Effect of aluminium phosphide (ALP) gas inhalation exposure on adipose tissue characteristics and histological toxicity in male rats

Tahergorabi, Zoya; Zardast, Mahmoud; Naghizadeh, Ali; Mansouri, Borhan; Nakhaei, Iman; Zangouei, M

doi:10.1080/16583655.2020.1820155

Cited by 6 publications

(4 citation statements)

References 36 publications

(43 reference statements)

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“…In particular, the dose and duration were matter of debate (Snider 1983 ; EFSA 2009 ). Among other things, the slow release of gas and the very strong convulsions evoked determined the score (Meehan 1984 ; Anand et al 2012 ; Shakeri & Mehrpour 2015 ; Tahergorabi et al 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Assessing animal welfare impact of fourteen control and dispatch methods for house mouse (Mus musculus), Norway rat (Rattus norvegicus) and black rat (Rattus rattus)

et al. 2023

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Population control of the house mouse (Mus musculus), Norway rat (Rattus norvegicus) and black rat (Rattus rattus) is common practice worldwide. Our objective was to assess the impact on animal welfare of lethal and non-lethal control methods, including three dispatch methods. We used the Sharp and Saunders welfare assessment model with eight experts scoring eleven control methods and three dispatch methods used on the three species. We presumed the methods were performed as prescribed, only taking into account the effect on the target animal (and not, for example, on non-target catches). We did not assess population control efficacy of the methods. Methods considered to induce the least suffering to the target animal were captive-bolt traps, electrocution traps and cervical dislocation, while those with the greatest impact were anticoagulants, cholecalciferol and deprivation. Experts indicated considerable uncertainty regarding their evaluation of certain methods, which emphasises the need for further scientific research. In particular, the impact of hydrogen cyanide, chloralose and aluminium phosphide on animal welfare ought to be investigated. The experts also stressed the need to improve Standard Operating Procedures and to incorporate animal welfare assessments in Integrated Pest Management (IPM). The results of our study can help laypeople, professionals, regulatory agencies and legislators making well-informed decisions as to which methods to use when controlling commensal rodents.

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Section: Resultsmentioning

confidence: 99%

Assessing animal welfare impact of fourteen control and dispatch methods for house mouse (Mus musculus), Norway rat (Rattus norvegicus) and black rat (Rattus rattus)

et al. 2023

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“…Brodifacum can cause neurological effects, histopathological, biochemical and hematological damage, and immune suppression, and has been linked to internal bleeding, organ failure, paralysis, and coma [35,36]. Exposure to aluminum phosphide can alter physiological and histological parameters, leading to lung, kidney, and liver damage, congested heart failure, and low blood pressure [37]. Consistent with the current study, Njoku et al [38] detected pesticides used as preservatives in vegetables and fruits obtained from markets in Lagos, Nigeria.…”

Section: Methods Of Fruit and Vegetable Preservation By The Participantsmentioning

confidence: 99%

Demographics and Chemical Preservatives Used by Vegetable and Fruit Retailers Selected Across Markets in Lagos, Southwestern Nigeria

Yahaya,

Ukeoma,

Musa

et al. 2023

Trop. Environ. Biol. Technol.

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Literatures show that several thousands of Nigerians die yearly from poisoning caused by chemical preservatives used for vegetables and fruits. Thus, there is the need to prioritize the safety of vegetables and fruits consumed in every locality in the country. The demographics of 50 vegetable and fruit retailers randomly selected across markets in Lagos, Nigeria, as well as types of chemical preservatives used, were determined in this study. The survey revealed that 32 (64%) of the participants were females, while 18 (36%) were males. Participants with no formal education were 2 (4%), those with primary education were 13 (26%), those with secondary education consisted of 24 (46%), and those with tertiary education made up of 11 members (22%). 16 (32%) participants were Hausa, 13 (26%) participants were Yoruba, 12 (24%) participants were Igbo, and the rest were sub-ethnic groups. 28 (56%) participants use natural methods, while 22 (44.00%) participants use chemical preservatives, mostly pesticides. Of the 22 participants that use chemicals, gammalin-20 was used by 6 (27%) participants, sniper was used by 4 (18%) participants, aluminum phosphide was used by 4 (18%) participants, DDT (otapiapia) was used by 3 (14%) participants, carbide was used by 3 (14%) participants, and brodifacum was used by 2 (9%) participants. Based on these results, there is a significant use of chemical preservatives across markets in Lagos, which can predispose consumers to health hazards. Vegetable and fruit retailers and consumers in the city need to be sensitized on the health threat posed by chemical preservatives.

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“…1 This chemical, which was first presented as a perfect pesticide in 1973, is now used in the form of yellow or dark gray crystals under the brand names pesticide, insecticide, and rodenticide. 2 Humans cannot absorb this substance through their skin, so oral ingestion and inhalation are the two main ways it can poison an individual. Additionally, the main mechanism of poisoning by this substance is the release of the gas Phosphine (PH 3 ), which is created when aluminum phosphide comes into contact with water.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the effect of N-acetylcysteine on aluminum phosphide toxicity in rats

et al. 2022

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Aluminum Phosphide (ALP) is one of the most dangerous pesticides. When it comes into contact with water, it emits Phosphine (PH3) gas, which causes poisoning and death in many people. The purpose of this study is to look into the role of N-acetylcysteine in the treatment of aluminum phosphide toxicity in rats. In this study, 30 male Wistar rats were fed with aluminum phosphide orally. After 15 minutes, N-acetylcysteine was administered intraperitoneally. The antioxidant enzymes glutathione S-Transferase (GST), Superoxide Dismutase (SOD), Catalase (CAT), glutathione (GSH), Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), and Alkaline Phosphatase (ALK) were studied in blood plasma. CAT, GST, and GSH concentrations in plasma, liver, and kidneys of rats infected with aluminum phosphide decreased, while AST, ALT, and ALK concentrations increased. The levels of all enzymes studied approached normal after N-acetylcysteine administration, and the rats survived for up to 12-15 hours. According to the findings of this study, N-acetylcysteine (NAC) at a dose of 10 mg/kg improves hepatic manifestations and prevents liver necrosis, so it can be considered a potential therapeutic agent in the treatment of this poisoning.

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Effect of aluminium phosphide (ALP) gas inhalation exposure on adipose tissue characteristics and histological toxicity in male rats

Cited by 6 publications

References 36 publications

Assessing animal welfare impact of fourteen control and dispatch methods for house mouse (Mus musculus), Norway rat (Rattus norvegicus) and black rat (Rattus rattus)

Assessing animal welfare impact of fourteen control and dispatch methods for house mouse (Mus musculus), Norway rat (Rattus norvegicus) and black rat (Rattus rattus)

Demographics and Chemical Preservatives Used by Vegetable and Fruit Retailers Selected Across Markets in Lagos, Southwestern Nigeria

Investigation of the effect of N-acetylcysteine on aluminum phosphide toxicity in rats

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