Effect of ancestry on i interleukin-10 i haplotypes in chronic periodontitis

Abstract

Chronic periodontitis is caused by an inflammatory reaction of the periodontal tissues and alveolar bone. This inflammation is caused by periodontopathic bacteria located in the subgingival biofilm, resulting in inflammatory reactions that may lead to loss of attachment. This tissue destruction is a consequence of host immune and inflammatory responses to specific periodontal pathogens and their metabolic products. Cytokines modulate the immune response, altering its efficiency in the competition against pathogens and increasing periodontal susceptibility. This study investigated genetic polymorphisms in Interleukin 10 (A-1082G, C-819T and C-592A) in 205 individuals from an admixed Brazilian population. A significantly increased risk of developing chronic periodontitis was observed in individuals with low IL-10 production and Amerindian ancestry. These results suggest that the polymorphisms A-1082G, C-819T, and C-592A, which are associated with ancestry, are involved in the susceptibility to the development of chronic periodontitis in an admixed northern Brazilian population.

MiR-21 protected against diabetic cardiomyopathy induced diastolic dysfunction by targeting gelsolin

“…Recently, it was found that miRNAs mediated the benefits of exercise and bariatric surgery to the heart in diabetic/prediabetic patients, and the decreased circulating miR-21 were restored after bariatric surgery or physical activity [25, 29]. Moreover, upregulation of miR-21 or downregulation of its targets could lead to diabetic cardiac dysfunction [30–32]. Therefore, miR-21 might play important roles in diabetic cardiomyopathy, and it may be a new therapeutic target for metabolic diseases such as T2DM and obesity.…”

Interleukin‐10 gene polymorphisms and chronic periodontitis susceptibility: Evidence based on 33 studies

“…Among these studies, 25 studies investigated the ‐1082A>G(rs1800896) polymorphism, 15 studies investigated the ‐819C>T(rs1800871) polymorphism, and 18 studies investigated the ‐592C>A(rs1800872) polymorphism. Nine studies were performed in Asians, 17 in Caucasians, and seven in Latinos. Thirty‐two studies were conducted in systemically healthy subjects and one study in subjects with atherosclerotic and aortic aneurysmal vascular diseases (VD) (VD with CP and VD without CP).…”

“…It has been reported that the ‐1082 G allele and GG genotype are associated with high production of IL‐10. And individuals who are high producers of IL‐10 are most likely protected against CP . In addition, significant lower frequencies of GG and AG genotypes were found among CP cases compared to controls that may be considered protective genotypes against susceptibility to CP.…”

“…In the literature, data on which of the IL‐10 polymorphism contributes to periodontal disease are contradictory. Some of the studies failed to find any evidence of association, and others revealed a possible association between this polymorphism and periodontitis . It is important to note that the associations between the ‐819C>T(rs1800871) and ‐592C>A(rs1800872) polymorphisms and CP risk were suggested by two previous meta‐analyses …”

“…It has been demonstrated that biofilm‐induced inflammation leads to a sequence of innate and modified immune host responses that stimulate the production of cytokines . These cytokines play a pivotal role in destructive processes occurring in periodontitis . Among these cytokines, interleukin‐10 (IL‐10) has been considered as an important contributor to the pathogenesis of periodontal diseases .…”