Effect of ageing and single nucleotide polymorphisms associated with the risk of aggressive prostate cancer in a New Zealand population

Vaidyanathan, Venkatesh; Naidu, Vijay; Karunasinghe, Nishi; Kao, Chi Hsiu-Juei; Pallati, Radha; Jabed, Anower; Marlow, Gareth; Kallingappa, Prasanna; Ferguson, Lynnette R.

doi:10.1039/c7mb00203c

Cited by 2 publications

(2 citation statements)

References 63 publications

(87 reference statements)

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“…Single nucleotide polymorphisms (SNPs), a common type of genetic variation, present in lncRNAs have been found to be able to affect the structure, expression level, and function of lncRNAs by interfering with the corresponding target mRNAs [7]. Evidence has demonstrated that SNPs in lncRNA genes were related to the occurrence of various diseases, particularly cancer [8]. Therefore, lncRNA polymorphisms are considered to be potentially associated with the mechanism underlying cancer susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis

Dong¹,

Gao

et al. 2020

Disease Markers

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Purpose. Long noncoding RNAs (lncRNAs) have been widely studied, and single nucleotide polymorphisms (SNPs) in lncRNAs are considered to be genetic factors that influence cancer susceptibility. The lncRNA GAS5, MEG3, and PCAT-1 polymorphisms are shown to be possibly associated with cancer risk. The aim of this meta-analysis was to systematically evaluate this association. Methods. Studies were selected from PubMed, Web of Science, Embase, Google Scholar, Cochrane Library, the Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biomedical Literature Database (CBM) through inclusion and exclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the random-effects model or fixed-effects model to assess the association between lncRNA polymorphisms and cancer susceptibility. Metaregression and publication bias analyses were also conducted. All analyses were performed using the Stata 12.0 software. Results. Sixteen articles (covering 13750 cases and 17194 controls) were included in this meta-analysis. A significant association between SNP rs145204276 and gastric cancer risk was observed (del vs. ins: OR = 0:79, 95%CI = 0:72-0:86; del/del vs. ins/ins+del/ins: OR = 0:74, 95%CI = 0:59-0:91; del/ins vs. ins/ins: OR = 0:84, 95%CI = 0:67-1:05). For rs16901904, a decreased cancer risk was observed in three genetic models (C vs. T: OR = 0:79, 95%CI = 0:70-0:90; CC vs. CT+TT: OR = 0:49, 95%CI = 0:37-0:65; CC vs. TT: OR = 0:49, 95%CI = 0:37-0:66). No statistical significance was found in the metaregression analysis. For all of the included SNPs, no publication bias was found in all genotype models. Conclusions. The rs145204276 SNP in lncRNA GAS5 is likely to be associated with gastric cancer risk, whereas the rs16901904 SNP in lncRNA PCAT-1 bears association with a decreased cancer risk.

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Section: Introductionmentioning

confidence: 99%

Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis

Dong¹,

Gao

et al. 2020

Disease Markers

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“…In New Zealand (NZ) there were 3199 PC registrations and 607 PC-related deaths in 2012[3]. The status of PC risk varies between individuals in terms of the patient’s lifestyle and biological characteristics [4–6]. For PC management purposes, it is important to differentiate between men carrying indolent cancers from those with high-risk cancers.…”

Section: Introductionmentioning

confidence: 99%

Interaction between leukocyte aldo-keto reductase 1C3 activity, genotypes, biological, lifestyle and clinical features in a prostate cancer cohort from New Zealand

et al. 2019

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Introduction Aldo-keto reductase 1C3 (AKR1C3) is known for multiple functions including its catalytic activity towards producing extra-testicular androgen. The present study is towards understanding interaction between biological, lifestyle and genetic impacts of AKR1C3 and their influence on clinical factors in a prostate cancer (PC) cohort from New Zealand (NZ). Method Characteristics of 516 PC patients were collected from the Auckland Regional Urology Facility, NZ. These men were genotyped for the AKR1C3 rs12529 single nucleotide polymorphism (SNP). The leukocyte AKR1C3 activity was measured in a sub-cohort. Variability of leukocyte AKR1C3 activity between biological, lifestyle and clinical features as well as correlation between biological and clinical features were assessed with and without genetic stratification. Results The leukocyte AKR1C3 activity was associated with age at diagnosis (0.51 vs 0.34 μM coumberol units for >69y vs ≤69y, P = 0.03); and with anatomic stage/prognostic grouping among the AKR1C3 rs12529 CC genotype carriers (0.50 vs 28 μM coumberol units among low- and high-risk groups respectively, P = 0.02). Significant correlation between leukocyte AKR1C3 activity and age at PC diagnosis was also observed (correlation coefficient 0.20 and P = 0.02). Ever- smoking impacted both age and PSA at PC diagnosis among AKR1C3 rs12529 GG and CG genotype carriers respectively. Age at diagnosis significantly correlated with PSA at diagnosis in the main (correlation coefficient 0.29, and P<0.001) and sub-cohorts (correlation coefficient 0.24, and P = 0.01); and those carrying the AKR1C3 rs12529 CG and GG genotypes in both the main (correlation coefficient 0.30, and P<0.001 and correlation coefficient 0.35, and P<0.001 respectively) and sub-cohorts (correlation coefficient 0.43, and P<0.001 and correlation coefficient 0.39, and P = 0.06 respectively); but not with those carrying the CC genotype. Conclusions Age dependent PSA thresholds in PC screening could have been valid only in men carrying the AKR1C3 rs12529 CG and GG genotypes in this NZ cohort.

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Effect of ageing and single nucleotide polymorphisms associated with the risk of aggressive prostate cancer in a New Zealand population

Cited by 2 publications

References 63 publications

Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis

Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis

Interaction between leukocyte aldo-keto reductase 1C3 activity, genotypes, biological, lifestyle and clinical features in a prostate cancer cohort from New Zealand

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