40 and 60 mg/kg), U. Dioica extract (200 mg/kg), and their combination could significantly decrease the blood glucose level on 0, 7 th , 14 th , and 21 st days (P<0.0001). Only 200 mg/kg of U. Dioica had a positive effect on the bodyweight loss of diabetic rats (P<0.01). It can be concluded that Afghan R. Ribes and U. Dioica extracts and their combination have a hypoglycemic effect. However, their combinations do not show any synergic or antagonistic effects.

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Section: Introductionmentioning

confidence: 99%

Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Hussaini¹,

Askndari²,

Alami³

et al. 2021

Int j pharm phytopharm res

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“…In addition, studies showed that there is a glucose intolerance in almost all diabetic patients (30). Also, the glucose tolerance test indicates insulin secretion and its function, so GTT is used to evaluate insulin secretion and sensitivity (6). The results of this study showed that A. Repens extract could decrease the blood glucose level after administration of a glucose load.…”

Section: Discussionmentioning

confidence: 66%

“…Most of these complications have resulted from chronic hyperglycemia (4). Therefore, the main purpose of diabetes treatment is the prevention of its complications through the control of hyperglycemia (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Effect of Afghan Talkhak (Acroptilon Repens) Aqueous Extract on Blood Glucose Level in Diabetic Rats

Bayat¹,

Alami²,

Mousavi³

2021

IJAM

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The aim of this study is the evaluation of the effect of Afghan talkhak (Acroptilon Repens) root aqueous extract on blood glucose level of diabetic rats. Rats were randomly divided into 5 groups (1 Normal, 1 Diabetic and 3 extract groups). Experimental diabetes was induced by single-dose intraperitoneal (i.p.) injection of streptozotocin (55 mg/kg) in diabetic and extracts groups. 72 hour later, the induction of diabetes was approved and extract groups were received Acroptilon Repens aqueous extract (200, 300, 400 mg/kg) by i.p. administration for 15 days. The blood glucose level and body weight of all groups were measured on baseline, 0, 5, 10 and 15th days. The glucose tolerance test had performed on days 0 and 15. The results showed that aqueous extract of Afghan Acroptilon Repens in extract groups (200 and 300 mg/kg) could significantly decrease the blood glucose level, and improve the glucose tolerance, as compared with the diabetic group (P<0.0001). However, there was not a significant difference in the blood glucose level and glucose tolerance test among the group which received 400 mg/kg dose of Acroptilon Repens and the diabetic group (P>0.05). In conclusion, Acroptilon Repens root aqueous extract possessed antihyperglycemic activity.

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“…7 Many researchers are focused on the use of natural compounds and medicinal plants. 28 There are many plants and nuts such as Convulvulus pluricaulis, Evolvulus alsinoides, Canscora decussate, Juglans regia which are used for enhancement of learning and memory. 18,[29][30][31] In general, nuts have various beneficial constituents.…”

Section: Discussionmentioning

confidence: 99%