Effect of an estrogen‐deficient state and its therapy on bone loss resulting from an experimental periodontitis in rats

Duarte, Poliana Mendes; Gonçalves, Patrícia Furtado; Sallum, Antônio Wilson; Sallum, Enílson Antônio; Casati, Márcio Zaffalon; Nociti, Francisco Humberto

doi:10.1111/j.1600-0765.2004.00714.x

Cited by 43 publications

(63 citation statements)

References 16 publications

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“…24 A possible relationship between estrogen deficiency and alveolar bone loss without the induction of experimental of periodontitis was not verified in this study. Similarly, some studies on animals have observed that osteoporosis itself may not be capable of causing alveolar bone loss; 9,10,25 in contrast, other studies have shown that estrogen deficiency may have a direct effect on alveolar bone loss in the furcation region. 9 In the present study, estrogen deficiency for 90 days resulted in greater ligature-induced bone loss in rats.…”

Section: Discussionmentioning

confidence: 98%

“…Similarly, some studies on animals have observed that osteoporosis itself may not be capable of causing alveolar bone loss; 9,10,25 in contrast, other studies have shown that estrogen deficiency may have a direct effect on alveolar bone loss in the furcation region. 9 In the present study, estrogen deficiency for 90 days resulted in greater ligature-induced bone loss in rats. In a previous study, 9 estrogen deficiency in rats for 81 days resulted in significant alveolar bone loss in experimental periodontitis when the rats were compared with estrogen-sufficient rats; the findings were determined histological in the furca region of the first mandibular molar.…”

Section: Discussionmentioning

confidence: 98%

“…Animal models have been used to investigate the influence of estrogen deficiency on the progression of periodontitis 9,10 because the structure of the periodontal tissue in rats is very similar to that of humans. 16 Therefore, ovariectomy-induced osteopenia in the rat produces skeletal responses similar to those in post-menopausal women.…”

Section: Discussionmentioning

confidence: 99%

“…15 Few studies exist that evaluate the relationship between estrogen deficiency and periodontal disease associated with bone loss in rats. 9,10 Thus, the aim of this study was to morphometrically evaluate the influence of different durations of estrogen deficiency on the ligature-induced alveolar bone loss.…”

Section: Declaration Of Interestsmentioning

confidence: 99%

“…7,8 Ovariectomized rats have been used as an animal model to simulate human postmenopausal accelerated bone loss. 9,10 Previous studies have…”

Section: Introductionmentioning

confidence: 99%

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Influence of different durations of estrogen deficiency on alveolar bone loss in rats

et al. 2011

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The purpose of this study was to morphometrically evaluate the influence of different durations of ovariectomy-induced estrogen deficiency on alveolar bone loss associated with ligature-induced bone loss in rats. Sixty female Wistar rats were randomly assigned to ovariectomy (OVX test group) or sham operation (SHAM control group). The OVX and SHAM groups were each distributed into three subgroups of ten rats each according to the duration of estrogen deficiency (30, 60 and 90 postoperative days). In all groups, for the last 30 days of the experimental period, cotton ligatures were placed around the cervix of the right upper second molar; the contralateral tooth was left unligated to serve as a control. The maxillary bones were removed, and the alveolar bone loss was analyzed by measuring the distance between the cementoenamel junction and the alveolar bone crest at the buccal site of the right upper second molar. A comparison between the ligated and unligated groups verified the presence of ligature-induced alveolar bone loss (p < 0.05). No significant differences were observed among the unligated groups (p > 0.05). A significant increase in bone loss was observed when ligation occurred 90 days after ovariectomy compared with the sham group (p < 0.05). These results demonstrate that long-term estrogen deficiency affects ligatureinduced alveolar bone loss.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Declaration Of Interestsmentioning

confidence: 99%

“…7,8 Ovariectomized rats have been used as an animal model to simulate human postmenopausal accelerated bone loss. 9,10 Previous studies have…”

Section: Introductionmentioning

confidence: 99%

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Influence of different durations of estrogen deficiency on alveolar bone loss in rats

et al. 2011

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Effects of the Pulsed Electromagnetic Fields on Experimental Periodontitis and Estrogen Deficiency

Bernardo

Ferreira

Nunes

et al. 2022

Bioelectromagnetics

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Periodontitis is an inflammatory disease resulting from a complex polymicrobial infection that causes tissue destruction in susceptible individuals. Osteoporosis has been associated with greater clinical attachment loss in patients with periodontitis. Experimental studies have shown positive results in the treatment of osteoporosis through pulsed electromagnetic field (PEMF) stimulation. The aim of this study was to evaluate the effects of PEMF in the presence of estrogen deficiency associated with periodontitis, verifying its role in bone metabolism and in the inflammatory response. Sixty rats were divided into four groups: Sham surgery + ligature-induced periodontitis (P); Sham surgery + ligatureinduced periodontitis + PEMF therapy (P + PEMF); Ovariectomy surgery + ligature-induced periodontitis (P + OVX); Ovariectomy surgery + ligature-induced periodontitis + PEMF therapy (P + OVX + PEMF). The area of bone loss in the furcation region (BL), connective tissue attachment loss (CTAL) and alveolar bone loss (ABL), BV/TV and BMD were evaluated. In addition to immunohistochemical labelling of RANKL, OPG, and TRAP and the inflammatory response of interleukin (IL)-1b, IL-6, TNF-α, IL-10, and vascular endothelial growth factor. P + OVX showed significant BL in relation to P + PEMF and the greatest CTAL and ABL. P + OVX and P + OVX + PEMF showed a significant reduction in BV/TV (%). P and P + PEMF showed a significantly lesser amount of Tb.Sp (mm) while P + OVX and P + OVX + PEMF showed a lesser of Tb.N. P + PEMF had the greatest BMD. P + OVX presented higher RANKL and lower OPG immunolabeling than other groups. P + PEMF and P + OVX + PEMF showed a reduction on all biomarkers evaluated. The application of PEMF seems to attenuate the effects of bone loss in the presence of periodontitis and ovariectomy. Bioelectromagnetics. 43:426-437, 2022.

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Lithium chloride assuages bone loss in experimental periodontitis in estrogen-deficient rats

et al. 2019

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Effect of an estrogen‐deficient state and its therapy on bone loss resulting from an experimental periodontitis in rats

Abstract: Estrogen administration may prevent the direct effect of an estrogen-deficient state on alveolar bone; however, neither estrogen nor calcitonin administration could prevent this effect when associated with a response to a plaque-related inflammatory process.

Cited by 43 publications

References 16 publications

Influence of different durations of estrogen deficiency on alveolar bone loss in rats

Influence of different durations of estrogen deficiency on alveolar bone loss in rats

Effects of the Pulsed Electromagnetic Fields on Experimental Periodontitis and Estrogen Deficiency

Lithium chloride assuages bone loss in experimental periodontitis in estrogen-deficient rats

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