Effect of an Excessive Intake of Quercetin on the Vitamin E Level and Antioxidative Enzyme Activities of Mouse Liver under Paraquat-Induced Oxidative Stress

Bando, Noriko; Wakamatsu, Saori; Terao, Junji

doi:10.1271/bbb.70282

Cited by 11 publications

(3 citation statements)

References 23 publications

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“…Similar results found that excess dietary GSPs could not have more beneficial effects on broiler (Wang et al, 2008;Zhou et al, 2013), piglets (Xie et al, 2012), and hybrid Crucian carp (Huang et al, 2012). The excessive intake of GSPs and other flavonoids have been suggested to exert adverse effects on the body by acting as prooxidants that generate free radicals and induce biological damage (Fine, 2000;Galati and O'Brien, 2004;Bando et al, 2007). Hence, the adequate GSPs level should be supplemented in fish diet according to the stress degree.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Grape Seed Proanthocyanidins on Growth Performance, Some Serum Biochemical Parameters and Body Composition of Tilapia (Oreochromis Niloticus) Fingerlings

Zhai¹,

Lu²,

Chen³

2014

Italian Journal of Animal Science

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The present study was performed with tilapia (Oreochromis niloticus) to evaluate the effects of diet supplementation with grape seed proanthocyanidins (GSPs) on fish growth performance, some serum parameters and body composition. Three hundred tilapia fingerlings with the initial average body weight of 8.25±0.07 g were randomly divided into five treatment groups with four replicates in each group and 15 fish in each replicate. The dietary GSPs levels of five treatment groups were 0 (control group), 200, 400, 600, and 800 mg/kg, respectively. The trial period was 49 days. Growth performance parameters were significantly improved by GSPs supplementation (P<0.05), while survival rates were similar among all groups (P>0.05). Serum parameter results showed that activities of aminotransferase aspartate in 200 and 400 mg/kg GSPs groups and alanine aminotransferase in 400 mg/kg GSPs group were lowered significantly (P<0.05). Levels of triglyceride and total cholesterol (except 200 mg/kg GSPs group) were significantly lowered, while lysozyme activity and albumin level were significantly higher in fish of GSPs supplemented groups, independently from the level of supplementation. The highest crude protein level and lowest crude lipid level were found in fish of all GSPs supplemented groups, while levels of moisture and ash in fish of all groups were similar (P>0.05). The results indicated that dietary 200 mg/kg GSPs could exert beneficial effects on growth and body composition of tilapia fingerlings, and ameliorate serum biochemistry parameters related to health status.

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Section: Discussionmentioning

confidence: 99%

Effects of Dietary Grape Seed Proanthocyanidins on Growth Performance, Some Serum Biochemical Parameters and Body Composition of Tilapia (Oreochromis Niloticus) Fingerlings

Zhai¹,

Lu²,

Chen³

2014

Italian Journal of Animal Science

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“…9,10) The physiologically conceivable activities of various quercetin metabolites have been reported. 11) Although we have examined the bioavailability of a quercetin intake by rabbits, 12) rats, 13,14) mice, 15) and humans, [16][17][18] the relative contribution of different types of conjugates to the biological activity in vivo has not yet been clarified. It is expected that the B-ring catechol moiety of flavonoids represents the radical scavenging action of the metabolites in vitro.…”

mentioning

confidence: 99%

Different Profiles of Quercetin Metabolites in Rat Plasma: Comparison of Two Administration Methods

Kawai

Saito

Nishikawa

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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The bioavailability of polyphenols in human and rodents has been discussed regarding their biological activity. We found different metabolite profiles of quercetin in rat plasma between two administration procedures. A single intragastric administration (50 mg/kg) resulted in the appearance of a variety of metabolites in the plasma, whereas only a major fraction was detected by free access (1% quercetin). The methylated/non-methylated metabolites ratio was much higher in the free access group. Mass spectrometric analyses showed that the fraction from free access contained highly conjugated quercetin metabolites such as sulfo-glucuronides of quercetin and methylquercetin. The metabolite profile of human plasma after an intake of onion was similar to that with intragastric administration in rats. In vitro oxidation of human low-density lipoprotein showed that methylation of the catechol moiety of quercetin significantly attenuated the antioxidative activity. These results might provide information about the bioavailability of quercetin when conducting animal experiments.

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“…Acute exercise causes muscular tissue damage, lipid reproduction in membranes, and formation of free radicals spectrum. In damaged tissue, phospholipase leads to proteinase enzyme activation and arachidonic acid release in cell membranes, which causes increase in production of free radical (Bando, Wakamatsu, & Terao, 2007).…”

Section: Literature Reviewmentioning

confidence: 99%

Effects of Different-Term Acute Swimming Exercises on Oxidative Stress Parameters in Rat Cerebellum Tissue

Akyüz¹

2016

UCER-B

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Background: Regular physical activity may prevent the onset of a large range of pathological conditions, from heart diseases to mental disorders (depression, anxiety, panic disorder, social phobia, etc.), ischemia, and neurodegenerative diseases. Although beneficial effects of exercise are not known exactly for molecular mechanisms, several hypotheses have been proposed about this research. The purpose of this study is to examine the acute effects of oxidative stress parameters on the cerebellum tissue of the different swimming exercises. Methods:Telve week-old male Albino Wistar rats (n = 32) were used in this study. Rats were divided randomly into four groups: control, short-term exercise (15 mins.), moderate-term exercise (30 mins.), and long-term exercise (60 mins.) group. Glass tank containing water for swimming exercise (L x W x H, 100 x 50 x 50 cm) was used as pool. Results:The differences among superoxide dysmutase (SOD), glutathione (GSH), and malondialdehyde (MDA) were studied. When the difference were examined between SOD levels, short-term and moderate-term exercise groups were statistically significant different from other groups (p < 0.05). When GSH levels were examined, moderate-term and long-term groups were statistical different than other groups (p < 0.05). When MDA levels were examined, all exercise groups being compared with the control group had statistically significant differences (p < 0.05).Conclusions: SOD, GSH, and MDA levels were found to be higher in the moderate-term exercising rat's cerebellum tissue compared to rats that other groups.

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Effect of an Excessive Intake of Quercetin on the Vitamin E Level and Antioxidative Enzyme Activities of Mouse Liver under Paraquat-Induced Oxidative Stress

Cited by 11 publications

References 23 publications

Effects of Dietary Grape Seed Proanthocyanidins on Growth Performance, Some Serum Biochemical Parameters and Body Composition of Tilapia (Oreochromis Niloticus) Fingerlings

Effects of Dietary Grape Seed Proanthocyanidins on Growth Performance, Some Serum Biochemical Parameters and Body Composition of Tilapia (Oreochromis Niloticus) Fingerlings

Different Profiles of Quercetin Metabolites in Rat Plasma: Comparison of Two Administration Methods

Effects of Different-Term Acute Swimming Exercises on Oxidative Stress Parameters in Rat Cerebellum Tissue

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