Effect of Allium cepa (Onion) Extract on Cadmium-induced Nephrotoxicity in Rats

Ige, Serah Funke; Akhigbe, R.E.; Adewale, A.A.; Badmus, Jelili A.; Olaleye, Samuel Babafemi; Ajao, F.O.; Saka, W.A.; Owolabi, Oluwaseun

doi:10.3923/krj.2011.41.47

Cited by 30 publications

(21 citation statements)

References 13 publications

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“…The present study demonstrated that administration of AlCl3 led to hepatotoxicity. Many studies have documented that administration of cadmium, arsenic acid and AlCl3 impaired liver function [6,7,8,26]. The change in serum ALT, ALP, bilirubin and total protein levels in this study clearly indicated a significant damage of hepatocytic cell membranes [4] resulting in leakage of these chemical substances into the systemic circulation and attenuation of synthetic capacity of the organ.…”

Section: Discussionmentioning

confidence: 91%

“…Allium cepa was prepared following procedures from previous studies [6,14]. Briefly, fresh common onion (Allium cepa) bulbs were rinsed thoroughly in distilled water, air dried, and 200 g was then blended.…”

Section: Preparation Of Allium Cepa Extractmentioning

confidence: 99%

“…(2011) [6]. Serum liver enzymes (ALT and AST) were also determined using standard kit (Biosystems S.A Barcelona-Spain).…”

Section: Sample Collectionmentioning

confidence: 99%

“…In animal studies, experimental hepatotoxicity was associated with alterations in liver function test such as total plasma protein, plasma liver enzymes (ALT, AST and alkaline phosphatase) and plasma bilirubin [6][7][8]. A study by Ige et al (2011) [6] on cadmium-induced hepatic damage showed a decrease in total serum protein and significant increases in serum ALT and AST activities in male rats.…”

Section: Introductionmentioning

confidence: 99%

“…A study by Ige et al (2011) [6] on cadmium-induced hepatic damage showed a decrease in total serum protein and significant increases in serum ALT and AST activities in male rats. Arsenic and mercury loading were also associated with increases in plasmatic activities of AST, ALT and alkaline phosphatase in rats [7,9].…”

Section: Introductionmentioning

confidence: 99%

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Allium cepa Mitigates Aluminum Chloride-Induced Hepatotoxicity in Male Wistar Rats

Ige¹,

Adeniyi²,

Iyalla³

2017

J Biomedical Sci

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Allium cepa (Common Onion), one of the most widely grown crops in world, is believed to possess medicinal potency. The present study was designed to investigate the effect of Allium cepa (ACE) administration on oxidative stress-mediated hepatotoxicity following aluminum chloride (AlCl3) administration. 24 adult male wistar rats weighing 175 g were randomly divided into vehicle-treated (control), ACE, aluminum chloride (AlCl3) and ACE+AlCl3 groups. Rats were given single oral administrations of 100mg/kg body weight of AlCl3 and 1 mL/0.1 kg body weight of ACE for four weeks. When compared with vehicle-treated, AlCl3 administration caused a significant decrease in serum total protein (TP) and an increase in serum levels of alanine transaminase (ALT), aspartate transaminase (AST) and total bilirubin. On the other hand, ACE treatment significantly improved serum TP but depressed serum levels of ALT, AST and total bilirubin. There was no significant change in these biomarkers of liver function in ACE+AlCl3 group compared with the vehicle-treated group. Furthermore, while AlCl3 group was characterized by a significant rise in hepatic malondialdehyde (MDA) and a decrease in hepatic superoxide dismutase (SOD) and catalase activities, ACE group exhibited a significant low hepatic MDA and a high hepatic SOD and catalase activities. However, none of these antioxidant markers changed in ACE+AlCl3 group compared with vehicle-treated. Therefore, we conclude that ACE mitigates hepatotoxic effect of AlCl3 administration through regulation of hepatic oxidant/antioxidant system.

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Section: Discussionmentioning

confidence: 91%

Section: Preparation Of Allium Cepa Extractmentioning

confidence: 99%

“…(2011) [6]. Serum liver enzymes (ALT and AST) were also determined using standard kit (Biosystems S.A Barcelona-Spain).…”

Section: Sample Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Allium cepa Mitigates Aluminum Chloride-Induced Hepatotoxicity in Male Wistar Rats

Ige¹,

Adeniyi²,

Iyalla³

2017

J Biomedical Sci

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Protective Effects of Onion Extract on Cadmium-Induced Oxidative Stress, Histological Damage, and Apoptosis in Rat Heart

Alpsoy

Kanter

Aktaş

et al. 2014

Biol Trace Elem Res

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To date, there is no available information on the protective effect of onion (Allium cepa) extract (AcE) on cadmium (Cd)-induced cardiotoxicity. The present study was performed to assess the possible antioxidant and anti-apoptotic roles of AcE in Cd-induced cardiotoxicity in rats. A Cd group was injected subcutaneously with CdCl2 dissolved in saline at a dose of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in the AcE-treated group were given 1 ml of AcE via intragastric intubation for 30 days. The rats intoxicated with Cd for 30 days showed increased tissue malondialdehyde (MDA) levels and decreased levels of the enzymatic antioxidants superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in cardiac tissue. AcE attenuated these adverse effects of Cd. After Cd exposure, histological abnormalities were observed, including myofibrillar loss, vacuolization of cytoplasm and irregularity of myofibrils. These histological alterations were effectively attenuated by the treatment with AcE. Furthermore, our data indicate a significant reduction of apoptosis in the cardiomyocytes of the Cd group treated with AcE therapy. Animal studies show antioxidant effects of AcE. But to date, no study reported the effect of AcE on biochemical and histopathological changes due to Cd induced on rat heart. Our study showed that AcE therapy reduced Cd-induced oxidative stress and apoptosis, possibly through its antioxidant and anti-apoptotic activity.

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Suppression of uric acid generation and blockade of glutathione dysregulation by L-arginine ameliorates dichlorvos-induced oxidative hepatorenal damage in rats

Saka

Akhigbe

Abidoye

et al. 2021

Biomedicine & Pharmacotherapy

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Effect of Allium cepa (Onion) Extract on Cadmium-induced Nephrotoxicity in Rats

Cited by 30 publications

References 13 publications

Allium cepa Mitigates Aluminum Chloride-Induced Hepatotoxicity in Male Wistar Rats

Allium cepa Mitigates Aluminum Chloride-Induced Hepatotoxicity in Male Wistar Rats

Protective Effects of Onion Extract on Cadmium-Induced Oxidative Stress, Histological Damage, and Apoptosis in Rat Heart

Suppression of uric acid generation and blockade of glutathione dysregulation by L-arginine ameliorates dichlorvos-induced oxidative hepatorenal damage in rats

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