Effect of an LHRH Analogue on Testicular Function in the Immature Monkey (Macaca mulatta)

Abstract

Response of the immature monkey testis to an LHRH analogue, D-Ser-(TBu)6-EA10-LHRH, has been assessed by measuring testicular androgen production in the immature rhesus monkey. Administration of the analogue (2.5 micrograms X 2 daily) for 5 days induced a significant increase in testicular testosterone compared with untreated animals. The response of the control and the LHRH-agonist treated monkey testis to gonadotrophin (hCG) was assessed by in vitro androgen production. Whereas the testicular tissue from LHRH analogue primed monkeys responded to in vitro stimulation of hCG, no significant increase in androgen production was observed when testicular tissue from untreated animals was incubated with the gonadotrophin. The present data suggest a functional differentiation of the immature monkey testis following the LHRH analogue treatment.